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As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme. Here, we show that PDE3B is activated in response to high glucose, insulin and cAMP elevation in rat pancreatic islets and INS-1 (832/13) cells. Activation

Socially the context of archaeology is supposed to have travelled from kings, princes and aristocracy down to the bourgeoisie and the middle class. However members of the royal family still have a central role as it is seen from the current exhibition “Queen Margrethe II and archaeology” on Moesgård Museum at Århus and the National Museum in Copenhagen. The aim is here to examine the royal archaeo

Extended abstract Recent studies point at significant and ongoing technology induced changes in the retail landscape, creating new and interesting research avenues, new managerial challenges and a need to rethink existing business models (e.g., Burt and Sparks 2003; Kollmann et al., 2012; Sorescu et al., 2011). This paper aims at contributing to the literature concerning the managerial aspects th

It is widely accepted that firms in peripheral regions benefit to a lesser extent from local knowledge spillovers than firms located in agglomerations or industrial clusters. This paper investigates the extent to which innovative firms in peripheral regions compensate for the lack of access to local knowledge spillovers by collaborating at other geographical scales. So far the literature predomina

The new European Commission took office on 1 November 2014, with a number of structural changes including the creation of a First Vice-President, a responsibility given to the former Dutch Foreign Minister Frans Timmermans. The First Vice-President will ensure that every Commission proposal respects the principles of subsidiarity and proportionality. If the Commission pays more attention to the pr

Load problems in electricity markets occur both on the supply and demand side and can have technical, economic and even political causes. Commonly, such problems have been solved by expanding production and/or distribution capacity, importing electricity or by load management. Load management is a techno-economic measure for harmonizing the relations between supply and demand sides, optimizing pow

This book provides the reader with a broad policy analysis of a main set of tools aimed at realising an increasingly appreciated aspect of late modern democracy: green political consumerism. The authors illustrate and explain how green labels and other eco-standards are created and negotiated within a broad continuum between science and politics, by addressing political, regulatory, discursive, an