Sökresultat

Our knowledge of the binding sites for neutralizing Abs (NAb) that recognize a broad range of HIV-1 strains (bNAb) has substantially increased in recent years. However, gaps remain in our understanding of how to focus B cell responses to vulnerable conserved sites within the HIV-1 envelope glycoprotein (Env). In this article, we report an immunization strategy composed of a trivalent HIV-1 (clade

Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The

Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in

Phase 3 trials have made major contributions to advances in prostate cancer (PCa). However, funding limitations and excess bureaucracy are now making it difficult to conduct trials.

A prospective clinical cohort study was established to investigate the humoral immune response in middle ear fluids (MEF) and serum against bacterial surface proteins in children suffering from recurrent acute otitis media (rAOM) and chronic otitis media with effusion (COME), using Luminex xMAP technology. The association between the humoral immune response and the presence of Moraxella catarrhali

Excessive sweating is a major ergonomic concern in bicycle helmet use and low wearing rates are suspected to originate, at least partly, from impaired thermal comfort due to accumulated sweat increasing skin wettedness at the head region. As a development from COST Action TU1101 WG4, we introduce a modelling framework for assessing the thermal comfort of bicy-cle helmet use. We predicted local swe

Popular Abstract in Swedish Fantasygenrens många främmande och fantastiska platser ger inte bara handlingen en exotisk kuliss utan är tätt knutna till hur berättelserna är uppbyggda. I Stefan Ekmans doktorsavhandling Writing Worlds, Reading Landscapes: An Exploration of Settings in Fantasy visas hur miljön i fantasy är lika viktig som persongalleriet och intrigen. Fantasy är en genre som sätter väIn fantasy literature, the setting is as important to the story as are characters and plot; but although many fantasy scholars have pointed this out, there is very little criticism that explores the role of the setting in fantasy. The aim of this study is to use a topofocal (place-focused) perspective to examine four aspects of the fantasy setting, including the way in which settings function in t

There are many benefits offered by integrated enterprise computer systems. There are a growing number of options available to obtain such management information system support. A major problem when selecting Enterprise Information Systems, in special ERP systems, is how to deal with the great diversity of options as well as the number of criteria used to evaluate each alternative. There is an impl

Popular Abstract in Swedish I litteraturen kring marknadsföring av tjänster har det i flera sammanhang diskuterats hur tjänster baserade på kombinationer av kundmedverkan och teknologi kan erbjudas till kunden. Exempel som behandlats är bankers uttagsautomater, självbetjäning på bensinstationer och automatiska banktjänster över telefon. Innan man kan presentera sådana rekommendationer behövs det gThis doctoral thesis deals with consumers’ attitudes towards serving them-selves with machines rather than being served by personnel. Its aim is to contribute to the theory of perceived service quality by providing a better understanding of customers’ attitudes and preferences when using technology-based self-service. In addition to aspects of service dealt with by traditional service-quality rese

Objective: The prognostic influence of neuroendocrine (NE) differentiation in prostate cancer patients is not yet properly established. In a series of primary hormone-naive prostate cancers from a patient population that underwent radical prostatectomy, we wanted to determine the relationship between NE phenotype expression and Gleason sum, disease stage, and serum PSA concentration. Methods: Ch

Background: Current therapies for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis are limited by toxicity. Objective: To compare pulse cyclophosphamide with daily oral cyclophosphamide for induction of remission. Design: Randomized, controlled trial. Random assignments were computer-generated; allocation was concealed by faxing centralized treatment assignment to providers at the

Background & Aims: There is no medical treatment of proven benefit for primary sclerosing cholangitis. This study aimed at studying the effect of a higher dose of ursodeoxycholic acid than previously used on survival, symptoms, biochemistry, and quality of life in this disease. Methods: A randomized placebo-controlled study was performed in tertiary and secondary gastroenterology units. A tota

The etiology of Langerhans cell histiocytosis (LCH), a disease characterized by uncontrolled proliferation of Langerhans cells, is unknown. Although some believe that LCH is reactive, others support a neoplastic origin. We tested the hypothesis that LCH is neoplastic by investigating potential consistent chromosomal aberrations in LCH cells. We used multiparameter DNA flow cytometry to analyze the

The interest in phasor measurement technology has reached a peak in recent years, as the need for the best estimate of the power system's state is recognized to be a crucial element in improving its performance and its resilience in the face of catastrophic failures. In most countries installing the phasor measurement units (PMUs) and getting to know the PMU system behavior through continuous obse

We present experimental results from an extensive investigation of a Ni-like Mo X-ray laser pumped in the transient regime and GRIP configuration (GRazing Incidence Pumping). The pump laser is a 10 Hz, 1 J, Ti:Sa laser system. The main diagnostic is a monochromatic near-field imaging system with a 1.7 micron spatial resolution that shows the soft x-ray laser source size and position relative to th

OBJECTIVE: To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS: We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia: 66 ± 10 years, 58% M) classified for positivity (±) of amyloid (A) ([18F]Flor