Objective: The incidence of autoimmune diseases, especially inflammatory bowel disease (IBD), has increased substantially. Globally, there are vast differences varying from 0.2/105 in some Asian countries to over 80/105 in the Faroe Islands. Environmental factors have been suggested as triggers. The aim was to investigate the incidence and prevalence of IBD in the 33 municipalities in the county S

CONTEXT: Vitamin D (25OHD) is involved in many physiological functions that decline with age, contributing to frailty and increased risk for negative health outcomes. Whether 25OHD is a long-term risk marker for frailty over a longer time and whether it is consistent with advancing age is unclear. OBJECTIVE: To investigate the association between 25OHD and frailty in older women followed for 10 ye

BACKGROUND: Mental health problems are the main cause of sick leave in today's working age population. Employers are responsible for their employees' work environment and preventing work-related illnesses, but their knowledge regarding mental health problems is lacking. Employer beliefs and support strategies need further exploration. OBJECTIVE: To explore employers' beliefs, knowledge and strateg

While emotional language and imagery in protest esthetics are nothing new, emotions have been repressed in modern political discourse at large, as being seen as irrational if not dangerous. As new media platforms, such as Twitter and Facebook, are becoming central media spaces for live online broadcasting of political protests, they have become an important site of discursive struggle for research

Det er kjent fra før at langdistansebinding av refleksive pronomen forekommeri norsk. Fenomenet har blitt kobla til logoforisitet, men det har også blitt hevdaat langdistanse binding er mulig i visse ikke-logoforiske kontekster. I denne artikkelenargumenterer jeg for at langdistansebinding i norsk alltid er logoforisk,og at det samme gjelder for mellomdistansebinding. Det er bare lokal bindingsom Det er kjent fra før at langdistansebinding av refleksive pronomen forekommer i norsk. Fenomenet har blitt kobla til logoforisitet, men det har også blitt hevda at langdistanse­binding er mulig i visse ikke-logoforiske kontekster. I denne artikkelen argumenterer jeg for at langdistansebinding i norsk alltid er logoforisk, og at det samme gjelder for mellomdistansebinding. Det er bare lokal binding

Cyclin-dependent kinases (CDKs) are activated by cyclins, which play important roles in dictating the actions of CDK/cyclin complexes. Cyclin binding influences the substrate specificity of these complexes in addition to their susceptibility to inhibition or degradation. CDK/cyclin complexes are best known to promote cell cycle progression in the mitotic cell cycle but are also crucial for importa

The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified

Naturally occurring human genetic variants that are predicted to inactivate protein-coding genes provide an in vivo model of human gene inactivation that complements knockout studies in cells and model organisms. Here we report three key findings regarding the assessment of candidate drug targets using human loss-of-function variants. First, even essential genes, in which loss-of-function variants

Aim: The aim of this study was to investigate language ability in internationally adopted children aged 7-8 years with and without a unilateral cleft lip and palate. Methods: We compared 27 internationally adopted children with a unilateral cleft lip and palate, adopted from China, with a group of 29 children without a cleft lip and palate, adopted from different countries. Participants were recru

Ground improvement with lime-cement pillars is becoming increasingly common in the Nordic countries for exploitation of areas with poor stability. However, there is no non-destructive method for quality control of the ground improvement. Significant changes in the electrical properties after mixing of the binders make electrical resistivity tomography (ERT) a potential method. In connection with l

We propose three different estimators that take into account the autocorrelation structure when reconciling forecasts in a temporal hierarchy. Combining forecasts from multiple temporal aggregation levels exploits information differences and mitigates model uncertainty, while reconciliation ensures a unified prediction that supports aligned decisions at different horizons. In previous studies, wei

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibi

BackgroundVasovagal reflex is the most common form of syncope, but the pathophysiological mechanisms that initiate the reflex are not well understood. We aimed to study supine and early orthostatic levels of the neurohormones involved in control of circulatory homeostasis in relation to the onset of tilt‐induced vasovagal syncope (VVS).Methods and ResultsA total of 827 patients who were investigat

Background & Aims: Excess liver iron content is common and is linked to the risk of hepatic and extrahepatic diseases. We aimed to identify genetic variants influencing liver iron content and use genetics to understand its link to other traits and diseases. Methods: First, we performed a genome-wide association study (GWAS) in 8,289 individuals from UK Biobank, whose liver iron level had been

Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in tissue-specific enhancer clusters or super-enhancers. So far, such domains have been defined through clustering of enhancers in linear genome maps rather than in three-dimensional (3D) space. Furthermore, their target genes are often unknown.