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The co-occurrence of α-synuclein (αSyn) and Tau in synucleinopathies and tauopathies suggests a complex interplay between these proteins. Their cross-seeding enhances fibrillization, leading to the formation of diverse amyloid-specific structures enriched with β-sheets, which may influence their biological functions. However, existing tools cannot differentiate structural polymorphs directly in ce

Separating how surface and subsurface species affect catalytic function is a challenging task in heterogeneous catalysis, particularly when deposition and segregation take place at reaction conditions. Here, we report on an operando approach to establish surface/subsurface/function correlations. Using temperature modulations we oscillate carbon deposition and segregation over a Pd catalyst. Cataly

Objective: The aim of this study is to describe how the use of diagnostic imagingfor prostate cancer (PCa) has evolved over time and to determine whether thereare any differences in access to diagnostic imaging, type of cancers detected, andmortality based on the education level of patients.Methods: 11,063 men were recruited between 1991 and 1996 and thenprospectively followed until 2020. All new

Uppsatsen syftar till att söka förståelse till varför tvister mellan fackförbund om vem som ska teckna kollektivavtal uppstår. Arbetsmarknadernas parter är i allmänhet ense om att det som regel bör finnas ett kollektivavtal på varje avtalsområde. Kollektivavtalets speciella rättsverkningar gör det viktigt för fackförbunden att vara avtalspart i ett kollektivavtal. Kollektivavtalet sätter i stor utThe aim of this essay is to seek understanding about why conflicts appear between trade unions regarding which one of them should sign the collective agreement in the workplace. The labour market parties are in general in an agreement that there should only be one applicable collective agreement in every area of work. The unique effects of the collective agreement make it crucial for the trade uni

This thesis deals with the enforcement of intellectual property rights as an abuse of dominance. In particular after refusal to license a patent, which is essential for a standardized technology. Seeking for injunction relief may in some circumstances violate applicable competition law. The analysis will provide a hint, whereas patent holder who is dominating in particular market can or should be

This qualitative study examines how the Israeli occupation affects and interferes with Palestinian intimate relationships in the Occupied Palestinian Territories. The research material consists of semi-structured interviews with female students and graduates conducted during a short period of fieldwork in the West Bank in September 2016. The thesis shows that Israeli mechanisms of control, such as

This thesis examines how learning is depicted in policy documents for public libraries on municipal and national level in Sweden. The documents analyzed are library plans from five Swedish cities, as well as the proposal for a national strategy presented in 2019 by the National Library of Sweden. The method used is Carol Bacchi’s What’s the problem represented to be-approach. Pierre Bourdieu’s the

Quantitative evaluations are valuable in the strive for improvements and asserting quality. However, the field of Command & Control (C2) evaluations are hard to navigate, and it is difficult to find the correct measurement for a specific situation. A comprehensive Scoping Study was made concerning measurements of C2 performance and effectiveness. A lack of an existing appropriate framework for

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of the heritability of this disease. Here, to test the hypothesis that

Analys av hjältinnan utifrån ett feministiskt perspektiv. En jämförelse mellan Jane Austens hjältinna Elizabeth Bennet i Pride and Prejudice och Suzanne Collins hjältinna Katniss Everdeen i The Hunger Games.Analysis of the heroine from a feminist perspective. A comparison between Jane Austen's heroine Eliabeth Bennet in Pride and Prejudice and Suzanne Collins' heroine Katniss Everdeen in The Hunger Games.

Two Burmese eclipse calculations, one lunar and one solar, are analysed using examples from a Burmese manuscript. The fundamental parameters are with some important exceptions the same as in the Suryasiddhanta, but the handling of, for instance, parallax in the solar eclipse is different and much simplified. Specific to Burma are also the shadow calculations.

The fact that breast cancer patients with local or distal dissemination exhibit decreased survival, promotes a search for novel mechanisms to suppress such tumor progression. Here we have determined the expression of pro-inflammatory cysteinyl leukotriene receptors (CysLTRs) in breast tumor tissue and their signaling effect on breast cancer cell functions related to tumor progression. Patients wit

Abstract in Undetermined[Context and motivation] There is considerable flexibility in requirements specifications (both functional and non-functional), as well as in the features of available OSS components. This allows a collaborative matching and negotiation process between stakeholders such as: customers, software contractors and OSS communities, regarding desired requirements versus available

Intracellular deposits of neurofibrillary tau tangles and extracellular Aβ plaques are closely associated with Alzheimer’s disease. The mapping of thermodynamic parameters, including solubility limits, indicates when a protein forms amyloid fibrils or remains in solution. This reveals the direction of change of the system and may help in understanding drift and steady states in living systems. Her

Action-detected two-dimensional electronic spectroscopy (A-2DES) provides valuable insights into ultrafast dynamics within functional materials and devices by measuring incoherent signals like photocurrent. This work details the implementation and optimization of a pulse-shaper-based A-2DES setup, focusing on methodological strategies crucial for acquiring high-fidelity data. We present a comprehe