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BackgroundMultigene expression assays for molecular subtypes and biomarkers can aid clinical management of early invasive breast cancer. Based on RNA-sequencing we aimed to develop single-sample predictor (SSP) models for conventional clinical markers, molecular intrinsic subtype and risk of recurrence (ROR).MethodsA uniformly accrued breast cancer cohort of 7743 patients with RNA-sequencing data

The Cretaceous-Paleogene (K-Pg) mass extinction is marked globally by elevated concentrations of iridium, emplaced by a hypervelocity impact event 66 million years ago. Here, we report new data from four independent laboratories that reveal a positive iridium anomaly within the peak-ring sequence of the Chicxulub impact structure, in drill core recovered by IODP-ICDP Expedition 364. The highest co

Microorganisms are important sources of diverse intracellular and extracellular biopolymers havingdifferent functions such as serving as carbon and energy reserves, or as protective layers around the cells in theform of capsules and/or biofilms. They have also found use in foods, medicine and other industrial applications.Research on understanding the synthesis of several biopolymers as well as th

Food additives (e.g. artificial sweeteners, emulsifiers, dyes, etc.) are ingested by billions of individuals daily. Some concerning results, mainly derived from animal and/or cell-based experimental studies, have recently emerged suggesting potential detrimental effects of several widely consumed additives. Profiles of additive exposure as well as the potential long-term impact of multiple exposur

This document summarises the proposal of the LHC Dark Matter Working Group on how to present LHC results on s-channel simplified dark matter models and to compare them to direct (indirect) detection experiments.

Is there a universal hierarchy of the senses, such that some senses (e.g., vision) are more accessible to consciousness and linguistic description than others (e.g., smell)? The long-standing presumption in Western thought has been that vision and audition are more objective than the other senses, serving as the basis of knowledge and understanding, whereas touch, taste, and smell are crude and of

This paper will approach the topic “What does heritage change?” by looking at the perspectives and experiences of a special category of heritage-makers, namely so-called “transmitters of intangible cultural heritage” (feiwuzhi wenhua yichan chuancheng ren) in China. It will explore the processes of heritagization and will ask whether, and what, heritage status changes when it comes to these indivi

Diversity in the genetic profile between individuals and specific ethnic groups affects nutrient requirements, metabolism and response to nutritional and dietary interventions. Indeed, individuals respond differently to lifestyle interventions (diet, physical activity, smoking, etc.). The sequencing of the human genome and subsequent increased knowledge regarding human genetic variation is contrib

Drought is predicted to increase in the future due to climate change, bringing with it myriad impacts on ecosystems. Plants respond to drier soils by reducing stomatal conductance in order to conserve water and avoid hydraulic damage. Despite the importance of plant drought responses for the global carbon cycle and local and regional climate feedbacks, land surface models are unable to capture obs

This doctoral thesis in computational statistics utilizes both Monte Carlo methods(approximate Bayesian computation and sequential Monte Carlo) and machine­-learning methods (deep learning and normalizing flows) to develop novel algorithms for infer­ence in implicit Bayesian models. Implicit models are those for which calculating the likelihood function is very challenging (and often impossible),

Oats (Avena sativa) are a versatile cereal crop cultivated worldwide. Accounting for 2% of global grain production, they rank as the seventh most important cereal. Approximately 23 million tonnes of oat grain is produced annually, with the majority stemming from spring-sown cultivars in Canada, Russia, and Northern Europe. Although used mostly for animal feed, oats have increased in their populariOats (Avena sativa) is a versatile crop grown worldwide for animal feed and human consumption. Humanoat consumption has recently risen due to its various health benefits. However, oats are susceptible toFusarium head blight (FHB) caused by various Fusarium fungi. FHB reduces yield and leads to mycotoxinaccumulation. The most commonly reported mycotoxins in oat are trichothecenes deoxynivalenol (DO

In this thesis, lipid biosynthesis is discussed focussing on the genes and enzymes involved in the final step of storage lipid synthesis, on the enzyme phospholipase A2, and on cell membrane lipid homeostasis. The investigation of lipid metabolism revealed that in Saccharomyces cerevisiae, there are four genes that are essential for the final step of storage lipid biosynthesis; ARE1, ARE2, DGA1, a

Popular Abstract in Swedish Behandlingsideologier och arbetsmodeller avlöser varandra snabbt i dagens samhälle. Att hänga med i det nya och samtidigt försvara det arbete som man gör eller tidigare gjort är en problematik som allt fler ställs inför. I spelet mellan olika inriktningar byggs det upp en argumentation. I denna avhandling analyseras hur anställda vid en psykiatrisk vårdinstitution, specTreatment ideologies and working models replace each other quickly in today's society. During the 1980s a dramatic dismantling of the psychiatric institutions occurred. The health care system was supposed to be transferred to non-institutional care. This was, however, not possible for all groups of patients. At an institution, specialized in so called demanding patients and patients who received c

A particular focus in this paper is the delicate issue of possible over-production of European films, a situation which has either been spelled out or implied in a number of reports, chapters, books and doctoral dissertations on European cinema during the last decade. In a 2014 eight page briefing (referenced below), for instance, it was suggested that between 2001 and 2008 total investment in EU

Wheat bran is a by-product from the production of wheat flour. Nowadays wheat bran is mostly used as feed for animals, in the food and baking industry or it is simply burned in open air. However, wheat bran could be used in biorefineries for production of value-added products such as bioplastics, biofuels and chemicals as a substitute for fossil feedstocks as petroleum. Since wheat bran is an agri

The widespread consequences of climate change are becoming more and more evident around the world and are raising crucial awareness to world leaders that a sustainable transition is direly needed to mitigate against disastrous climatic events. In Australia, in early 2020, these events took the form of some of the most devastating and largest forest fires the country has ever seen. This devastation

In an effort to mitigate global climate change, the REDD+ mechanism (an acronym for ‘Reduced Emissions from Deforestation and Forest Degradation plus the role of conservation, sustainable management of forests and enhancement of forest carbon stock’) continues to be put forward as an attractive carbon sequestration and forest conservation tool. The Democratic Republic of the Congo (DRC), hosting m

In recent years the railway has received a lot of negative publicity thanks to the large amount of delay hours that occurs during winter conditions and especially at snowfall. In our railway network, the points are the most targeted problem components were snow and ice cause the most problems. Due to its moving parts and low tolerances for disorder, a few millimeters of gap between the rails is en