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Inpatient withdrawal treatment (detoxification) is common in opioid dependence, although dropout against medical advice often limits its outcome. This study aimed to assess baseline predictors of dropout from inpatient opioid detoxification with buprenorphine, including age, gender, current substance use, and type of postdetoxification planning. A retrospective hospital chart review was carried ou

To meet and work with teenagers may be a challenge for caregivers as adolescence is a period when youths try to establish autonomy. Although asthma is an increasing problem worldwide, few studies have addressed professional caregivers' motives and actions. Therefore, the aim of this study was to describe professional caregivers' strategies in their work with teenagers with asthma. Grounded theory,

Many microRNAs (miRNAs) are known to be cell-type specific and are implicated in development of diseases. We investigated the global expression pattern of miRNAs in human pancreatic islets compared to liver and skeletal muscle, using bead-based technology and quantitative RT-PCR. In addition to the known islet-specific miR-375, we also found enrichment of miR-127-3p, miR-184, miR-195 and miR-493∗

Gymnasie- och universitetsutbildning var länge en elitens domän. Med ekonomisk tillväxt och ökande teknisk komplexitet växte dock behovet av specialiserad kunskap och färdigheter. Inför och under industrialiseringen tog systemen för högre utbildning emot ett ökande antal studenter och breddades med ett växande utbud av kurser och typer av utbildningsinstitutioner.Danmark, Norge och Sverige utgör rHigh school and university-level education was long an elite pursuit. However, with economic growth and rising technical complexity, the need for specialised knowledge and skills increased. In the run-up to and during industrialisation, higher education systems admitted a growing number of students and diversified across an increasing range of courses and types of educational institutions.Denmark,

The COVID-19 pandemic put a lot of strain on healthcare organizations. Nurses accountfor over 50% of healthcare staff, and how nurses perform in their work is influenced by a number ofhuman and work environmental factors. However, to our knowledge, there has not been a previousstudy with the intention to look at all areas that affect a sustainable working life and how theseimpact nurses’ mental we

The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg2+ across cellular membranes, importing the cation to mitochondria in eukaryotes. Yet, the conducting and regulation mechanisms of permeation remain elusive, particularly for the eukaryotic Mrs2 members. Here, we report closed and open Mrs2 cryo-electron microscopy structures, accompanied by functional characterization. M

This chapter presents the long-term clinical outcomes and prognosis of COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a global pandemic infecting over 773 million people and causing over seven million deaths worldwide as of December 2023 (WHO Coronavirus). Despite the United Nations proclaimed the coronavirus disease 19 (COVID-19) pandemic officially over on M

Gastroparesis, characterized by delayed gastric emptying without mechanical obstruction, is a recognized complication of long-standing diabetes. Its pathophysiology involves, amongst other mechanisms, autonomic dysfunction due to vagal nerve damage, impaired smooth muscle contractility, and hormonal dysregulation of intestinal motility. During Ramadan, fasting causes significant dietary changes du

The concept of ‘sustainable welfare’ conceptualizes welfare and wellbeing within planetary limits. Yet there is a lack of knowledge about possible social and political carriers of corresponding social-ecological transformations. For the promotion of the changes of societal core institutions that climate scientists deem necessary in the nearer future knowledge of which parts of the population are m

Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference a

A supercritical fluid extraction methodology was used to extract flavoring and bioactive compounds from truffles. Some parameters such as CO2 flow rate (1–3 mg/mL), extraction time (15–90 min) and different trapping food matrices (grape seed oil, gelatin, agar agar and water) were optimized using response surface methodology to enhance extraction and trapping yields. The optimal conditions (2.27 m

This article focuses on explaining management control under post-new public management (NPM). Drawing on the lessons from a case study, the article aims to advance the discussion of what post-NPM, as a new governance innovation, is and what problems practitioners encounter when they try to engage in post-NPM–oriented governance. The study reports the transformation of both management and control a

Current local or regional flood risk assessments, as required by the EU flood risk directive, rarely account for cascading effects due to interdependencies between critical infrastructures. However, it is essential to consider these effects, as they may severely impact areas outside the immediate flood risk area. The main purpose is to present and problematize a method (AB-CEM) for mapping and ana