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Objectives: Atrial fibrillation has been associated with increased mortality in the general population and mixed populations of critical ill. Atrial fibrillation can also affect patients during post-cardiac arrest care. We sought to assess the prognostic implications of atrial fibrillation following out-of-hospital cardiac arrest, including relation to the level of targeted temperature management.

The program system MOLCAS is a package for calculations of electronic and structural properties of molecular systems in gas, liquid, or solid phase. It contains a number of modern quantum chemical methods for studies of the electronic structure in ground and excited electronic states. A macromolecular environment can be modeled by a combination of quantum chemistry and molecular mechanics. It is f

Climate change and human activities threaten the availability and quality of fresh water resources globally, especially in less developed countries, where poverty and natural disaster risks are present. Despite important research efforts, gaps still exist regarding the understanding of the spatial-temporal variations of water quality and the movement of organic matter within tropical mountain lake

Timely detection and surveillance of disease community spread is a potent tool for implementing effective public health interventions. This study investigates the National Telehealth Service (1177 helpline) across 18 regions in Sweden in 2020 to identify early signals of community transmission of COVID-19 at the beginning of the pandemic. Focusing on calls related to key COVID-19 symptoms (cough,

Background: Neuroimaging with magnetic resonance imaging (MRI) may assist clinicians in evaluating brain injury and optimising care in comatose adults resuscitated after out-of-hospital cardiac arrest (OHCA). However, contemporary international data on its use are lacking. Aim: The primary aim was to compare the patient characteristics, early postresuscitation care, and neurological outcomes of pa

Background:Preparing for the end of life is believed to help mitigate emotional suffering for both patients and their caregivers. However, empirical evidence on the emotional benefits of feeling prepared for death remains limited.Aim:This study uses data from the international iLIVE project to examine how perceived end-of-life preparedness is associated with emotional suffering among patients and

Since most models used to study neuronal dysfunction display disadvantages and ethical concerns, a fast and reproducible in vitro model to study mitochondria-related neurodegeneration is required. Here, we optimized and characterized a 3-day retinoic acid-based protocol to differentiate the SH-SY5Y cell line into a neuronal-like phenotype and investigated alterations in mitochondrial physiology an

With Euro50 as a convenient telescope laboratory, the Euro50 team has continued development aiming at a European extremely large telescope (ELT). Here, we give a progress report. The needs of science and instrumentation are briefly discussed as is the importance of photometric stability and precision. Results are reported from work on integrated modelling. Details are given concerning point-spread

The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL patients and correlated the results with established CLL prognostic factors, time to treatment and over

Several psychiatric disorders may be characterized by peripheral telomere shortening. However, it is unclear whether telomere shortening is associated with these psychiatric disorders per se or, rather, with underlying dimensional parameters that are often, but not necessarily, associated with them. We explored the association between dimensional psychopathological measures and telomere length (TL

BACKGROUND: In contrast with macroorganisms, that show well-documented biogeographical patterns in distribution associated with local adaptation of physiology, behavior and life history, strong biogeographical patterns have not been found for microorganisms, raising questions about what determines their biogeography. Thus far, large-scale biogeographical studies have focused on free-living microbe

Some leading science programs undertaken with Very Large Telescopes and challenges driving the progress of the Extremely Large Telescopes are discussed together with the corresponding requirements. They concern expolanets, Earth-like planets, habitable zones, formation of stars and galaxies, first stars and cosmology. A description is attempted

In this work a compact fluorosensor has been built for point-monitoring and imaging applications. The instrument has been applied in fluorescence studies on green vegetation and on malignant tissue. The instrument is based on a violet diode laser, an integrated spectrometer and optical fibers for light delivery and collection of the fluorescence signal. This combination makes the system very compa

Preclinical studies support an anticancer effect of statin drugs, yet epidemiologic evidence remains inconsistent regarding their role in breast cancer primary prevention. Here, we report an updated analysis of the association between statin use and breast cancer incidence in the Nurses' Health Study (NHS) cohort. Postmenopausal NHS participants without a cancer history were followed from 2000 unt

OBJECTIVE: Increased inflammation and oxidative stress have been shown in Major Depressive Disorder (MDD), although there is significant heterogeneity across studies. Whether markers of inflammation and oxidative stress are associated with antidepressant treatment response in MDD is currently unclear. The goals of the present study are to investigate markers of inflammation and oxidative stress in

BACKGROUND: The study was carried out to evaluate the expression of major histocompatibility complex (MHC) molecules in retinal transplants with different tissue integrity.METHODS: Twelve adult rabbits received an allogeneic subretinal neuroretinal transplant, in the form of either fragmented embryonic cells or a complete full-thickness embryonic retina. A controlled transvitreal approach was used

År 2001 deklarerade den tanzaniska regeringen den första Primary Education Development Plan och därmed avskaffades den tidigare obligatoriska skolavgiften för grundskolan. I och med avskaffandet av skolavgiften förväntades andelen barn i grundskola att öka. Syftet med avhandlingen är att förstå hur reformen och dess fokus på avskaffandet av skolavgiften har påverkat föräldrars och vårdnadshavares In 2001, the first Primary Education Development Plan declared that the previous obligatory primary education fee was to be abolished in Tanzania. This was an attempt to increase the access to public primary education for all children. This thesis aims to understand how the reform and its focus on the abolition of school fee influences parents’ and caregivers’ support for primary education and imp