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Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype(s) responsible for its erectogenic effect is not known. Here we report that the dopamine D-4 receptor plays a role in the regulation of penile function. ABT-724 is a selective dopamine D4 receptor agonist that ac
Vitamin D deficiency is associated with susceptibility to tuberculosis, and its biologically active metabolite, 1 alpha,25 dihydroxyvitamin D-3 (1 alpha,25(OH)(2)D-3), has pleiotropic immune effects. The mechanisms by which 1 alpha,25(OH)(2)D-3 protects against tuberculosis are incompletely understood. 1 alpha,25(OH)(2)D-3 reduced the growth of mycobacteria in infected human PBMC cultures in a dos
When Harry Sawyerr wrote his essay "What is African Theology?", published first in African Theological Journal, vol. 4 (1971), it appeared from its contents that he was making short comments about James Cone's Black theology that could have disappeared in the midst of more pressing African theological issues. Sawyerr's article was not primarily intended as a critique of Cone's Black theology; inst
The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. In the third study the expression of the integrins alpha10beta1 and alpha11beta1 on MSCs was characterized and the involvement of these two integrins in cartilage development was investigated in vit
In type I diabetes mellitus (T1DM), the frequency of antibodies against insulin (IAA), glutamic acid decarboxylase-65 (GAD65), ICA512/IA2 (IA2), and islet cell antigens (ICA) vary with human leukocyte antigen (HLA) composition of the patient. IAA, IA2 autoantibodies, and ICA are increased in DQ8 positives; GAD65 antibodies are increased in DQ2 positives. MHC class I chain-related gene-A (MICA) is
Popular Abstract in Swedish Många tolkningar och användningsområden har av olika forskare föreslagits för det gammaltestamentliga offret shelamin. Detta offer hade också en oklar plats i den israelitiska kulturen. Avsaknaden av konsensus och misslyckandet med att nå fram till en tillfredsställande lösning på gåtan gör shelamim till ett intressant offer att undersöka med hjälp av modern ritualforskFor the sacrifice shelamim in the Hebrew Bible, scholars have suggested a number of different interpretations and uses. This sacrifice also had an ambiguous role in Israelite culture. Lack of a general consensus and the failure to reach a satisfying solution makes the shelamim a puzzle and an interesting sacrifice to investigate with insights gained from modern ritual studies. In this study, it i
The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound hea
Popular Abstract in Swedish Sophia Elisabeth Brenner (1659-1730) var Sveriges första stora kvinnliga poet. Hon var verksam som författare och lärd kvinna under femtio år, och var dessutom en flitig brevskrivare. Avhandlingen baseras på en inventering av bevarade brev till och från Sophia Brenner skrivna på latin, svenska, franska och italienska. Hennes nylatinska korrespondens med danske Otto SpeSophia Elisabeth Brenner (1659-1730) was Sweden's first great female poet, writing and publishing her poems over a period of fifty years. She was also, however, a prolific letter writer. The dissertation is based on an inventory of all the preserved letters to and from her written in Latin, Swedish, French and Italian. Her Neo-Latin correspondence with the Dane Otto Sperling the Younger is presen
Dendritic cells (DC) are the most potent APC in the organism. Immature dendritic cells (iDC) reside in the tissue where they capture pathogens whereas mature dendritic cells (mDC) are able to activate T cells in the lymph node. This dramatic functional change is mediated by an important genetic reprogramming. Glycosylation is the most common form of posttranslational modification of proteins and h
Popular Abstract in Swedish Sammanfattning I debatter och forskning om narkotikapolitik anges den svenska och nederländska modellen ofta som ett motsatspar. Såväl målet för, som utformningen av, narkotikapolitiken har framställts som radikalt olika. Detta synsätt kan sägas vara riktigt. Målet för den svenska narkotikapolitiken är att skapa ett narkotikafritt samhälle. Den nederländska strävar efteIn debates about the Swedish and Dutch drug policies are usually positioned as opposites. The goal for the Swedish drug policy is to create a 'drug-free society'; while in the Netherlands a harm reduction approach prevails. In this study a drug policy is considered a practice of formal social control that can develop differently depending on the contexts in which it emerged. The period studied sta
Integrated development environments (IDEs) increase programmer productivity, providing rapid, interactive feedback based on the syntax and semantics of a language. A heavy burden lies on developers of new languages to provide adequate IDE support. Code generation techniques provide a viable, efficient approach to semi-automatically produce IDE plugins. Key components for the realization of plugins
This chapter provides a physical background to the following ones. It describes the particle and wave properties of light and the diffraction, polarization, refraction, reflection, and absorption of light and statistics of photon emission and absorption. Planck’s law of heat radiation is described in various mathematical and graphical ways. One section is devoted to a simplified description of the
The Internet is a huge world-wide packet switching network comprised of more than 13,000 distinct subnetworks, referred to as Autonomous Systems (ASs) . They all rely on the Internet Protocol (IP) for transport of packets across the network. And most of them use shortest path routing protocols , such as OSPF or IS-IS, to control the routing of IP packets within an AS. The idea of the routing is ex
Background Although physiology-based assessment of coronary artery stenosis using instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) are established methods of guiding coronary revascularization, its clinical outcome in long-term deferral needs further evaluation, especially with acute coronary syndrome as a clinical presentation. The aim was to evaluate the long-term clinical o
In some nuclear power plants, the containment liners are embedded in concrete. The purpose of the containment liner is to minimize the risk of radioactive leakage by granting a leak-tight containment building. In the presence of flaws in the surrounding concrete, such as voids, or foreign objects embedded in the concrete, there is a risk that the liner plate might corrode. This could degrade the l
Background: Out of Hospital Cardiac arrest (OHCA) survivors with ST elevation (STE) with or without shockable rhythms often benefit from coronary angiography (CAG) and, if indicated, percutaneous coronary intervention (PCI). However, the benefits of CAG and PCI in OHCA survivors with nonshockable rhythms (PEA/asystole) and no STE are debated. Methods: Using the International Cardiac Arrest Registr
