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Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe
Aging buildings will sooner or later be in need of renovation, which opens opportunities to reduce energy use. Even if economically feasible energy measures or technologies exist, they are not always implemented, leading to an energy efficiency gap. This dissertation deals with how energy measures are handled and why they are enabled or disabled during the planning and design of renovations. Durin
What do we need to know about our students to better provide for more equitable outcomes? Who will succeed depends on many factors, and student personality traits constitute one factor that has received less attention in the engagement and teaching literature. The aim of the present study is to add to discussions on teaching in higher education by exploring how students differ on personality trait
This report aims at providing information on principles that should be considered during planning, establishment and maintenance of work zones, and inspection works. An extensive literature review has been done within the project and some of the results, e.g. of previous CEDR-projects, are included in IRIS. However, not all findings of recent studies are mentioned, as the goal was to keep the repoThis report aims at providing information on principles that should be considered during planning, establishment and maintenance of work zones, and inspection works. An extensive literature review has been done within the project and some of the results, e.g. of previous CEDR-projects, are included in IRIS. However, not all findings of recent studies are mentioned, as the goal was to keep the repo
Limited guidance is available to engineers on how people's walking speed in smoke can and should be represented in the fire safety design process of underground transportation systems, such as road and rail tunnels. To address this issue, the behaviour and movement of people in case of evacuation due to a fire in underground transportation systems has been investigated. In this paper, the relation
PurposeThe purpose of this paper is to explore how witnessing workplace incivility from coworkers and supervisors relates to instigating incivility toward others. A further aim was to investigate if witnessed incivility is indirectly related to instigated incivility via perceived stress and low job satisfaction. An additional aim was to study if control, social support and job embeddedness moderat
Background: In clinical research information can be retrieved through various sources. The aim is to evaluate the agreement between answers in patient questionnaires and clinical reports in a study of patients after radical prostatectomy and patient characteristics associated with agreement between these two data sources. Methods: In the prospective non-randomized longitudinal trial LAParoscopic P
Alzheimer's disease has a long preclinical phase during which amyloid pathology and neurodegeneration accumulate in the brain without producing overt cognitive deficits. It is currently unclear whether these early disease stages are associated with a progressive disruption in the communication between brain regions that subsequently leads to cognitive decline and dementia. In this study we assesse
Background: In an intensive care unit (ICU), privacy and proximity are reported to be important needs of dying patients and their family members. It is assumed that good communication between the ICU team and families about end‐of‐life decisions improves the possibilities of meeting families’ needs, thus guaranteeing a dignified and peaceful death in accordance with end‐of‐life care guidelines. Th
Purpose: The purpose of the study, upon which this paper is based, was to contribute an improved understanding of the vertical extension of buildings, by presenting a development process for its implementation in which the key aspects to consider when planning such extensions are highlighted. Design/methodology/approach: The approach is based on linking the diffusion of innovation together with ca
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associat
While biometric authentication for commercial use so far mainly has been used for local device unlock use cases, there are great opportunities for using it also for central authentication such as for remote login. However, many current biometric sensors like for instance mobile fingerprint sensors have too large false acceptance rate (FAR) not allowing them, for security reasons, to be used in lar
PURPOSE: Survival rates after childhood cancer have increased from 20% to 80% since the 1970s. The increased number of survivors emphasizes the importance of late effects and their monitoring. Late effects may have a strong impact on quality of life in survivors. The purpose of this study was to make key data in a quality registry available for direct clinical use, enabling health care professiona
Objective: To assess and compare the accuracy of imaging methods (ultrasonography (US), computed tomography (CT), angiography, arterially enhanced CT with computed tomographic arterial portography (CTA)), biochemical analyses, and surgical assessment during the operation, in detecting the presence or absence of hepatic metastases in patients with colorectal cancer. Design: Open study. Setting: Uni
