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A high resolution TPC is the main option for a central tracking detector at the future International Linear Collider (ILC). It is planned that the MPGD (Micro Pattern Gas Detector) technology will be used for the readout. A Large Prototype TPC at DESY has been used to test the performance of MPGDs in an electron beam of energies up to 6 GeV. The first step in the technology development was to demo
Background: Studies on leisure time physical activity as risk factor or protective factor for knee or hip osteoarthritis (OA) show divergent results. Longitudinal prospective studies are needed to clarify the association of physical activity with future OA. The aim was to explore in a prospective population-based cohort study the influence of leisure time physical activity on severe knee or hip OA
The present study focuses on the acquisition of subject-verb agreement in number in spoken French. We compare production and comprehension of singular and plural verb forms in French monolingual and French-Swedish bilingual children (n=58) aged from five to ten years. Overall, the results demonstrate that subject-verb agreement in number is a challenge to all French-speaking children, be it monoli
In male birds, testosterone (T) plays an important role in aggressive and mate-attraction behaviour. In the cooperatively breeding Seychelles warbler, Acrocephalus sechellensis, extra-group copulations (EGCs) occur frequently, but are not accompanied by sexual courtship displays as in within-pair copulations. Paternity is nearly always gained by primary males. We investigated whether T levels and
Several studies have been done in Europe to evaluate exposure to dust and fumes in the rubber industry. However, different aerosol sampling devices have been used which perform differently depending on the environmental conditions and particle size distribution. To compare measurements of rubber dust and fumes among countries and surveys we initiated a field comparison of personal inhalable sample
We have identified a novel von Willebrand factor/fibrinogen/selectin-independent, platelet adhesion-promoting function of vascular PG-M/versicans that may be relevant in normal venous thrombosis and critical in atherosclerotic conditions. A purification scheme was devised to obtain vascular versicans, which by biochemical, immunochemical, and ultrastructural means were asserted to be 1) composed p
Infantile malignant osteopetrosis (IMO) is caused by lack of functional osteoclasts leading to skeletal abnormalities, blindness due to compression of the optic nerves, bone marrow (BM) failure and early death. In most patients TCIRG1, a proton pump subunit essential for bone resorption, is mutated. Oc/oc mice represent a model for IMO due to a deletion in Tcirg1 and die around 4 weeks. To determi
Human antibodies generated in vitro may be highly valuable for diagnostic and therapeutic purposes. For a long time most human antibodies produced in vitro have been of the IgM isotype with rather low affinities. In this thesis a method for production of IgG switched antigen-specific human antibodies is presented. This is a two step protocol, in which the first step is a selection procedure of don
Resonant Auger electron spectra of core excited O-3 (O(F)1s(-1) 2b(1)(1)) are presented for the first time. The photoionization valence spectrum with sample purity and resolution superior to those published is presented. The first direct experimental evidence for the (C) over tilde (2) B-1 state of O-3(+) is found. Ab initio calculations of the resonant Auger electron (RAE) spectrum have been perf
There is still no universal model for analysing and predicting coastal evolution and its governing processes on yearly to decadal time scales. Instead, depending on the nature of the problem and project objectives, there is a wide range of models available, each focusing on the problem complex from a specific standpoint. The present paper gives an overview of available numerical model types. A dif
Objective. Studies in mice suggest that plasma apoM is lowered in hyperinsulinaemic diabetes and that apoM stimulates formation of pre-beta-HDL. Pre-beta-HDL is an acceptor of cellular cholesterol and may be critical for reverse cholesterol transport. Herein, we examined whether patients with type 2 diabetes have reduced plasma apoM and whether apoM is associated with pre-beta-HDL formation and ce
Objective: Fasting insulin concentrations are often used as a surrogate measure or insulin resistance. We investigated the relative contributions Of fasting insulin and insulin resistance to cardiometabolic risk and preclinical atherosclerosis. Design and methods: The Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort consists of 1326 European non-diabetic. overall h
Many industrial applications use flame impingement to obtain high heat-transfer rates. An analytical expression for the convective part of the heat transfer of a flame jet to a plate is derived. Therefore, the flame jet is approximated by a hot inert jet. In contradiction with existing convective heat-transfer relations, our analytical solution is applicable not only for large distances between the j
Avian malaria parasites are supposed to exert negative effects on host fitness because these intracellular parasites affect host metabolism. Recent advances in molecular genotyping and microscopy have revealed that coinfections with multiple parasites are frequent in bird-malaria parasite systems. However, studies of the fitness consequences of such double infections are scarce and inconclusive. W
The aim of this study was to optimize the use of BMD measurements in case finding strategies. The use of clinical risk factors with and without BMD was explored in a random sample of the Sheffield female population greater than or equal to75 years of age. The use of clinical risk factors alone could identify women well above or well below a threshold of fracture risk. BMD assessment can be confine
Background The aim of the Nordic Diltiazem (NORDIL) Study was to compare patients with essential hypertension receiving calcium-antagonist-based treatment with diltiazem and similar patients receiving conventional diuretic/beta-blocker-based treatment, with respect to cardiovascular morbidity and mortality. Objective To assess the influence of age, sex, severity of hypertension and heart rate on t
Vibrationally resolved N2+ (B–X) (1–2) and (0–1) emission bands were recorded after photoexcitation of N2 in the 20–46 eV energy range. The branching ratio between these transitions reveals strong non-Franck–Condon effects. Ab initio calculations using a configuration interaction method based on Kohn–Sham orbitals indicate that the autoionisation of certain superexcited states is responsible for s
