Filtyp
The apparent permeability index is widely used as part of a general screening process to study drug absorption, and is routinely obtained from in vitro or ex vivo experiments. A classical example, widely used in the pharmaceutical industry, is the in vitro Caco-2 cell culture model. The index is defined as the initial flux of compound through the membrane (normalized by membrane surface area and d
PURPOSE: To evaluate, preclinically, the potential for dose escalation of continuous, hyperfractionated, accelerated radiation therapy (CHART) for non small-cell lung cancer (NSCLC), we examined the strategy of omission of elective nodal irradiation with and without the application of three-dimensional conformal radiation technology (3DCRT). METHODS AND MATERIALS: 2D, conventional therapy plans we
The decay of core-excited electronic states in free 1,3 trans butadiene molecules has been studied using high-resolution synchrotron radiation and electron spectrometry. The core-level energy shift between the terminal and central carbon atoms is 0.64 eV making selective excitation of core electrons from these atoms possible. Resonant excitation to the au(*) valence state leads to autoionizing dec
Background Postoperative policies of "wait-and-see" and radiotherapy for low-grade glioma are poorly defined. A trial in the mid 1980s established the radiation dose. In 1986 the EORTC Radiotherapy and Brain Tumor Groups initiated a prospective trial to compare early radiotherapy with delayed radiotherapy. An interim analysis has been reported. We now present the long-term results. Methods After s
The influence of temperature, salts, pH, and various pre-treatments and cleaning on the nanofiltration (NF) performance of thin-film polyamide (PA) composite membranes has been investigated. The change in membrane performance was correlated to membrane swelling or/and electroviscous friction. Aspects of costs and energy demand while using NF at elevated temperatures were also evaluated. The increa
Commodity currencies have been stood against fiat money in the discourses on the history of money, implying a development from primitive forms of money – which needed anchor in a real commodity to gain acceptance, for instance gold, silver or copper – to a more sophisticated monetary regime based solely on confidence and trust. This paper argues that the idea of a gradual replacement of the former
In 2019 the first neutrons will be fired at the ESS plant, at least to its present plan, located in the outskirts of Lund, the brightest neutron facility in the world. In the scientists’ self-images, this kind of high technology and international cooperative knowledge production is entitled Big Science or Global Science. The concept “technoscience” isn’t used. This chapter will discuss if the conc
Sustainable products have arrived on the market and faced competition with traditional products with one extra challenge: they normally tend to be more expensive than traditional ones. Customers are yet to pay more for these products as they are alerted for environmental impacts. However, the gap between knowledge and action is being decreased slowly. One of the factors for this sluggish behavior
Gender inflection for animated nouns in Italian presents challenges influenced by societal pressures and linguistic structure, especially in morphologically complex words like compounds. The study investigates gender inflection distribution in compounds with capo- compared to other nouns (i.e., occupations traditionally performed by women, by men, and the word capo in isolation), exploring the int
Background: Information on bleeding phenotype in nonsevere hemophilia may be used to determine target factor levels for prophylaxis or gene therapy in severe hemophilia. Objectives: To assess the association between endogenous factor level and bleeding phenotype in children with nonsevere (factor [F]VIII/FIX activity 1%-25%) hemophilia A (HA) and B without prophylaxis. Methods: Data on annualized
Background: Modern drug-eluting stents have seen significant improvements, yet still create a rigid cage within the coronary artery. There is a 2% to 4% annual incidence of target lesion failure (TLF) beyond 1 year, and half of the patients experience angina after 5 years. The DynamX bioadaptor is a sirolimus-eluting, thin (71 µm) cobalt-chromium platform with helical strands that unlock and separ
Carbon emissions from buildings have inherently dynamic characteristics since buildings evolve over time. Most previous studies, however, implemented static building carbon regimes, ignoring the temporal variation of many factors that govern carbon emissions of buildings. This research explores the influences of four dynamic factors acting on building carbon emissions: dynamic climate change data,
Active learning is increasingly implemented in higher education, yet students' perspectives on this pedagogical approach remain diverse. This study explores geoscience students' views on active learning within a course at the University of Bergen (UiB) and in relation to their broader study program. Through longitudinal qualitative interviews with two student cohorts, we identified seven main cate
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
This chapter delves into the evaluation of national innovation policies through a case study of the Brazilian National Innovation Policy (NIP). Assessing these policies poses several challenges, including the difficulty of defining and measuring policy outcomes, the scarcity of reliable data, and the intricacies of interactions among various stakeholders involved in the policy. Additionally, polit
Single cell sequencing technologies (scRNA-seq, scATAC-seq, etc.) have revolutionized the study of complex tissues and unique organisms, providing researchers with a much needed species agnostic tool to study biological processes at the cellular level. To date, scRNA-seq technologies are expensive, require sufficient cell quantities, and need biological replicates to avoid batch effects or artifac
α-Galactosidases are important industrial enzymes for hemicellulosic biomass degradation or modification. In this study, six novel extracellular α-galactosidases from Penicillium subrubescens were produced in Pichia pastoris and characterized. All α-galactosidases exhibited high affinity to pNPαGal, and only AglE was not active towards galacto-oligomers. Especially AglB and AglD released high amou
Bakgrund: En förälders död är en av de mest dramatiska händelser som kan drabba barn och ungdomar ochdet kan påverka dem på många olika sätt.Syfte: Att undersöka hur ungdomar som förlorat en förälder inkluderades i ett stödprogram för sörjandefamiljer och hur deras deltagande tog sig uttryck. Metod: En etnografisk fältstudie där data samlades in med hjälp av observationer, semi-struktureradeinterv
Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (ROR). A cohort of 7743 patients was divided into training and test set. We trained SSPs for subtypes and ROR assigned by nearest-centroid (NC) methods and SSPs
