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Field-level clothianidin exposure affects bumblebees but generally not their pathogens

Neonicotinoids are implicated in bee declines and laboratory studies imply that they impair the bee immune system, thereby precipitating a rise in pathogen levels. To establish whether such synergisms reduce bee performance in real-world agricultural landscapes, we analysed the microbial composition of the bumblebee (Bombus terrestris) samples from our recent landscape study on the impacts of fiel

Divergent effects of metformin on an inflammatory model of Parkinson’s disease

The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN), the main structure affected in Parkinson’s disease (PD), has not yet been studied in depth. Inflammation is a key feature of PD and it may play a

Disease-specific Hospitalizations among 5-Year Survivors of Hepatoblastoma : A Nordic Population-based Cohort Study

Introduction: The long-term risk of somatic disease in hepatoblastoma survivors has not been thoroughly evaluated in previous studies. In this population-based study of 86 five-year HB survivors, we used inpatient registers to evaluate the risk for a range of somatic diseases.Methods: In total, 86 five-year survivors of hepatoblastoma were identified in the Nordic cancer registries from 1964 to 20

Fluorine Abundances in the Globular Cluster M4

We present chemical abundances for the elements carbon, sodium, and fluorine in 15 red giants of the globular cluster M4, as well as six red giants of the globular cluster ω Centauri. The chemical abundances were calculated in LTE via spectral synthesis. The spectra analyzed are high-resolution spectra obtained in the near-infrared region around 2.3 μm with the Phoenix spectrograph on the 8.1 m Ge

Caregiving and infants' neurodevelopment in rural Costa Rica : Results from the Infants’ Environmental Health Study (ISA)

Early caregiving is one of the strongest influences on children's development, and among the most significant modifiable environmental factor. The aim of this study was to explore the association between quality of caregiver-infant interactions and neurodevelopment of infants living in banana-growing communities in rural Costa Rica characterized as having environmental toxic exposures. Home visits

Toward Reliable Lipoprotein Particle Predictions from NMR Spectra of Human Blood : An Interlaboratory Ring Test

Lipoprotein profiling of human blood by 1H nuclear magnetic resonance (NMR) spectroscopy is a rapid and promising approach to monitor health and disease states in medicine and nutrition. However, lack of standardization of measurement protocols has prevented the use of NMR-based lipoprotein profiling in metastudies. In this study, a standardized NMR measurement protocol was applied in a ring test

Brain responses to negated and affirmative meanings in the auditory modality

Negation is frequently used in natural language, yet relatively little is known about its processing. More importantly, what is known regarding the neurophysiological processing of negation is mostly based on results of studies using written stimuli (the word-by-word paradigm). While the results of these studies have suggested processing costs in connection to negation (increased negativities in b

Quantification of glutathione transverse relaxation time T2 using echo time extension with variable refocusing selectivity and symmetry in the human brain at 7 Tesla

Glutathione (GSH) is an endogenous antioxidant implicated in numerous biological processes, including those associated with multiple sclerosis, aging, and cancer. Spectral editing techniques have greatly facilitated the acquisition of glutathione signal in living humans via proton magnetic resonance spectroscopy, but signal quantification at 7 Tesla is still hampered by uncertainty about the gluta

Halogen-Bonded Hole-Transport Material Suppresses Charge Recombination and Enhances Stability of Perovskite Solar Cells

Interfaces play a crucial role in determining perovskite solar cells, (PSCs) performance and stability. It is therefore of great importance to constantly work toward improving their design. This study shows the advantages of using a hole-transport material (HTM) that can anchor to the perovskite surface through halogen bonding (XB). A halo-functional HTM (PFI) is compared to a reference HTM (PF),

Peripheral arterial disease (PAD) – A challenging manifestation of atherosclerosis

The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and signs may show great variation. As all grades of PAD are linked to both an increased risk for cardiovascular complications and adverse limb events, awareness of the condition and knowledge about diagnostic measures, prevention and treatment is crucial. This article presents in a condensed form information on P

Neural and behavioural mechanisms underlying the processing of negated meanings : Words, pictures and sentences

This thesis combines a number of methodologies and measures in order to address the processing of two types of negation (with not and un) in relation to each other and to non-negated affirmative meanings. The four investigations in this thesis target the processing of these meanings at different levels, namely the word level (Study 1) and sentence level (Studies 2–4). In two artificial language le

The generalisability of randomised clinical trials : an interim external validity analysis of the ongoing SENOMAC trial in sentinel lymph node-positive breast cancer

Purpose: None of the key randomised trials on the omission of axillary lymph node dissection (ALND) in sentinel lymph-positive breast cancer have reported external validity, even though results indicate selection bias. Our aim was to assess the external validity of the ongoing randomised SENOMAC trial by comparing characteristics of Swedish SENOMAC trial participants with non-included eligible pat

Evaluation of in vitro testing strategies for hazard assessment of the skin sensitization potential of “real-life” mixtures : The case of henna-based hair-colouring products containing p-phenylenediamine

Background: Allergic contact dermatitis caused by henna-based hair-colouring products has been associated with adulteration of henna with p-phenylenediamine (PPD). Objectives: To develop a testing approach based on in vitro techniques that address key events within the skin sensitization adverse outcome pathway in order to evaluate the allergenic potential of hair-colouring products. Methods: The

Macrocycle ring deformation as the secondary design principle for light-harvesting complexes

Natural light-harvesting is performed by pigment–protein complexes, which collect and funnel the solar energy at the start of photosynthesis. The identity and arrangement of pigments largely define the absorption spectrum of the antenna complex, which is further regulated by a palette of structural factors. Small alterations are induced by pigment–protein interactions. In light-harvesting systems

Boosting aerosol surface effects : strongly enhanced cooperative surface propensity of atmospherically relevant organic molecular ions in aqueous solution

The effects of atmospheric aerosols are key uncertainties in climate models. One reason is the complex aerosol composition which includes a relatively large fraction of organics. Another reason is the small size of aerosols, which makes surface effects and processes important. These two factors make surface-active organics relevant for atmospheric aerosols, as they can affect crucial processes, su

High gas-pressure apparatus for nonlinear X-ray propagation and reshaping via stimulated X-ray Raman scattering

We describe an experimental setup for non-linear interaction and propagation of ultrashort and intense x-ray free-electron laser (XFEL) pulses in a dense gas. It allows one to provide high, but adjustable, target-gas pressures of up to 6 bar within a vacuum environment of 3∙10− 3 mbar or better. The setup enables investigation of intense x-ray propagation in an optically thick medium with minimal

Mapping geosystem services potential for urban climate resilience : A case study from Malmö, Sweden

Urban climate resilience planning often overlooks the subsurface, despite its potential to mitigate flooding, heat stress, and drought. To demonstrate these potentials, we developed thematic Geosystem Service (GS) maps for Malmö, Sweden, to support the integration of the subsurface into climate adaptation strategies. This study identifies GS relevant to the local context, proposes indicators for m