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Background: It remains unclear whether heritable factors can contribute to risk stratification for ischemic stroke in patients with atrial fibrillation (AF). We examined whether having a sibling with ischemic stroke was associated with increased risk of ischemic stroke and mortality in patients with AF. Methods and Results: In this nationwide study of the Swedish population, patients with AF and t

In the ActivAbles and STARR projects we are developing interactive training tools for stroke survivors. Our initial user studies pointed to balance being a key ability, therefore one of the developed tools is an interactive balance pad. Equipment exists for persons with good balance (eg. Wii), but most consumer games and exercises are less suited for many stroke survivors. The development process

Importance: High gluten intake during childhood may confer risk of celiac disease. Objectives: To investigate if the amount of gluten intake is associated with celiac disease autoimmunity and celiac disease in genetically at-risk children. Design, Setting, and Participants: The participants in The Environmental Determinants of Diabetes in the Young (TEDDY), a prospective observational birth cohort

We investigated the impact on work life exits from reduced access to disability pension (2006), and financial incentives to extend working life. Method and materialWe used labour statistics of all employees in Sweden, Social insurance and income data, to compare occupational groups (SSYK, based on ISCO-88), and blue and white collar workers, with regard to i) lost years in working life due to deat

The use of interactive visualization techniques in Digital Humanities research can be a useful addition when traditional automated machine learning techniques face difficulties, as is often the case with the exploration of large volumes of dynamic—and in many cases, noisy and conflicting—textual data from social media. Recently, the field of stance analysis has been moving from a predominantly bin

The purpose of this study is to investigate the prediction of Ki-67 expression of breast cancers using MRI parameters from ultrafast (UF) DCE-MRI, DWI, T2WI, and the lesion size. Breast MRI was performed with a 3T scanner using dedicated breast coils. UF DCE-MRI was obtained using Compressed Sensing-VIBE (prototype sequence). As a kinetic parameter of UF DCE-MRI, maximum slope (MS) was defined as

Using electronic health records data and machine learning to guide future decisions needs to address challenges, including 1) long/short-term dependencies and 2) interactions between diseases and interventions. Bidirectional transformers have effectively addressed the first challenge. Here we tackled the latter challenge by masking one source (e.g., ICD10 codes) and training the transformer to pre

Neutrophils have been classically viewed as a homogenous population. Recently, neutrophils were phenotypically classified into pro-inflammatory N1 and anti-inflammatory N2 sub-populations, but the functional differences between the two subtypes are not completely understood. We aimed to investigate the phenotypic and functional differences between N1 and N2 neutrophils, and to identify the potenti

Background: All-cause and AIDS-mortality in Europe has been decreasing between 1996 and 2020. However, regional differences as well as their drivers remain unclear. This study investigates mortality differences and their drivers, including usage of and response to antiretroviral therapy (ART) and active tuberculosis (TB), among people with HIV across Europe. Methods: People with HIV enrolled in Eu

Purpose: The purpose of this study was to investigate whether the lesion risk score provided by an AI system is influenced by the selection of exposure parameters. Methods: A breast phantom which contains a lesion, was imaged with digital mammography with different imaging conditions. The tube voltage, the dose level and the anode-filter combination were varied based on an exposure obtained with a

Popular Abstract in Swedish Synd och skam. Ogifta mödrar på svensk landsbygd, 1680-1880. Avhandlingens utgångspunkt har varit ogifta mödrar på svensk landsbygd i ett långtidsperspektiv, 1680-1880. Arbetet är kvinnohistoriskt och utgår från en önskan att synliggöra betydelsen av kön i det äldre samhället. Hur tänkte och resonerade man kring kön och sexualitet i det förindustriella bondesamhället? The situation of unmarried mothers in Swedish rural society during 1680–1880 is the subject of this thesis. It focuses on the judicial and religious discourse concerning extra-marital sexuality. The state felt duty-bound to control extra-marital sexuality, and this resulted in a dynamic legislative arena. An important objective has been to study the local consequences of legislative changes and ex

The early career professionals in the field of Cardiovascular Magnetic Resonance (CMR) face unique challenges and hurdles while establishing their careers in the field. The Society for Cardiovascular Magnetic Resonance (SCMR) has expanded the role of the early career section within the society to foster the careers of future CMR leaders. This paper aims to describe the obstacles and available oppo

Healthcare organizations are under increasing pressure to account for their performance to outside constituencies. This chapter reviews the background, nature, and consequences of organized efforts to enhance transparency in healthcare. The driving forces differ between regions, but the trends are broad enough to result in similar developments across Europe. Market reforms and quality concerns cre

Following the idea originally proposed during the ESO-Workshop The Very Large Telescope in 2030, the concept of a high resolution spectrograph for the VLT has been further explored, both for the science and technological aspects. Such an instrument will fill a gap in capabilities amongst the landscape of future instrumentation planned for the next decade. Its key characteristic will be high spectr

Advanced cancer, with its considerable physical symptoms and psychosocial burdens, represents an existential threat and major stressor to patients and their caregivers. In response to such stress, patients and their caregivers use a variety of strategies to manage the disease and related symptoms, such as problem-focused, emotion-focused, meaning-focused, and spiritual/religious coping. The use of

Background: Quantitative magnetic resonance imaging (MRI), e.g. relaxation parameter mapping, may be sensitive to structural and compositional tissue changes, and could potentially be used to non-invasively detect and monitor early meniscus degeneration related to knee osteoarthritis. Objective: To investigate MR relaxation times as potential biomarkers for meniscus degeneration through comparison

Climate change will have a progressively increasing impact on environmental degradation and environmentally dependent socio-economic systems with potential to cause substantial population displacement. The key concerns in Less Developed Countries (LDCs) will include serious threats to food security and health, considerable economic decline, inundation of coastal areas, and degradation of land and

Addressing the housing needs of the displaced communities is an essential part of a recovery programme that has distinct links to livelihoods, health, education, security and social and family stability. The housing factor acts as a social centre for family and friends, a source of pride and cultural identity and a resource that commands both political and economic importance. Therefore, addressin

Popular Abstract in Swedish Traditionellt har effekten av behandling inom kärlkirurgi främst utvärderats med objektiva mått, som till exempel beräkning av ankelindex och gångsträcka. Dessa data ger värdefull information men de återger inte hur patientens klarar sitt dagliga liv eller hur behandling återverkar på deras livskvalitet. Detta styrks i tidigare forskning som visar att korrelationen mellThe aim of this thesis was to assess quality of life in patients with varying degrees of lower limb ischaemia before and after revascularisation, to assess quality of life in relation to the degree of ischaemia and the respondents’ sense of coherence (SOC) and in comparison with a healthy control group, and to compare two different quality of life instruments regarding their usefulness as outcome