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The aim of this thesis is to examine the relationship between writing and alterity in three recent novels written by J. M. G. Le Clézio, Désert (1980), Onitsha (1991) and La quarantaine (1995), which deal with the encounter between the so-called primitive cultures and Western society. The first chapter contains a more general discussion on the discourse of alterity in literature and the French exo

PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease.

Next-generation sequencing experiments have shown that microRNAs (miRNAs) are expressed in many different isoforms (isomiRs), whose biological relevance is often unclear. We found that mature miR-21, the most widely researched miRNA because of its importance in human disease, is produced in two prevalent isomiR forms that differ by 1 nt at their 3' end, and moreover that the 3' end of miR-21 is po

European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study: rationale, design and population characteristics

The European Prospective Investigation into Cancer and Nutrition (EPIC), which covers a large cohort of half a million men and women from 23 European centres in 10 Western European countries, was designed to study the relationship between diet and the risk of chronic diseases, particularly cancer. Information on usual individual dietary intake was assessed using different validated dietary assessm

Genetic probes of three theories of maternal adjustment: II. Genetic and environmental influences

This is the first report of the Twin Mom Study, an investigation. of three hypotheses concerning influences on maternal adjustment. These hypotheses concern the role of the marital and parent-child relationships in mediating genetic influences on maternal adjustment and on the importance of the mothers' marital partners as a specifiable source of influences on their adjustment not shared with thei

Object-Oriented Declarative Program Analysis

This thesis deals with techniques for raising the programming level for a particular kind of computations, namely those on abstract syntax trees. Such computations are central in many program analysis tools, such as compilers, smart language-sensitive editors, and static analysis tools. All techniques presented in this thesis support modular description and efficiency and are capable of handling l

Mitochondrial DNA sequence evolution and phylogeny of the Atlantic Alcidae, including the extinct great auk (Pinguinus impennis)

The Atlantic auk assemblage includes four extant species, razorbill (Alca torda), dovekie (Alle alle), common murre (Uria aalge), and thick-billed murre (U. lomvia), and one recently extinct species, the flightless great auk (Pinguinus impennis). To determine the phylogenetic relationships among the species, a contiguous 4.2-kb region of the mitochondrial genome from the extant species was amplifi

Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system.

Retinoic acid (RA) is an important morphogen that regulates many biological processes, including the development of the central nervous system (CNS). Its synthesis from vitamin A (retinol) occurs in two steps, with the second reaction - catalyzed by retinal dehydrogenases (RALDHs) - long considered to be crucial for tissue-specific RA production in the embryo. We have recently identified the Xenop

Marsupial Mitogenomics

Popular Abstract in Swedish Marsupialia (pungdjur) delas in i 280 nu levande arter, som är uppdelade i 19 familjer och sju ordningar. Släktskapet mellan de sju ordningarna har studerats på molekylär nivå på grundval av mitokondriella genom som sekvenserats i sin helhet. Pungdjur, jämte placentala (moderkaks-) däggdjur och kloakdjur, utgör de nu levande representanterna för klassen däggdjur. PungdjThe relationships of the mammalian infraclass Marsupialia have been investigated by phylogenetic analysis using completely sequenced mitochondrial genomes. The organisation and structure of the marsupial mitochondrial genomes deviates from the general mammalian structure. Several features, not known from other mammalian mitochondrial genomes have been shown to be present in all seven living marsup

Fatal colonic ischaemia: A population-based study.

Objectives. To estimate the incidence of fatal colonic ischaemia (CI) and the cause-specific mortality of CI, and to describe the localization and extension of colonic infarction and quantify the risk factors associated with CI. Material and methods. Between 1970 and 1982 the autopsy rate in Malmo, Sweden, was 87%, creating the possibilities for a population-based study. Out of 23,446 clinical aut

Perceptual defensiveness and ESP performance: Reconstructed DMT ratings and psychological correlates in the first German DMT-ESP experiment

The concept of perceptual defensiveness is related to subliminal perception and preconscious processing. Meta-analyses of earlier experiments, 6 in the United States and Holland and 10 in Iceland, on the Defense Mechanism Test (DMT)-ESP relationship had shown significantly higher ESP scoring by less defensive participants. In the present experiment, conducted in Freiburg, Germany, 50 participants

Bioproduction of (Z,E)-9,12-tetradecadienyl acetate (ZETA), the major pheromone component of Plodia, Ephestia, and Spodoptera species in yeast

BACKGROUND: (Z,E)-9,12-tetradecadienyl acetate (ZETA, Z9,E12-14:OAc) is a major sex pheromone component for many stored-product moth species. This pheromone is used worldwide for mating disruption, detection, monitoring, and mass trapping in raw and processed food storage facilities. In this study, we demonstrate the biological production of ZETA pheromone by engineered yeast Saccharomyces cerevis

Dynamic spatio‐temporal flow modeling with raster DEMs

A user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. MoA user-friendly high-resolution intermediate complexity dynamic and spatially distributed flow model is crucial in urban flood modeling. Planners and consultants need to improve the accuracy of floods and estimation of risks. A new flow model will serve as a rapid tool to improve identification of these. This article provides a detailed explanation of a model based on a multiple flow algorithm. Mo

Software Quality Assurance - Concepts and Misconceptions

Software quality engineering is concerned with building software products with required quality and assessing the level of quality. Software processes are important assets in achieving and assessing the software quality. Furthermore the adherence to defined processes is a key issue to having the software engineering under control and to enable process improvement. The software quality assurance (S

Supporting Change Impact Analysis Using a Recommendation System: An Industrial Case Study in a Safety-Critical Context

Change Impact Analysis (CIA) during software evolution of safety-critical systems is a labor-intensive task. Several authors have proposed tool support for CIA, but very few tools were evaluated in industry. We present a case study on ImpRec, a recommendation System for Software Engineering (RSSE), tailored for CIA at a process automation company. ImpRec builds on assisted tracing, using informati

A Generalized Zero-Forcing Precoder with Successive Dirty-Paper Coding in MISO Broadcast Channels

In this paper, we consider precoder designs for multiuser multiple-input-single-output (MISO) broadcasting channels. Instead of using a traditional linear zero-forcing (ZF) precoder, we propose a generalized ZF (GZF) precoder in conjunction with successive dirty-paper coding (DPC) for datatransmissions, namely, the GZF-DP precoder, where the suffix ‘DP’ stands for ‘dirty-paper’. The GZF-DP precode

A study on Electron Beam Melted Ti-6Al-4V

The work presented in this dissertation is concerned with the microstructures and surface roughness of test slabs of Ti-6Al-4V produced by one of powder based Additive Manufacturing (AM) technique namely electron beam melting (EBM). The effects of process parameters of a EBM system and geometry factors of a EBM build such as slabs’ thickness and height etc. on the microstructure and the surface ro

Membrane process opportunities and challenges in the bioethanol industry

Due to increasing oil price and environmental concerns, current European initiatives are aiming to increase the share of Biofuel used for transportation from approx. 2 % (2005) to 5.75% in 2010. The production capacity of bioethanol in Germany alone has therefore to increase during this period from 0.7 mio. m³ to 1.8 mio. m³ 1. The feed stocks of current bioethanol concepts are sugar and starch

Spatiotemporal coupling of attosecond pulses

Attosecond pulses in the extreme ultraviolet (XUV) spectral range are today routinely generated via high-order harmonic generation (HHG), when intense ultrashort laser pulses are focused into a gaseous generation medium. The effect is most easily understood in a semi-classical picture [1]. An electron can tunnel ionize from the distorted atomic potential, pick up kinetic energy in the laser field,