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Splicing in cancer Proteins are functional molecules responsible for every biochemical process that sustain living organisms. However, how genetic information is expanded to generate amazing diversity of proteins during development and in cancer remains still mostly unresolved. The mechanism we have to account for this diversity is known as splicing. Information-containing RNA molecules, copies
Problemformulering: Vilka åtgärder kan vidtas för att bemöta de utvecklingsbehov Miljöbyggnad står inför gällande betygssystemets och ingående indikatorers utformning? Syfte: Syftet är att i första hand utvärdera betygssättningssystemet i Miljöbyggnad. I andra hand ska förbättrande åtgärder utarbetas och provas. Arbetet ska avse vara en del i underlaget inför utvecklingen av systemet. SlutsatserThe Issue/problem: What measures can be taken to address the development needs Miljöbyggnad are facing regarding its rating system and detailed design of indicators? The Purpose: The purpose is primarily to evaluate the rating system in Miljöbyggnad. Secondly, improvement measures will be developed and tested. The work will relate to being part of the basis for the development of the system. The
I en allt mer energieffektiv värld så spelar allt fler av energiförlusterna allt större roll. Tidigare hade man samma förluster som idag från kanalsystemet men de totala förlusterna var större. När man nu har minskat andra förluster i huset får kanalför- lusterna en allt större betydelse i den totala energianvändningen, vilket leder till att det nu finns anledning att ta större hänsyn till dem. I To minimize energy losses becomes more and more important in a world where energy efficiency is a big priority and necessary if we want a future on our planet. The relative impact from ducting losses on the energy performance of the building was earlier so small that it was plausible to ignore them. Nowadays many of the other parts of the losses have been cut which means the air ducts now might st
Cracks in concrete compromise structural integrity by exposing steel reinforcement to corrosion agents, shortening its service life. Fungal-induced calcium carbonate (CaCO3) precipitation via urea hydrolysis offers a fast and robust self-healing mechanism to seal the cracks, extending the lifespan while reducing the carbon (C) footprint of concrete infrastructure. However, current studies rely on
Objectives: It has been well established that male erectile dysfunction is frequently associated with vascular diseases. The normal function of cavernous arteries is considered a prerequisite to maintain sufficient blood flow to the trabecular spaces in order to enable penile erection. Contractility of cavernous arteries is regulated by the peripheral autonomic nervous system and endogenous factor
The main objective of Task 23 Small Scale Reformers for On-site Hydrogen Supply has been to provide a basis for harmonization of technology for on-site hydrogen production from hydrocarbon s– fossil and renewable. The four sub-objectives were to: • Develop a basis for harmonized capacities for the on-site hydrogen reformer unit • Identify and examine issues related to the promotion of widespread u
Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c
Background: The purpose of this study is to validate a new five-tiered prognostic classification system to better discriminate cancer-specific mortality in men diagnosed with primary non-metastatic prostate cancer. Methods: We applied a recently described five-strata model, the Cambridge Prognostic Groups (CPGs 1-5), in two international cohorts and tested prognostic performance against the curren
As a result of the huge economic and industrial development that human has been experiencing for decades or centuries, there are millions of potentially contaminated sites around the globe. Potentially contaminated sites are those which industrial, agricultural, mining and waste containment activities with potential to contaminate soil and groundwater has taken place in. A small number of these co
Popular Abstract in Swedish Avhandlingen kretsar kring centralbankens möjligheter att kontrollera inflationstakten. Under senare tid har mycket forskning ägnats åt att analysera och utvärdera de institutionella förutsättningarna för centralbanker, såväl avseende graden av oberoende som vilka mål penningpolitiken bör inriktas mot; exempelvis direkta inflationsmål versus användandet av indirekta målAfter an introductory chapter, the hypothesis is made in chapter two: that central bank power to control the rate of inflation rests on the bank’s ability to achieve a role as a focal point for inflation. Inflation is a measure of changes in the general price level, the price level is an index of individual prices, and to predict future price levels is thus to predict future prices on individual i
It is generally maintained that learning should be a part of the daily routines of many organizations; this is often referred to as lesson learned processes. The purpose of organizational learning is to foster improvements that seek to both reduce incidents and accidents and reduce their consequences when they nevertheless happen. Safety work is widespread among many organizations, e.g. aviation,
Popular Abstract in Swedish I avhandlingen Det förbjudna mödraskapet argumenterar jag för att surrogatmödraskap bör tillåtas också i Sverige. Idag är metoden förbjuden. Ett av de bärande argumenten är att en legalisering skulle kunna bidra till att bryta ner flera konservativa föreställningar som idag finns kring kvinnors roll i reproduktonen.Surrogate motherhood, or surrogacy, means that a woman carries a child with the explicit intention not to keep the child after the birth. This reproductive method is illegal according to Swedish legislation. The question at heart of the dissertation is the following: Can a legal prohibition of surrogacy be morally justified? My answer is simple no. Consequently, I work with the thesis that there a
In the domain of current spatial semiotics two important, but also radically different, approaches can be distinguished as modelling the co-operative agency of human, material and legal properties of space, namely that of Manar Hammad’s and that of Bruno Latour’s. Hammad, being a semiotician, more true to the Greimasian heritage, regards a finite set of principal actantial types (owners, visitors,
Drøbak Montessori lower secondary school is Norway’s first plus-energy school and also the first school built after the Norwegian Powerhouse-concept, www.powerhouse.no. This concept implies that the building shall produce more renewable energy during the lifetime of the building, than used for materials, production, operation, renovation and demolition. To achieve the energy ambitions for the proj
In recent decades, obesity has gone from being a problem of first world countries to a global one. It is considered one of the main risk factors for many serious medical conditions. In order to treat and/or prevent obesity different strategies have been considered, one of the most common being the inhibition of lipase, the enzyme that is mainly responsible for lipid digestion. Even though there is
The built environment is important to achieve a sustainable society. From a sustainability perspective, refurbishment can be preferable to building anew. A significant proportion of the built environment needs to be refurbished. Refurbishment projects also provide the opportunity to proactively upgrade the working environment for users during operation and use.Research concerning the working envir
Carpets have been important motives in the visual arts since the Renaissance (Holbein, Lotto, Vermeer), and they were especially made prominent through 19th century Orientalism (Delacroix, Gérôme, Cézanne). The influence on painters and writers was thorough and the carpet, now more than just a motive, became a model and instrument for images. This tendency was termed the “carpet paradigm” by Josep
Biorefining of lignocellulosic biomass into biofuels and chemicals can help replace fossil resources and decrease anthropogenic greenhouse gas emissions. This thesis is focused on the effects of mixing on the enzymatic hydrolysis of pretreated biomass. Two different types of biomass were studied: softwood (Norway spruce and Scots pine), and the energy grass giant reed. Before enzymatic hydrolysis,
Security lighting plays a vital role for safe evacuation during an emergency such as power outage or a fire related incidence. Installing a security lighting system properly is more crucial for a horse riding facility for two reasons. Firstly, if a sports activity is ongoing at the exact moment of an emergency, the activity needs to be ended safely with the help of security lights to avoid injurie
The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. It was Huxley’s firm belief that mankind needed a unifying system of thought that could motivate action and change. Transhumanism was also an attempt to unite a more traditional humanistic view of the human as containing some form of core essence The evolutionary biologist Julian Huxley (1887–1975) attempted to promote a “religion for the future,” which he would come to refer to as Transhumanism. It was Huxley’s firm belief that mankind needed a unifying system of thought that could motivate action and change. Transhumanism was also an attempt to unite a more traditional humanistic view of the human as containing some form of core essence
