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Identification of intrinsic regulators in normal and malignant human hematopoiesis. An RNA-interference approach.

Bildandet av blodceller, hematopoesen, utgår från ett litet antal av de så kallade hematopoetiska stamceller som sitter i vår benmärg. Dessa celler har förmågan att ge upphov till alla mogna blodcellstyper av de tre hematopoetiska linjerna, samtidigt som de genom celldelning bibehåller sin egna mängd. Det har uppskattats att vi endast har några tusen hematopoetiska stamceller, men trots deras rela

Higher levels of the soluble receptor for advanced glycation end products and lower levels of the extracellular newly identified receptor for advanced glycation end products were associated with lipid-lowering drugs in patients with type 1 diabetes : a comparative cross-sectional study

Background: The receptors for advanced glycation end products (RAGE) are increased in atherosclerotic plaques. Soluble (s)RAGE decreases, whereas the extracellular newly identified receptor for advanced glycation end products (EN-RAGE) increases inflammatory responses mediated by RAGE. The aims were to explore whether sRAGE, EN-RAGE and the EN-RAGE/sRAGE ratio, were associated with the use of lipi

Vibration Attenuation for Satellite Reaction Wheels through the use of Field-Oriented Control

Complex space components are getting more important as the request for high precision space missions is increasing. The main contribution to vibrations on a satellite is the reaction wheels, the primary actuator in the attitude control of the satellite. One of the main sources of vibrations is torque ripple which is caused by various reasons, one being the control algorithm. This thesis focuses on

The materiality of encyclopedic information : Remediating a loved one – Mourning Britannica

Abstract in UndeterminedThis paper presents a qualitative thematic analysis of reader comments posted in connection to a series of articles published after Encyclopaedia Britannica’s announcement to forego its print edition. It shows how ideas of what information is, are entangled with ideas of what a certain medium is and does. Two research questions guide the analysis: 1) How are encyclopedias a

Creative Writing as a Communicative Act : An Artistic Method

With Habermas' theory of communicative action as the starting point, a theoretical model is devised to investigate the act of creative writing as formulated in interviews made with students and teachers on a university study program me in creative writing. This article explores writers' work procedures in a communicative network of institutional and everyday practices, in the light of established

Effects of nitrogen deposition on the growth, metabolism and activity of ectomycorrhizal fungi

Popular Abstract in Swedish Nästan alla träd i våra skogar lever i samspel (symbios) med svampar. Många av dessa är ”vanliga” svampar, sådana som vi är vana vid att se och plocka i naturen, (exempelvis soppar, kremlor, riskor, flugsvampar och kantareller) men det finns också de som inte bildar fruktkroppar, eller har fruktkroppar som vi inte ser. Fruktkropparna, de som kan hamna i svampkorgen, är Elevated nitrogen (N) deposition is an environmental problem that can affect plants and microorganisms, which are vital for the terrestrial N and carbon (C) cycles. This thesis has investigated the response of ectomycorrhizal fungi (EMF) to increased N deposition. Ectomycorrhizal fungi form mutualistic interactions with the roots of woody plants, including almost all boreal and temperate forests

Two-dimensional acoustic focusing of microparticles in two-phase droplet-based microfluidic systems increases particle detectability

We have fabricated a silicon-glass two-phase droplet-based microfluidic system and implemented two-dimensional acoustic focusing prior to droplet generation as well as continuously throughout the whole system to increase particle detectability. Using acoustic focusing we have effectively minimized sedimentation of the encapsulated particles and thereby increased particle detectability by as much a

Acoustophoretic manipulation of sub-micron objects enabled by density gradients

Direct and precise manipulation of sub-micron particles such as bacteria, platelets, organelles, microvesicles, exosomes or virus particles is challenging. We describe for the first time how acoustic streaming in the bulk can be efficiently reduced by introducing a density or compressibility gradient and that this enables focusing of 500-nm-diameter particles in a standard acoustophoresis channel.

Evaluation of a fiber-optic fluorescence spectroscopy system to assist neurosurgical tumor resections

The highly malignant brain tumor, glioblastoma multiforme, is difficult to totally resect without aid due to its infiltrative way of growing and its morphological similarities to surrounding functioning brain under direct vision in the operating field. The need for an inexpensive and robust real-time visualizing system for resection guiding in neurosurgery has been formulated by research groups al

A new path towards accountability? an Analysis of the IIIM for Syria

Konflikten i den Syriska Arabiska Republiken började för mer än tio år sedan och ingen lösning är i sikte. Konflikten anses vara den mest dokumenterade konflikten någonsin. Trots att konflikten har pågått under en lång tid saknas det straffrättsligt ansvar för de begångna brotten. Det har gjorts försök, att genom användandet av international straffrätt hänvisa konflikten till den Internationella BThe conflict in the Syrian Arab Republic is ongoing since more than ten years, and there is no end in sight. The conflict is deemed to be the most documented conflict of all time. Despite the longevity of the conflict, there has been a lack of criminal accountability for the crimes committed. The international community has through the use of international criminal law attempted to refer the confl