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Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic control that raises the need for effective therapy targeted at the underlying defects in
Objective . To evaluate the clinical performance in a paediatric population of the Lund-Malmo creatinine-based glomerular filtration rate (GFR) prediction equations, primarily developed for adults. Material and methods . Iohexol clearance was used as the gold standard in 85 paediatric Caucasian patients (0.3-17 years; 37 F/48 M). One Lund-Malmo equation was based on age and gender (LM) and one inc
In this paper a particular case of grammatical gender agreement system is discussed, concerning the referent of young females or small children. These referents are grammatically treated as neuter nouns, disregarding their biological sex. This is termed gender disagreement. It is argued here that this is due to the older classification of nouns based on active and inactive distinction, stemming fr
This correspondence deals with the construction of minimum Euclidean distance precoders for multiple-input multiple-output (MIMO) systems with up to four transmit antennas. By making use of a state-of-the-art technique for optimization over the unitary group, we can numerically optimize the MIMO precoders. The correspondence then proceeds by identifying the obtained precoders as well-known lattice
Background: To offer minimized risk-adapted adjuvant treatment on a community and nationwide basis for patients with clinical stage 1 (CS1) nonseminomatous germ-cell testicular cancer (NSGCT). The aim was to reduce the risk of relapse and thereby reducing the need of later salvage chemotherapy while maintaining a high cure rate. Patients and methods: From July 1995 to January 1998, a total of 232
This randomized clinical trial assessed the effectiveness of multisystemic therapy (MST) for 156 youths who met the diagnostic criteria for conduct disorder. Sweden's 3 largest cities and I small town served as the recruiting area for the study. A mixed factorial design was used, with random allocation between MST and treatment as usual groups. Assessments were conducted at intake and 7 months aft
Mature aggrecan is generally C-terminally truncated at several sites in the CS (chondroitin sulfate) region. Aggrecanases and MMPs (matrix metalloproteinases) have been suggested to be responsible for this digestion. To identify whether calpain, a common intracellular protease, has a specific role in the proteolysis of aggrecan we developed neoepitope antibodies (anti-PGVA, anti-GDLS and anti-EDLS
The lectin, phytohaemagglutinin (PHA), from red kidney beans has been shown as an inducer of growth and precocious gastrointestinal (Cl) maturation in suckling animals, thus better preparing piglets for the weaning procedure. PHA exposure results in the release of gut peptide hormones and/or activation of the Cl immune system. The aim of this study was to elucidate the mechanisms of PHA provocatio
Popular Abstract in Swedish Skador i knäleden är vanligt förekommande och främre korsbandsskada drabbar i Sverige årligen mer än 8 per 10 000 personer i åldern 10-64 år. Följderna av skadan kan bli bestående funktionsnedsättning med bl.a. instabilitet, plötsliga och smärtsamma knäledsvikningar och ökad risk för nya skador. Cirka hälften av patienterna utvecklar ledsvikt (artros) 10-15 år efter denThe purpose of this thesis was to increase the understanding of altered movement patterns in individuals with anterior cruciate ligament (ACL) injury in order to improve ACL rehabilitation, and to develop an observational instrument termed Test for Substitution Patterns (TSP) for standardized, quantifiable scoring of altered movement patterns in legs and trunk. In all, 142 participants, 93 with A
A search for long-lived particles is performed using a data sample of 4.7 fb(-1) from proton-proton collisions at a centre-of-mass energy. root s = 7 TeV collected by the ATLAS detector at the LHC. No excess is observed above the estimated background and lower limits, at 95% confidence level, are set on the mass of the long-lived particles in different scenarios, based on their possible interactio
This paper argues that expected utility theory for actions in chancy environments should be formulated in terms of centered chances. The subjective expected utility of an option A may be seen as a weighted sum of the utilities of A in different possible worlds, with weights being the credences that the agent assigns to these worlds. The utility of A in a given world is then definable as a weighted
Changes in agricultural management have been identified as the most probable cause for the decline of Skylark (Alauda arvensis) populations in Europe. However, parasitic infections have not been considered as a possible factor influencing this process. Four hundred and thirty-four Skylarks from the Southern Italy and the Netherlands were screened for haemosporidian parasites (Haemosporida) using t
The larva of codling moth Cydia pomonella (Tortricidae, Lepidoptera) is known as the worm in the apple, mining the fruit for food. We here show that codling moth larvae are closely associated with yeasts of the genus Metschnikowia. Yeast is an essential part of the larval diet and further promotes larval survival by reducing the incidence of fungal infestations in the apple. Larval feeding, on the
In this work the inhomogeneous (zero-phonon line) and homogeneous linewidths and the permanent electric dipole moment change (averaged value of all dipole orientations) for the Ce 4f-5d transition in Y2SiO5 were measured in order to investigate the possibility for using Ce as a sensor to detect the hyperfine state of a spatially close-lying Pr or Eu ion. The experiments were carried out on Ce dope
This paper is concerned with model fitting in the presence of noise and outliers. Previously it has been shown that the number of outliers can be minimized with polynomial complexity in the number of measurements. This paper improves on these results in two ways. First, it is shown that for a large class of problems, the statistically more desirable truncated L-2-norm can be optimized with the sam
This thesis aimed to search for epidemiological evidence supporting the associations of type 2 diabetes mellitus (T2DM) with cancer and autoimmune diseases (ADs) by analysing several Swedish national registries. T2DM shares risk factors with cancer, such as obesity, diet, stress, and physical inactivity. However, it is unclear whether the associations with several types of cancers are due to share
