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Background: Young people's daily lives and social interactions changed remarkably during the COVID-19 pandemic as schools and cinemas closed, leisure activities were cancelled, and gatherings were regulated. Questions have been raised by the media, schools, policy makers, and research communities about the effect on young people's online behaviors. Objective: This cross-sectional study aimed to st

We present the archaeological discovery and microscale X-ray Computed Tomography (µCT) scanning of a silver coin purse lost in a medieval shipwreck while the king who issued many of the coins was aboard. The find demonstrates that shipwrecks are extraordinary repositories of historical information, in this case providing insight into one of the most important and dramatic events of medieval Scandi

Resting heart rate is a determinant of cardiac output and physiological homeostasis. Although a simple, but critical, parameter, this vital sign predicts adverse outcomes, including mortality, and development of diseases in otherwise normal and healthy individuals. Temporal changes in heart rate can have valuable predictive capabilities. Heart rate can reflect disease severity in patients with var

Complement C3 was originally regarded as a serum effector protein, although recent data has emerged suggesting that intracellular C3 can also regulate basic cellular processes. Despite the growing interest in intracellular C3 functions, the mechanism behind its generation has not been demonstrated. In this study we show that C3 can be expressed from an alternative translational start site, resulti

TRP channels sense temperatures ranging from noxious cold to noxious heat. Whether specialized TRP thermosensor modules exist and how they control channel pore gating is unknown. We studied purified human TRPA1 (hTRPA1) truncated proteins to gain insight into the temperature gating of hTRPA1. In patch-clamp bilayer recordings, ∆1-688 hTRPA1, without the N-terminal ankyrin repeat domain (N-ARD), wa

Recent studies highlight the importance of lipotoxic damage in aortic cells as the major pathogenetic contributor to atherosclerotic disease. Since the STE20-type kinase STK25 has been shown to exacerbate ectopic lipid storage and associated cell injury in several metabolic organs, we here investigate its role in the main cell types of vasculature. We depleted STK25 by small interfering RNA in hum

Monitoring a microservice system may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. In this study, we explore deep learning (DL) solutions for detection of anomalous system's behavior based on collected monitoring data that consists of applications' and systems' performance metrics. The study is conducted in a collaboratio

This chapter provides conceptual and empirical foundations for smart specialization, a policy approach of far-reaching importance in the European context. We interpret the very notion as “diversified” specialization into areas of existing or potential competitive advantage, which differentiates a region/nation from others. “Smart” relates to the identification of these areas through a process of e

Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-ge

Space Syntax theory is a methodological framework for describing and analysing the relationships between spaces and buildings. The fundamental building blocks of Space Syntax are called axial lines, which represent lines of sight from a specific point in space. These lines can then be used to quantitatively analyse the integration (or attractiveness) of an area. However, many public squares and tr

Newspapers and media have always played a critical role in society and have come to shape the way we reflect and perceive news and societal issues. Journalists are conveyer of a message and act as a moderator to shape and set the agenda for the public opinion and the public discourse. This research paper examines the media portrayal of refugees from Ukraine and Syria through pictures. These confli

I vilket inkomstslag carried interest beskattas har fått stor medial uppmärksamhet då det ofta handlar om betydande belopp. Vilket inkomstslag carried interest beskattas i har stor inverkan på skattskyldigs skattebörda och även hur mycket skatteintäkter som inbringas till staten. Carried interest kan beskattas i inkomstslaget kapital, inkomstslaget tjänst eller enligt 57 kap. IL. Dock har det seda