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You whistle – and ask, am I alone in here?A whistle emanates from the gut, proceeding to circulate beyond the body, as an absent presence that is felt rather than seen. Whistling in the dark — a nonchalant gesture set within an anxious environment; to summon your courage in the face of projected danger.In the Netherlands, we find ourselves placed at a critical juncture. Much has been said on the r

According to Lefebvre, modern capitalism has led to the commodification of urban life. Even though commodification has taken multiple distinct forms across the urban fabric, it could be argued that no urban feature is more representative of the proliferation of exchange values than shopping malls. Despite being privately owned and managed, commercialised and highly securitised, shopping malls have

T-1-family conotoxins belong to the T-superfamily and are composed of 10-17 amino acids. They share a common cysteine framework and disulfide connectivity and exhibit unusual posttranslational modifications, such as tryptophan bromination, glutamic acid carboxylation, and threonine glycosylation. We have isolated and characterized a novel peptide, Mo1274, containing 11 amino acids, that shows the

Växter behöver ljus för att växa. Ljuset omvandlas till kemisk energi genom fotosyntes i växtens blad. Den kemiska energin kan sedan användas av växten. Ljusabsorptionen i växter har en begränsning. Alltför mycket ljus kommer att orsaka bildning av högenergimolekyler som är skadliga för växterna. Därför måste växter justera mängden ljus som tas upp. Ljuset i miljön förändras ständigt och exponerin

BACKGROUND: Bacterial surfaces are complex systems, constructed from membranes, peptidoglycan and, importantly, proteins. The proteins play crucial roles as critical regulators of how the bacterium interacts with and survive in its environment. A full catalog of the motifs in protein families and their relative conservation grade is a prerequisite to target the protein-protein interaction that bac

Background: Cardiac allograft vasculopathy (CAV) is characterized by diffuse thickening of the arterial intima. Statins reduce the incidence of CAV, but despite the use of statins, CAV remains one of the leading causes of long-term death after heart transplant. Inhibitors of proprotein convertase subtilisin-kexin type 9 (PCSK9) substantially reduce cholesterol levels but have not been tested in he

Purpose: This study aimsed to provide a comprehensive description of the phenotypic and genotypic spectrum of SNAP25 developmental and epileptic encephalopathy (SNAP25-DEE) by reviewing newly identified and previously reported individuals. Methods: Individuals harboring heterozygous missense or loss-of-function variants in SNAP25 were assembled through collaboration with international colleagues,

Purpose: To describe the phenotype and genotype in a young woman with Danon disease. Methods: The patient underwent an ophthalmic examination including best corrected visual acuity (BCVA), fundus photography and fundus autofluorescence (FAF), full-field electroretinography (full-field ERG), multifocal ERG, optical coherence tomography (OCT) and SAP-Humphrey 30–2 at the ages of 20 and 25. Electrooc

This paper discusses the existence and scope of the morality exception from patentability, in Article 53 (a) of the European Patent Convention. The analysis will look into the history of the provision, debate its rational and interpretation by reference to three examples of technology areas: stem cell research; gene editing and AI/big data analytics.Bioscience innovation has always generated heate