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OBJECTIVE: Children who undergo surgery for complex congenital cardiac disease are reported to be at increased thrombotic risk. Our aim was to evaluate long-term changes in the haemostatic system after surgery, to compare markers of activated coagulation in children having surgery with those in a healthy control population, and to relate them to adverse clinical outcome.Patients and methodsWe stud

The n-CoDeR recombinant antibody gene libraries are built on a single master framework, into which diverse in vivo-formed complementarity determining regions (CDRs) are allowed to recombine. These CDRs are sampled from in vivo-processed and proof-read gene sequences, thus ensuring an optimal level of correctly folded and functional molecules. By the modularized assembly process, up to six CDRs can

Articulatory data were collected for the Swedish vowels /iː, yˌ, ʉ̟ː/ from nine speakers each of Stockholm, Gothenburg, and Malmöhus Swedish, and the tongue positions and their dynamics analysed using Functional Data Analysis (FDA). Results showed that the general tongue positions for /iː/ and /yː/ are similar and clearly different from /ʉ̟ː/ in all three dialects. Variation within the Stockholm a

My diploma project is a design proposal for a Rudolf Steiner School in Sirende, a village 12 km outside Kitale Town, Kenya. On Initiative taken by the anthroposophical association Föreningen Sofia in Sweden, a Steiner school opened in Sirende in year 2008. Today the school is in a very bad condition with over crowded classrooms and poor sanitary conditions. The need for a new school building is ur

Purpose: The purpose is to examine how IKEA works with customer brand co-creation and how it can be further leveraged in the digital era. Methodology: This paper adopts a qualitative case study method, where the primary data consists of an interview with a Social Media Specialist with pre-existing knowledge of brand co-creation at IKEA in Sweden. Furthermore, research about IKEA and the ways they

Climate change affects us all through rising sea levels, environmental degradation and rising temperatures. The issue with climate change emerges from the fact that the discharge of carbon dioxide creates negative externalities, which causes the market to reach an inefficient allocation. The European Union has chosen to respond to the problem with a market-based policy and established an emissions

The growing interest and practice in outer space activities is the cause of a developing and more various space industry. The implication of an increasing human presence in outer space, as a result of such a development, is questioned in this study through an analysis of extraterrestrial mining. Three leading actors’ business-plans in the industry of extraterrestrial mining are examined, with the

The complement system is fundamental to both innate and adaptive immunity and can be initiated via the classical, lectin or alternative pathways. Cleavage of C4 by MASP-2, the initiating protease of the lectin pathway, is a crucial event in the activation of this pathway, preceding the eventual formation of the C3 convertase (C4bC2a) complex on the pathogen surface. Interactions required for the c

Here, monoolein-based nanoparticles (NPs), obtained through fragmentation of bulk liquid crystalline phases, and stabilized by two different emulsifiers, namely, Pluronic F127 (PF127) and lauroylcholine chloride (LCh), are investigated for structural features and for short-term in vitro cytotoxicity. Depending on the emulsifiers, different morphologies of the lipid NPs (cubosomes and liposomes) ar

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the peripheral joints that eventually leads to cartilage destruction and bone erosion. The causes of RA remain largely unknown, but considerable evidence suggests a multifactorial aetiology involving both environmental and genetic factors. Large efforts have been directed towards the understanding of the mo

This dissertation discusses aspects of the syntax of Övdalian, a variety spoken by ca. 2,500 people in the province of Dalecarlia in Sweden. Initially, an overview of the history and current status of the language of Älvdalen is given, and the focus of the dissertation is on certain syntactic phenomena that have been well studied from a comparative and diachronic perspective in other Scandinavian

This study investigated the effect of experimental task on the processing of Central Swedish word accents. Both reaction times and response times were included as behavioural measures in a word accent/suffix (mis-)match paradigm. Results support the hypothesis that Accent 2 is associated with a heavier lexical functional load as compared to Accent 1. This effect was found to be relatively task-ind

Moisture is decisive for a large number of reaction, binding and transport processes in concrete affecting the durability, shrinkage and performance in various environments. Consequently, the role of moisture must be assessed and quantified in a diagnosis of concrete degradation by moisture measurements and a survey of environmental actions. The paper gives an over-view of the role of moisture in

Knowledge-management has a long history in the work place enacted variously as apprenticeship, corporate libraries, and professional training programs. As an academic topic, it first appeared after Nonaka's (1991) paper. Western authors on knowledge-management generally treat "knowledge" and "information" as some kind of a commodity. "Knowledge" and "information" are thought to be acquired and tra

This thesis, which is based on four original papers, deals with human dendritic cells (DCs) in immunity and allergy. DCs play a key role in the regulation of immune responses by acting as the sentinels of the immune system, specialized in the uptake of a diverse range of antigens. These cells migrate to local lymph nodes and become highly efficient in inducing T cell proliferation, thus inducing a