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Background: There is mounting evidence supporting the role of the microbiota in hypertension from experimental studies and population-based studies. We aimed to investigate the relationship between specific characteristics of the gut microbiome and 24-h ambulatory blood pressure measurements. Methods: The association of gut microbial species and microbial functions, determined by shotgun metagenom

To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respective

Cooperativity is an efficient way for nature to regulate complex processes, allowing for control over a narrower range of concentrations compared to noncooperative phenomena. Here, we investigate the cooperative binding of α-Synuclein to lipid membranes under different conditions, aiming to uncover the underlying molecular driving forces. We interrogate the role of electrostatic interactions by ra

Objective: To investigate cellular immune responses to the herpes zoster (HZ) subunit (HZ/su) vaccine in patients with rheumatoid arthritis (RA) treated with Janus kinase inhibitors (JAKis). Methods: RA patients treated with JAKi (n=46) at the Department of Rheumatology, Skåne University Hospital, Sweden, and healthy controls (n=37) received two doses of the HZ/su vaccine. Blood samples were colle

Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B. We further identifie

Objective: To investigate whether baseline use of pain medication is associated with program adherence during a three-month digital treatment program for individuals with hip or knee osteoarthritis (OA). Design: An observational cohort study using registry data on weekly participant adherence from 33078 participants enrolled in a digital education and exercise therapy program. Poor adherence was d

OBJECTIVE: Diabetes significantly increases the risk for atherosclerotic complications, including coronary artery disease (CAD). Previous studies have suggested that adult-onset diabetes can be classified into five different clinical subtypes, including moderate obesity-related diabetes (MOD). The aim of this study was to investigate the genetic associations between the five diabetes subtypes and

Animals align their body in relation to different environmental cues, including spontaneous directional responses relative to the geomagnetic field known as magnetic body alignment. The biological significance of this behavior, however, remains undetermined for most taxa. In previous studies, migratory songbirds aligned their body with the cardinal directions of the geomagnetic field and their mig

Skin wounds remain a clinical challenge, especially for burns and chronic wounds, and existing therapies seldom re-engage the rapid, scar-sparing repair programs observed in nature. Planarians are super-regenerators capable of rebuilding the entire organism from small fragments, and their extracellular vesicles might encode potent prorepair cues. But whether planarian-derived extracellular vesicle

The focus of this study was to evaluate the feasibility of incorporating Perlin noise, a method that has previously been used to model the tissue distribution of software breast phantoms, when creating a ‘compressible’ software breast phantom used in finite element analysis. Several compressible phantoms were created to represent different stages of aging in a virtual patient when younger, fibrogl

The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain specific or more broadly protective. Here, we quantified the opsonic-antibody response following invasive S. pyogenes infection. Four patients with S. pyogenes bacteremia between 2018 and 2020 at Skåne Uni

The MM500 meta-study aims to establish a knowledge basis of the tumor proteome to serve as a complement to genome and transcriptome studies. Somatic mutations and their effect on the transcriptome have been extensively characterized in melanoma. However, the effects of these genetic changes on the proteomic landscape and the impact on cellular processes in melanoma remain poorly understood. In thi

BACKGROUND: Five classic thrombophilias have been recognized: factor V Leiden (rs6025), the prothrombin G20210A variant (rs1799963), and protein C, protein S, and antithrombin deficiencies. This study aimed to determine the thrombotic risk of classic thrombophilias in a cohort of middle-aged and older adults. METHODS AND RESULTS: Factor V Leiden, prothrombin G20210A and protein-coding variants in

We compared vaccine effectiveness (VE) against severe COVID-19 during calendar periods from December 2021 to March 2022 when Omicron BA.1 and BA.2, respectively, were the dominating virus variants in Scania county, Sweden. We used continuous density case-control sampling matched for sex and age, and with further adjustment for differences in comorbidities and prior infection. VE remained relativel

The plasma–surface interface has sparked interest due to its potential of creating alternative reaction pathways not available in typical gas–surface reactions. Currently, there are a limited number of in situ studies investigating the plasma–surface interface, restricting the development of its application. Here, we report the use of in situ ambient pressure X-ray photoelectron spectroscopy in ta

MILJÖVETENSKAP Preliminärt schema ht 2020 Kurs: Grundkurs i Miljövetenskap MVEA01, HT2020 Kursansvarig: Katarina Hedlund Lokaler: Meddelas senare. Undervisningen kommer att ske både online och i universitetets lokaler. Litteratur: Kursbok: Environment- The Science behind the Stories, 5e upplagan,, global edition Withgott, Laposata, Förlag-Pearsons, ISBN 9781292063317. Motsvarande läroböcker i Milj

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/kopia_av_schema_mvea01_2020_enl_fhm_direktiv.pdf - 2026-05-20

Schema_miljöskydd20_200819 AMW.xlsx 1 MILJÖSKYDD MVET10 Preliminärt schema 200819 Kurs: MVET10 Miljöskydd Kursansvarig: Högni Hansson Lärare: BN=Birgitta Nordquist, KD=Katrin Dierschke, LEH=Lars-Erik Harderup, MD=Mats Dahlblom, KA=Karin Adalberth, JL=Jonathan Loivre, LS=Lars Siljebratt, Sara Edlund Fredholm, TF=Thomas Ferdinansson, SD=Sara Danielson, TH=Torbjörn Håkansson, LL=Lovisa Lundgren, IB=I

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_miljoskydd20_200819_amw.pdf - 2026-05-20

Schema_miljöskydd20_20200622.xlsx 1 MILJÖSKYDD MVET10 Preliminärt schema 200831 Kurs: MVET10 Miljöskydd Kursansvarig: Högni Hansson Lärare: BN=Birgitta Nordquist, KD=Katrin Dierschke, LEH=Lars-Erik Harderup, MD=Mats Dahlblom, KA=Karin Adalberth, JL=Jonathan Loivre, LS=Lars Siljebratt, Sara Edlund Fredholm, TF=Thomas Ferdinansson, SD=Sara Danielson, TH=Torbjörn Håkansson, LL=Lovisa Lundgren, IB=Ing

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_miljoskydd20_20200622.pdf - 2026-05-20