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A new implementation of the coupled cluster singles and doubles with approximate triples correction method [CCSD(T)] using Cholesky decomposition of the orbital energy denominators is described. The new algorithm reduces the scaling of CCSD(T) from N-7 to N-6, where N is the number of orbitals. The Cholesky decomposition is carried out using simple analytical expressions that allow us to evaluate
Electron-ion-ion coincidence measurements of sulfur dioxide at discrete resonances near the O 1s ionization edge are reported. The spectra are analyzed using a model based upon molecular symmetry and on the geometry of the molecule. We find clear evidence for molecular alignment that can be ascribed to symmetry properties of the ground and core-excited states. Configuration interaction (CI) calcul
This review summarizes the knowledge on striated domains, which are ordered assemblies of transmembrane peptides and lipids under gel-state conditions. The structure, mechanism of function and utility of this system as a model for domain formation is described, resulting in a molecular description of the domains and a discussion on the relevance of these insights for the function/formation and str
Objective: The pathogenesis and clinical significance of true umbilical cord knots remain controversial. Here, we tested the hypothesis of the presence of congenital oral mucosal changes in newborns with true umbilical cord knots. Study design: Seven consecutive infants with true umbilical cord knots and 50 gestational age- and sex-matched controls were enrolled. The proportion of oral frenulum ab
Objective: To evaluate the effects of eccentric isokinetic training on knee range of motion (ROM) of healthy subjects. Methods: The knee extensor and flexor isokinetic peak torques and ROM of flexion/extension and varus/valgus knee movements during gait of 18 healthy men (21.7 +/- 2.2 years; 1.73 +/- 0.10m; 68.7 +/- 9.4kg; body mass index: 22.6 +/- 2 kg/m(2)) were analyzed, before and after six we
Idiopathic pulmonary fibrosis is characterized by the accumulation of fibroblasts/myofibroblasts and aberrant remodeling of the lung parenchyma. However, the sources of fibroblasts in IPF lungs are unclear. Fibrocytes are circulating progenitors of fibroblasts implicated in wound healing and fibrosis. In this study we evaluated evidence for the presence of fibrocytes in the lung of patients with i
INTRODUCTION: Calcitonin gene-related peptide (CGRP) is a neuronal messenger in intracranial sensory nerves and is considered to play a significant role in migraine pathophysiology. MATERIALS AND METHODS: We investigated the effect of the CGRP receptor antagonist, telcagepant, on CGRP-induced cranial vasodilatation in human isolated cerebral and middle meningeal arteries. We also studied the expre
Background. Arterial spin labeling is an MR imaging technique that measures cerebral blood flow (CBF) noninvasively. The aim of the study is to assess the diagnostic performance of arterial spin labeling (ASL) MR imaging for differentiation between high-grade glioma and low-grade glioma. Methods. Cochrane Library, Embase, Medline, and Web of Science Core Collection were searched. Study selection e
Introduction: Understanding how hematopoietic stem- and progenitor cells (HSPCs) are regulated is of central importance for the development of new therapies for blood disorders and for regenerative medicine. Traditionally, however, HSPC regulation has been studied in model systems, and little is known about the situation in vivo in humans. Methods: To learn how HSPCs are regulated under native con
Innovation är en kraft som står bakom förändringen i vår vardag. Till exempel att prata med någon på andra sidan jordklotet med en mobil eller beställa dina matvaror eller skor på din smarta mobil. Det var otänkbart för mindre än 40 år sedan. Vi vill naturligtvis att innovationer i vårt samhälle ska fortsätta förbättra våra liv. Men innovationsverksamhet och att generera nya produkter, tjänster, aInnovation measurement and metrics have fascinated scholars from several disciplines over the last decade. Allthese diverse contributions, however, have resulted in a current state of knowledge that is signified by largenumbers of articles without clear integration and synthesis. Therefore, this thesis aims to increase thetheoretical, empirical, and practical understanding of innovation measuremen
In a regulatory context, skin sensitization hazard and risk evaluations of manufactured products and their ingredients (e.g. cosmetics) are mandatory in several regions. Great efforts have been made within the field of 21st Century Toxicology to provide non-animal testing approaches to assess the skin allergy potential of materials (e.g. chemicals, mixtures, nanomaterials, particles). Mechanistic
Changes in temperature have occurred throughout Earth's history. However, current warming trends exacerbated by human activities impose severe and rapid loss of biodiversity. Although understanding the mechanisms orchestrating organismal response to climate change is important, remarkably few studies document their role in nature. This is because only few systems enable the combined analysis of ge
Observational learning has shown to be a successful intervention for writing. Up until now, however, studies have only been performed with normal-hearing participants, usually highschool or university students. Additionally, there have been conflicting results in whether subjective text quality correlates with one or more objectively measured text characteristics. In this study, we measured the ef
En berättelse om entreprenaden bakom byggandet av Lunds domkyrka. Den lokala aristokratins erfarenhet av entreprenader, anskaffandet av arbetskraft och Harald Blåtands första etablering i Lund inleder redogörelsen. Den första byggnaden på kyrkoplatsen, troligen ett kloster, får byggnadsmaterialet fråm Helsingborg- och Ystadstrakten. Den stående domkyrkans sten kommer från Hallaröd/Munkarp. En fyll
In the framework of robotics, Reinforcement Learning (RL) deals with the learning of a task by the robot itself. This paper presents a hierarchical planning approach in which the robot learns the optimal behavior for different levels. For high-level discrete actions, Q-learning was chosen, whereas for the low level we utilize Policy Improvement with Path Integrals (PI^2) algorithm to learn the par
OBJECTIVE(S):: We explored incidence, predictors, and long-term prognosis of hospital admissions attributed to reflex syncope and orthostatic hypotension. METHODS:: We analyzed a cohort of 32?628 individuals (68.2% men; age, 45.6?±?7.4 years) without prevalent cardiovascular disease over a follow-up period of 26.6?±?7.5 years. RESULTS:: One thousand and fourteen persons (3.1%, 1.2 per 1000 person-
Photosystem I (PSI) is combined with Desulfovibrio gigas hydrogenase for the bioelectrocatalytic photosynthesis of hydrogen at an electrode surface. The activity of these two biocatalysts is linked by two redox polymers; a redox polymer with a relatively positive potential (loaded with an Os complex) is able to reduce PSI and thus facilitates the production of photoexcited electrons, whereas redox
The impact of soil metal pollution on plant communities has been studied extensively in the past.However, very little is known about the fungal species that co-occur with these plant communities onmetal polluted soils.We characterized the belowground fungal community in a heavy metal polluted anda non-polluted soil using 454 pyrosequencing. The fungal communities at both study sites were shown toc
