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To date, there have been several detections of high-mass black hole binaries in both the Milky Way and other galaxies. For some of these, the spin parameter of the black hole has been estimated. As many of these systems are quite tight, a suggested origin of the spin is angular momentum imparted by the synchronous rotation of the black hole progenitor with its binary companion. Using Cygnus X-1, t
The toll-like receptors, TLR5 and TLR7, have recently been proposed in asthma immunopathogenesis. While supporting data come from animal or in vitro studies, little is known about TLR5 and TLR7 expression in human asthmatic airways.
Abstract in Spanish En el presente trabajo buscamos poner en cuestión la relación entre desarrollo, desigualdad y territorio en el contexto actual de la globalización y en el marco de las políticas públicas dirigidas, supuestamente, a favorecer a los actores sociales de menores recursos. Para ello nos centramos en un estudio de caso en el nordeste de la provincia de Misiones, Argentina. Aquí la ac
Popular Abstract in Swedish När vi drabbas av infektioner är det immunförsvaret som ser till att de invaderande organismerna oskadliggörs. För att immunförvaret skall veta vilka organismer och celler som skall attackeras måste det kunna skilja på kroppseget och främmande. En del främmande organismer lever antingen i symbios med den egna kroppen eller så utgör de inget hot. Teoretiskt sett är mat kThe immune response is designed to protect the body from harmful microbial invasions. However, when the immune system attacks itself instead, an autoimmune reaction starts that damage our own cells, tissues and organs. Despite decades of research concerning the etiology of autoimmune diseases the molecular mechanisms of these disorders are poorly understood as they are complex and influenced by bo
Popular Abstract in Swedish Immunförsvaret är till för att bekämpa patogener såsom bakterier, virus, parasiter och svamp. Det kan också bekämpa cancerceller även om dessa har en förmåga att undkomma till slut. För att kunna känna igen och eliminera främmande kroppar måste immunförsvaret kunna skilja på dem och våra kroppsegna ämnen. Immunförsvaret består av vita blodkroppar. Vita blodkroppar är enT cells constitute a heterogenous population of lymphocytes. Their unifying property is that they express surface bound antigen-receptors, called T cell receptors (TCRs). The TCR is a heterodimer composed of either TCRalpha and beta chain proteins (alphabeta TCR) or gamma and delta chain proteins (gammadelta TCR). Depending on which TCR isotype that is expressed, the T cells are divided into alpha
Popular Abstract in Swedish Människans immunsystem utgörs av en komplex sammansättning av celler och molekyler, som interagerar med varandra men även med kroppens övriga vävnader. Dess huvudsakliga uppgift är att förse sin värd med ett försvar mot yttre och inre förhållanden, som kan orsaka denna skada, t.ex. bakterie- och virusinfektioner eller betingelser för utveckling av cancer. Denna försvarsThis thesis is based upon four original papers in which human dendritic cells (DCs) and B cells have been analyzed in terms of how they influence the character of adaptive immune responses. DCs isolated from human tonsils were found to possess a capacity to directly regulate proliferation, isotype switching, and antibody production in B cells. DC-produced cytokines, including IL-13, were identifie
Antimicrobial peptides produced by epithelial cells and neutrophils represent essential elements of innate immunity, and include the defensin and cathelicidin family of antimicrobial polypeptides. The human cathelicidin cationic antimicrobial protein-18 is an antimicrobial peptide precursor predominantly expressed in neutrophils, and its active peptide LL-37 is released from the precursor through
Objective: To assess mortality in patients with rheumatoid arthritis ( RA) treated with tumour necrosis factor (TNF) inhibitors, compared with a standard RA population. Methods: Patients were recruited from a regional register, which includes over 90% of patients with RA treated with TNF blockers in the area in 1999 or later, and a local community-based cohort of patients with RA, established in 1
Background & objectives: Human and animal cystatins have been shown to inhibit the replication of certain viruses and bacteria, though it is not directly demonstrated that the effects are due to protease inhibitory capacity of the cystatins. We report antibacterial properties of a novel antimicrobial peptidyl derivative, (2S)-2-(N-alpha-benzyloxycarbonyl-arginyl-leucylamido)-1-(E)-cinnamoyla m
Mouse models of asthma are now being used extensively in drug research. However, the successful unravelling of combinatorial interplays of cells and molecules in the murine airways may not be matched by equally successful demonstrations of an asthma-like pathophysiology. Here, Carl Persson, Jonas Erjefalt, Magnus Korsgren and Frank Sundler discuss the fact that major features of asthma may still n
Complement analysis in the clinic is usually associated with the quantification of C3 and C4, measurement of C1-inhibitor and screening for complement activity. These analyses have been available in routine diagnostic laboratories for decades. In recent years, however, the field of complement analysis has expanded considerably, with the introduction of novel assays to detect complement activation
The structure, formation, and evolution of the Milky Way bulge is a matter of debate. Important diagnostics for discriminating between models of bulge formation and evolution include alpha-abundance trends with metallicity, and spatial abundance and metallicity gradients. Due to the severe optical extinction in the inner Bulge region, only a few detailed investigations of this region have been per
Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many health benefits have been ascribed to Allium extracts, including hypotensive and vasorelaxant activities. However, the molecular mechanisms underlying these effects remain unknown. Intriguingly, allicin and DADS shar
The CC chemokine CCL25 (TECK) is selectively expressed in the thymus and small intestine, indicating a potential role in T lymphocyte development. In the present study we examined the role of CCL25 in the generation of the small-intestinal CD8alpha alpha(+)CD3(+) intraepithelial lymphocyte (IEL) compartment. CCL25 mRNA expression in the murine small intestine increased at three weeks of age and co
