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Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with type 2 diabetes (T2D) and 24,440 non-diabetic control participants from 5 ancestries. We identify gene-level associations of rare variants (with minor allele frequencies of less than 0.5%) in 4 genes at exome-wide si
Understanding catchment behaviour through rainfall-runoff models allows decision makers for proper planning and operation in context of flood risk management. However accurate rainfall-runoff and flood modelling at high spatio-temporal resolutions still remains a significant challenge in any hydrologic and hydraulic studies. This study seeks to develop Hydrologic Engineering Centre’s Hydrologic Mo
Objective: To validate a 7-day estimated dietary record routine with standardized portion sizes and household measuring in a clinical setting with the doubly labelled water (DLW) method as the reference method. Design: Energy expenditure was measured with deuterium (2H) and oxygen-18 (18O), and water loss was estimated by 2H dilution as part of the DLW measurements. Energy and water intake was mea
Hymns to Unknown Heroines part III – Elna, 2015 Slide and sound installationHymns to Unknown Heroines, part III is the latest iteration of a multifaceted work. The starting point was an anonymous photographic archive from the 1920s that depicts a Scottish family over several years. Many of the photographs portray women engaged in recreational activities, portraying an undemanding lifestyle that ca
The paper analyses dwell time delays for commuter trains in Stockholm and Tokyo. In both cities, small dwell time delays of at most five minutes make up around 90% of the total delays. Therefore, it is valuable to understand and deal with these disturbances. To this end, we use high resolution data on dwell times and passenger counts from both countries over the last several years. We find that thThe paper analyses dwell time delays for commuter trains in Stockholm andTokyo. In both cities, small dwell time delays of at most five minutes makeup around 90% of the total delays. Therefore, it is valuable to understandand deal with these disturbances. To this end, we use high resolution data ondwell times and passenger counts from both countries over the last severalyears. We find that these d
Action-based payments that compensate farmers for adopting land-management measures to preserve and en- hance the environment have been criticized for being ineffective. The root of the problem is that farmers are not paid for achieving a desired environmental benefit, but compensated for their costs of management. There is growing interest in formulating result-based economic incentives. By payin
The aim of the Massive Open Online Course (MOOC) ‘Work and Technology on Human Terms’ was to be a modern, highly accessible study material in Ergonomics/Work science to contribute to safer and healthier workplaces. The course targets engineering students, but also students in economics, human relations, physiotherapy, occupational health, as well as professionals. The purpose of this paper is to d
Bullshit-sensitivity is the ability to distinguish pseudo-profound bullshit sentences (e.g. “Your movement transforms universal observations”) from genuinely profound sentences (e.g. “The person who never made a mistake never tried something new”). Although bullshit-sensitivity has been linked to other individual difference measures, it has not yet been shown to predict any actual behavior. We the
We present the first reconstruction of the micrometeorite flux to Earth in the Silurian Period. We searched 321 kg of condensed, marine limestone from the Late Silurian Cellon section, southern Austria, for refractory chrome-spinel grains from micrometeorites that fell on the ancient sea floor. A total of 155 extraterrestrial spinel grains (10 grains >63 μm, and 145 in the 32-63 μm fraction) were
It is often unavoidable to combine data from different sequencing centers or sequencing platforms when compiling datasets with a large number of individuals. However, the different data are likely to contain specific systematic errors that will appear as SNPs. Here, we devise a method to detect systematic errors in combined datasetIs. To measure quality differences between individual genomes, we s
Although border politics have been given much theoretical attention in recent years, empirical studies of identity construction among border police officers are less common. In 2014, a two-year collaborative project partly funded by the EU was initiated in order to increase international collaboration between border police officers in the Baltic Sea area. The participating organizations were borde
Background: Branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) presents a clinical conundrum. Rigorous long-term surveillance or surgical resection is recommended. The economic consequences of the management have not been fully investigated. Methods: A Markov decision model compared 4 strategies for low-risk BD-IPMN: I = upfront total pancreatectomy, II = upfront partial pancreatectomy,
High body mass index (BMI) is associated with development of hematological malignancies (HMs). However, although BMI is a well-established measurement of excess weight, it does not fully reflect body composition and can sometimes misclassify individuals. This study aimed at investigating what body composition measurements had highest association with development of HM. Body composition measurement
A land use policy shift is taking place in a growing number of cities regarding parking, whereby a conventional supplymanagement approach is being replaced with a parking management approach. As part of this policy shift, manycities are lowering their parking requirements. This study analysed changes in car use, car ownership, spatial parkingpatterns and the consequences for the everyday life of r
