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The second most common neurodegenerative disease, Parkinson’s disease, is linked with an amyloid forming protein, alpha-synuclein. Hallmarks of Parkinson’s disease are progressive loss of dopaminergic neurons and accumulation of intraneuronal inclusions termed Lewy bodies. Major components of Lewy bodies are amyloid fibrils formed by alpha-synuclein and various lipids and cell organelles. In this
The first book in this exciting new series, written and edited by a group of international experts in the field, this exciting new volume covers the latest advances and challenges in the next generation of antennas. Antenna design and wireless communication has recently witnessed their fastest growth period ever in history, and these trends are likely to continue for the foreseeable future. Due to
The most recent and promising therapeutic strategies for inflammatory bowel disease (IBD) have engaged biologics targeting single effector components involved in major steps of the immune-inflammatory processes, such as tumor necrosis factor, interleukins or integrins. Nevertheless, these molecules have not yet met expectations regarding efficacy and safety, resulting in a significant percentage o
Approaches integrating interdisciplinary perspectives are necessary to address current and future health and environmental challenges. Many policy initiatives have embraced more holistic approaches to tackle these challenges, e.g., the One Health concept, the Farm to Fork (F2F), Biodiversity and Chemical strategies within the European Green Deal and the global Sustainable Development Goals (SDGs).
Understanding and quantifying the global methane (CH4) budget is important for assessing realistic pathways to mitigate climate change. CH4 is the second most important human-influenced greenhouse gas in terms of climate forcing after carbon dioxide (CO2), and both emissions and atmospheric concentrations of CH4 have continued to increase since 2007 after a temporary pause. The relative importance
Nominal classification systems provide a unique window into the intersection of grammar, semantics, and cognition. Found in more than half of the world's languages, these systems possess both universal and language-specific properties. Nominal classification systems of a specific type, featuring classifiers marked in multiple morphosyntactic loci, are found in many languages in Northwestern Amazon
Top predators can affect the behaviour of prey species via lethal (direct kill) or non-lethal effects (i.e., through predation risk). For example, prey species may move from areas perceived as risky to safer spaces where predation risk is lower, which can have important consequences for investment in foraging, movement, and mating, and for the behaviour and habitat use of other species, such as me
Though child anthropometric failure (CAF) is a persistent problem in India, previous studies have often neglected state-level variance and aggregated moderate and severe CAF categories. This study addresses this gap by examining moderate and severe malnutrition across India's states and union territories (UTs) from 1993 to 2021. Data of children under 2 years old from five waves of National Family
Background: Acute postoperative pain is a common problem in clinical practice and merits attention considering its potential long-term adverse effects. This systematic review covers current knowledge on methods for individual prediction of postoperative pain. Methods: A systematic literature search was conducted using the PubMed, EMBASE, and CINAHL databases for original studies with adult patient
