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The interaction between troponin C (TnC) and troponin I (TnI) is essential for the regulation of muscle contraction. There are several binding sites for TnI on TnC that are differentially occupied depending on the phase of the contraction/relaxation cycle. TnI and TnC interact in an antiparallel fashion with each other. The C-domain of cTnC and the N-domain region of cTnI(residues 33–70) always in
Modern district heating systems, a carbon lean technology, involves dual usage of the energy due to the possibility to redistribute heat derived from numerous sources, such as industrial processes, refuse incineration, geothermal sources and combined heat and power plants. Such heat source flexibility facilitates the optimal usage of energy resources by varying the amount of purchased heat dependi
Pulse height versus energy calibrations of a Si p-i-n diode and a Au-/n-Si surface barrier detector have been studied for heavy ions with atomic number (Z(1)) from 3 to 79 in a range from 0.1 to 0.8 MeV per nucleon as a function of bias voltage and detector tilting angle. The detector response is simultaneously measured using a time of flight-energy elastic recoil detection analysis set-up with re
Here we present results from a field experiment in a sub-arctic wetland near Abisko, northern Sweden, where the permafrost is currently disintegrating with significant vegetation changes as a result. During one growing season we investigated the fluxes of CO2 and CH4 and how they were affected by ecosystem properties, i.e., composition of species that are currently expanding in the area (Carex rot
Coronary heart disease (CHD) is a common condition associated with a high mortality. There is now growing evidence that erectile dysfunction (ED) in men may be a suitable marker of sub-clinical cardiovascular disease, identifying patients at high risk for future CHD. We investigated the association between CHD risk factors and ED during a period of 25 years, in a population based cohort of men, a
Many concrete dams, and other concrete structures within the hydropower industry are old and in a more or less severe state of degradation. Leaching is, together with freeze-thaw, the most common degradation problem in Swedish hydraulic concrete structures. This report contains a literature survey of concrete leaching, and presents the results of an experimental determination of leaching.
alpha 1-Antitrypsin (AAT), a major endogenous inhibitor of serine proteases, plays an important role in minimizing proteolytic injury to host tissue at sites of infection and inflammation. There is now increasing evidence that AAT undergoes post-translational modifications to yield by-products With novel biological activity. One Such molecule, the C-terminal fragment of AAT, corresponding to resid
Objective: to describe the trends of self-reported past consumption of alcoholic beverages and ethanol intake from 1950. to 1995 within the European Prospective Investigation into Cancer and Nutrition (EPIC). Design: Data-on consumption of beer/cider, wine and liqueur/spirits were obtained age 20, 30 and 40 years to calculate average consumption and retrospectively at ethanol intake for the time p
Individual control and quantification of phosphate removal is desirable in dialysis treatment. Currently, no on-line method exists to quantify phosphate removal. We demonstrate that a multivariate calibration model based on infrared transmission spectra is capable of predicting phosphate, urea, and glucose concentrations at clinically relevant levels. The on-line monitoring of these components by
Parkinson's disease is a devastating neurological condition that affects at least four million people. A striking feature of this disorder is the preferential loss of dopamine-producing neurons in the midbrain. Several aetiological triggers have been linked to Parkinson's disease, including genetic mutations and environmental toxins, but the pathway that leads to cell death is unknown. Recent deve
The aim of this study is to examine the two novels Le Rouge et le Noir and La Chartreuse de Parme in the light of the theory of 'triangular desire', elaborated by René Girard in Mensonge romantique et vérité romanesque (1961). According to this theory, desire in Stendhal's novels – that is desire in a very general sense – is not spontaneous, but derived from a third part, that Girard labels the 'm
