Filtyp
Foodomics is an emerging probing method of phenotype investigation of the different milk proteins and their subtypes. The polymorphic nature of the β-casein (β-Cn) protein has shown fourteen different protein variants to date in bovines. The analysis of the β-Cn genetic polymorphism from the milk of the crossbred dairy animals is crucial for the quality assurance of the consumers from the various
Data acquisition and integration are vital aspects of circular industrial initiatives and help industries develop balanced coordination with other stakeholders and commitment to circular standards. Small and medium-sized enterprises hesitate to implement the necessary automation and information collection process because of high investment issues. The dairy industry does have a growing need for pr
This paper studies the time-dependent first-in-first-out (FIFO) queuing model with a single intermittently available server and variable-sized bulk arrivals and bulk departures. The time between arrivals, servicing time, and server availability time follows an exponential distribution. The difference-differential equations are used for developing system equations, and the Laplace transforms (L.T.)
This chapter reviews the growing body of epidemiological evidence linking long-term exposure to ambient air pollution with increased risk of dementia, including Alzheimer’s disease (AD) and vascular dementia (VaD). With air pollution now recognized as a potentially modifiable risk factor, the chapter explores mechanistic pathways, such as neuroinflammation and oxidative stress, through which pollu
The increasing complexities and vulnerabilities in globalised supply chains, exacerbated by recent crises such as pandemics, climate change, and geopolitical disruptions, have underscored the urgent need for sustainable and resilient supply chain management. The growing interdependence of global trade networks makes them more susceptible to disruptions, highlighting the importance of digital trans
The European Union (EU) has recently presented several new legal proposals for promoting ecodesign and product labeling. The aim is to harmonize national practices and rules in the EU, to regulate issues like product lifetime and repairability in a more comprehensive way, to introduce new tools like digital product passports, and to introduce labeling schemes for repairability and durability. In p
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.
The androgen receptor (AR) is central in prostate tissue identity and differentiation, and controls normal growth-suppressive, prostate-specific gene expression. It also drives prostate tumorigenesis when hijacked for oncogenic transcription. The execution of growth-suppressive AR transcriptional programs in prostate cancer (PCa) and the potential for reactivation remain unclear. Here, we use a ge
In preclinical studies, p53 loss of function impacts chemotherapy response, but this has not been consistently validated clinically. We trained a TP53-loss phenocopy gene expression signature from pan-cancer clinical samples in the TCGA. In vitro, the TP53-loss phenocopy signature predicted chemotherapy response across cancer types. In a clinical dataset of 3003 breast cancer samples treated with
Despite the average 5-year survival rate exceeding 85%, childhood cancer is still the most common cause of disease-related death among children in Sweden. A cancer diagnosis is profoundly traumatic not only for children themselves, but also for the entire family, particularly the primary caregivers, their parents. This project aimed to investigate the extent to which a childhood cancer diagnosis a
Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease that resists therapy targeting androgen signaling, the primary driver of prostate cancer. mCRPC resists androgen receptor (AR) inhibitors by amplifying AR signaling or by evolving into therapy-resistant subtypes that do not depend on AR. Elucidation of the epigenetic underpinnings of these subtypes could provide important
Forest conservation has emerged as a key strategy to achieve global climate goals, yet many forest-rich countries remain underfunded. Cambodia, despite its extensive forest cover and high deforestation rates, accesses only a small portion of climate finance to support national mitigation efforts. Developing countries such as Cambodia access only a small share of the substantial annual for national
To evaluate the feasibility and acceptability of a therapist-guided, mobile app-assisted behavioural treatment for children and adolescents with chronic tic disorders, compared to videoconference-delivered behaviour therapy for tics. Pilot, single-blind, two-arm randomised controlled trial (RCT). A specialist tic disorder clinic for children and adolescents in Denmark. 30 participants with Tourett
The role of education for school-aged refugee children has evolved throughout history, influenced by time, geopolitical contexts, public perceptions, and ideas about the purposes of education. This article examines refugee education in Finland and Sweden over the past century, focusing on three periods. The first is the 1920s, when newly independent Finland agreed to the migration of large groups
The Aβ42 peptide (APP(672–713)), associated with Alzheimer disease, is highly prone to form amyloid fibrils and has been extensively studied through in vitro experiments. Such experiments represent a basis for understanding the biophysical chemistry of amyloid-related diseases. In this communication, we show that homogeneous primary nucleation in vitro of Aβ42 fibrils is a very rare event, implyin
Hard tissues in biology are typically hierarchical composites. Osteoderms are mineralized dermal structures, widespread in lizards, in which a hyper-mineralized superficial layer, the capping tissue, has recently attracted attention for its unusual structural and mechanical features, with, e.g., moduli reaching those of enamel. Here, a comparative study of osteoderms from six lizard species whose
Ecological network approaches have advanced our understanding of how species interactions influence community and evolutionary dynamics. However, a key limitation is that most network analyses rely solely on visitation data, often overlooking functional aspects of interactions. Here, we combined quantitative (visitation frequency) and qualitative (pollen removal and deposition) components to asses
Housing is crucial for people to flourish, as it is more than shelter and physical infrastructure. The conversation discusses trajectories and ‘variegations’ in universal, decommodified, non-profit housing provision in Scandinavian countries, focusing on Sweden (allmännyttan) and Denmark (almen). It explores how Sweden’s municipal rental housing was transformed by neoliberal market fundamentalism,
Background: Interventions in the form of animal-assisted and nature-based activities are promising for young adults with autism, but there is a knowledge gap concerning the long-term values of these. Aim: The aim was to describe the activity levels in daily life and socioeconomic aspects for young adults with autism one year after a 12-week intervention with animal-assisted and nature-based activi
Background: Proton beam therapy (PBT) offers dosimetric advantages in pediatric radiotherapy by reducing radiation exposure to healthy tissues. However, broad implementation raises important ethical, logistical, and equity considerations, especially in settings with limited access to advanced technologies. Procedure: This position paper by the Paediatric Radiation Oncology Society (PROS) reviews t
