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Streaming instability of multiple particle species in protoplanetary disks

The radial drift and diffusion of dust particles in protoplanetary disks affect both the opacity and temperature of such disks, as well as the location and timing of planetesimal formation. In this paper, we present results of numerical simulations of particle-gas dynamics in protoplanetary disks that include dust grains with various size distributions. We have considered three scenarios in terms

The hidden Niemann-Pick type C patient : clinical niches for a rare inherited metabolic disease

Background: Niemann-Pick disease type C (NP-C) is a rare, inherited neurodegenerative disease of impaired intracellular lipid trafficking. Clinical symptoms are highly heterogeneous, including neurological, visceral, or psychiatric manifestations. The incidence of NP-C is under-estimated due to under-recognition or misdiagnosis across a wide range of medical fields. New screening and diagnostic me

Innovative assistive technologies in dementia care between hopes and disillusion. A critical reflection based on the Tech@home experience in Sweden

Global dementia rates will more than triple by 2050, thus challengingsociety. Due to ageing in place policies, informal caregiving is increasing asmore people with dementia continue living at home despite significant careneeds. While most caregivers are willing to act as such, they are notalways adequately supported, thus reporting a high burden, worse mentaland physical health. Innovative Assisti

Adaptive Water Management : On the Need for Using the Post-WWII Science in Water Governance

Although the UN concluded, already in 1997, that water would be the most contentious issue of the 21st century, water governance is still confused, nearly everywhere. Even the severe impacts of escalating water bankruptcy and global warming have so far failed to incur a marked improvement in governance systems. The global community has adopted sustainable development as a common vision and guide f

Timing rather than movement decisions explains age-related differences in wind support for a migratory bird

Migratory birds must make complex decisions to use wind to their advantage during flight and increasing flight performance is particularly important while crossing ecological barriers. Age-related differences in how birds deal with wind have suggested experience improves necessary skills in gaining positive wind support. However, differences in wind support between age groups over ecological barri

Encounters involving planetary systems in birth environments : The significant role of binaries

Most stars form in a clustered environment. Both single and binary stars will sometimes encounter planetary systems in such crowded environments. Encounter rates for binaries may be larger than for single stars, even for binary fractions as low as 10-20 per cent. In this work, we investigate scatterings between a Sun-Jupiter pair and both binary and single stars as in young clusters.We first perfo

Autosomal recessive Stickler syndrome associated with homozygous mutations in the COL9A2 gene

Background: Stickler syndrome is a hereditary disorder of collagen tissues causing ocular, auditory, orofacial, and joint manifestations. Ocular findings typically include vitreous degeneration, high myopia, retinal detachment, and cataract. Many subjects demonstrate sensorineural or conductive hearing loss. The inheritance is autosomal dominant with mutations in COL2A1, COL11A1, or COL11A2 or aut

Identifying and modelling clinical subpopulations from the Malmö breast tomosynthesis screening trial

Virtual Clinical Trials (VCT) are an effective tool to evaluate the performance of novel imaging systems using computer simulations. VCT results depend on the selection of virtual patient populations. In the case of breast imaging, virtual patients should be matched to a desired clinical population in terms of selected anatomical or demographic descriptors. We are developing a virtual population o

Is increased size at birth associated with longevity on the population level? – A historical and comparative analysis of regions in Sweden

Increased population longevity could be influenced by early life factors. Some areas have long-lived populations, also in a historical perspective. We aimed to study these factors in Halland, an area with the highest life expectancy in Sweden. We collected archival data on gestational age and birth characteristics from 995 live singleton full-term births at the Halmstad Hospital, Halland, from the

Analyzing the Stressors for Frontline Soldiers Fighting Against Coronavirus Disease 2019 Pandemic

This study aimed to analyze stressors to which medical staff is vulnerable due to the coronavirus disease 2019 (COVID-19) pandemic. It also imposes a hierarchy on complex relations among stressors for excavating underlying structure and builds a model of interrelationships contrasting reality. The design of this study comprises a literature survey, data collection from primary sources, and analysi

How the formation of Neptune shapes the Kuiper belt

Hydrodynamical simulations predict the inward migration of giant planets during the gas phase of the protoplanetary disc. This phenomenon is also invoked to explain resonant and near-resonant exoplanetary system structures. The early inward migration may also have affected our Solar System and sculpted its different minor planet reservoirs. In this study we explore how the early inward migration o

The bacterial amyloids phenol soluble modulins from staphylococcus aureus catalyze alpha-synuclein aggregation

Aggregated α-synuclein (α-syn) is the main constituent of Lewy bodies, which are a pathological hallmark of Parkinson’s disease (PD). Environmental factors are thought to be potential triggers capable of initiating the aggregation of the otherwise monomeric α-syn. Braak’s seminal work redirected attention to the intestine and recent reports of dysbiosis have highlighted the potential causative rol