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BACKGROUND: Mesenteric panniculitis (MP) is a rare condition that historically has been associated with the presence of malignancy. Paraneoplastic phenomena in general regress with cure and in most cases with treatment of the cancer. This study was undertaken to determine whether MP regressed with cancer treatment and cure.METHODS: This was a retrospective review of a database of all patients with
BACKGROUND: The balance between stabilizing and destabilizing atherosclerotic plaque components is used in experimental studies and in imaging studies to identify rupture prone plaques. However, we lack the evidence that this balance predicts future cardiovascular events. Here we explore whether a calculated histological ratio, referred to as vulnerability index (VI), can predict patients at highe
Background To understand when results from observational studies and randomized trials are comparable, we performed an observational emulation of a target trial designed to ask similar questions as the VALIDATE (Bivalirudin Versus Heparin in ST-Segment and Non-ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy) randomized trial. The VALIDATE trial compared the ef
AIMS: There are few cohorts of type 1 diabetes that follow individuals over more than half a century in terms of health outcomes. The aim of this study was to examine associations between type 1 diabetes, diagnosed before age 18, and long-term morbidity and mortality, and to investigate whether cognitive ability plays a role in long-term morbidity and mortality risk.METHODS: In a Swedish cohort, 1
Type 1 conventional dendritic cells (cDC1s) are rare immune cells critical for the induction of antigen-specific cytotoxic CD8+ T cells, although the genetic program driving human cDC1 specification remains largely unexplored. We previously identified PU.1, IRF8, and BATF3 transcription factors as sufficient to induce cDC1 fate in mouse fibroblasts, but reprogramming of human somatic cells was lim
Introduction: Understanding normal skeletal uptake of 18F-sodium fluoride (18F-NaF) in positron emission tomography/computed tomography (PET/CT) is important for clinical interpretation. Quantification of tracer uptake in PET/CT is often performed by placing a volume of interest (VOI) to measure standard uptake values (SUVs). Manual placement of this VOI requires a subjective decision and can only
The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+
PAM50 intrinsic subtyping and risk of recurrence (ROR) score are approved for risk profiling in postmenopausal women. We aimed to examine their long-term prognostic value in terms of breast cancer-free interval (BCFi) and overall survival (OS) (n = 437) in premenopausal women randomised to 2 years of tamoxifen versus no systemic treatment irrespective of hormone-receptor status. Intrinsic subtypin
We show how the interplay between feedback and mass-growth histories introduces scatter in the relationship between stellar and neutral gas properties of field faint dwarf galaxies (M∗ 106, M⊙). Across a suite of cosmological, high-resolution zoomed simulations, we find that dwarf galaxies of stellar masses 105 ≤ M∗ ≤ 106, M⊙ are bimodal in their cold gas content, being either H i-rich or H i-defi
Human papillomavirus type 16 (HPV16) E1 and E6 proteins are produced from mRNAs with retained introns, but it has been unclear how these mRNAs are generated. Here, we report that hnRNP D act as a splicing inhibitor of HPV16 E1/E2- and E6/E7-mRNAs thereby generating intron-containing E1- and E6-mRNAs, respectively. N- and C-termini of hnRNP D contributed to HPV16 mRNA splicing control differently.
With cyber-physical systems opening to the outside world, security can no longer be considered a secondary issue. One of the key aspects in security of cyber-phyiscal systems is to deal with intrusions. In this paper, we highlight the several unique properties of control applications in cyber-physical systems. Using these unique properties, we propose a systematic intrusion-damage assessment and m
Tumor associated macrophages (TAMs) are key cells in creating an immunosuppressive tumor microenvironment (TME). In general, presence of TAMs is associated with worse outcome in cancer patients. Macrophages with anti-tumor effect can be found in the TME but are usually in minority. This thesis focuses on the role of innate immune cells, and especially macrophages, in breast cancer. In the first pr
We have combined high-energy surface X-ray diffraction (HESXRD) with 2D surface optical reflectance (2D-SOR) to perform in situ electrochemical measurements of a Au(111) electrode in 0.1 M HClO4 electrolyte. We show that electrochemically induced changes to Au(111) surface during cyclic voltammetry can be simultaneously observed with 2D-SOR and HESXRD. We discuss how small one atom high 1x1 island
The bone morphogenetic protein (BMP) and Notch signaling pathways are crucial for cellular differentiation. In many cases, the two pathways act similarly; for example, to inhibit myogenic differentiation. It is not known whether this inhibition is caused by distinct mechanisms or by an interplay between Notch and BMP signaling. Here we demonstrate that functional Notch signaling is required for BM
Human papillomavirus type 16 (HPV16) is the most common high-risk type and isassociated with more than 50% cervical cancer cases as well as a number of headand neck cancer cases. The life cycle of HPV16 is strictly linked to celldifferentiation in the squamous epithelium with expression of the HPV16 earlygenes. The oncoproteins E6 and E7 are essential for preventing apoptosis andinducing prolifera
BACKGROUND: Cytomegalovirus (CMV) specific T-cells are known to provide long-term control of CMV reactivation, which is a frequent complication of hematopoietic stem cell transplantation. We have studied 58 pediatric patients after hematopoietic stem cell transplantation who suffered from CMV reactivation to reveal which functional T cell subset is best correlating with successful reactivation res
