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The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to
In recent years, subsets of chronic lymphocytic leukemia (CLL) patients carrying quasi-identical or stereotyped B cell receptors (BcRs) have been identified that share clinicobiological features and disease outcome. While these stereotyped subsets show distinct gene expression and genomic profiles, the DNA methylation landscape remains largely unexplored. By applying high-resolution 450K methylati
Recent advancements in catchment hydrology (such as understanding catchment similarity, accessing new data sources, and refining methods for parameter constraints) make it possible to apply catchment models for ungauged basins over large domains. Here we present a cutting-edge case study applying catchment-modelling techniques with evaluation against river flow at the global scale for the first ti
Spectral induced polarization is a well-established geophysical method that can be measured in both time- and frequency domain. Time- and frequency domain methods are theoretically equivalent via the Fourier transform. However, data acquisition parameters such as the sampling frequency and pulse length affect the actual spectral content of real time domain waveforms. Comparative studies showing th
OBJECTIVE: To explore whether a prime-boost vaccination strategy, i.e., a dose of pneumococcal conjugate vaccine (PCV) and a dose of 23-valent polysaccharide vaccine (PPV23), enhances antibody response compared to single PCV dose in patients with inflammatory rheumatic diseases treated with different immunosuppressive drugs and controls. METHODS: Patients receiving rituximab (n = 30), abatacept (n
BACKGROUND: Heavy drinking (HD) and binge drinking (BD) exhibit marked differences in their relationships with contextual-level factors imbedded in geographical areas of residence. The objective is to identify sociodemographic factors, both at the individual and at the contextual level, associated with these 2 main hazardous consumption patterns.METHODS: Cross-sectional study using data from the 2
The accession to the European Union was based on the financial gains that could be made on the single market. When acceding the Union the Member States gave up parts of their state sovereignty. This statement is not unproblematic. My thesis touches on the posting of workers. Since the adoption of the new Enforcement Directive on the Posting of Workers Directive, two reports on the Swedish impleme
Sweden faces an upcoming period where thousands of buildings built during the million program period will be in need of a façade renovation. There is a large energy-saving potential in these buildings, since they are often poorly insulated and often have a ventilation system without heat recovery. Performing energy-efficient renovation measures to a building are expensive, which results in that th
Stimulation of innovation is a hot topic around the world. The developed economies are nowadays significantly dependent on innovation for further growth. One central source of innovation is universities and their ability to turn new knowledge into value-adding innovations. One of these technology transfer measures is through the creation of university spinoffs (USOs). High-tech startups, however,
Background: Maternal mortality is still a key issue in public health. Postpartum haemorrhage (PPH) is one of the main direct causes of maternal mortality in many countries around the world, including Kyrgyzstan where approximately half of all maternal deaths are due to this complication. Maternal mortality caused by PPH can be prevented through cost-effective interventions including active managem
PV power production is becoming more and more common and one can easily imagine that a so called boom is near in southern Sweden. As the distribution grids are designed for power flow out to the households, and not the other way around, the question is what will happen that sunny day when the households in a neighborhood produce more electricity than they consume. This master thesis project was ca
Denna uppsats utreder hur finansiella produkter klassificeras i inkomstslaget kapital, och vilka skatterättsliga skillnader som finns mellan de olika kategorierna i inkomstslaget. Utifrån praxis och inkomstskattelagens systematik redogörs för hur en avyttring av kryptovalutan Bitcoin ska klassificeras och beskattas. Gällande rätt analyseras sedan mot bakgrund av principen om likformighet och skattThis paper examines how financial products are classified within the capital gains bracket and which tax differences follow from such classification. Based on practice and the methodology of the Income tax act, the paper describes how a divestment of the cryptocurrency Bitcoin should be classified and taxed. The result is thereafter analyzed from the perspective of the principle of uniformity and
The goal of this thesis work is to implement a convolutional neural network on an FPGA device with the capability of recognising human sign language. The set of gestures that the neural network can identify has been taken from the Swedish sign language, and it consists of the signs used for representing the letters of the Swedish alphabet (a.k.a. fingerspelling). The motivation driving this projec
Devices connected to an Internet-based network, known as the Internet of Things (IoT), are becoming more common both privately in the household or on businesses. Everything from the lighting to coffee makers and washing machines, to the cars in the garage and the door locks can now be equipped with sensors and connected via the Internet to an application by users. Combitech has developed an Intern
Abstract Introduction: Smoking is a major public health concern, accounting for nearly 700,000 deaths on an annual basis, globally. The socio-economic differences within smoking are well established, reflected in a social gradient that is estimated to account for half of the socio- economic differences in mortality for men aged 35-69 years in developed settings, such as the European region. Aim:
Aktieägaravtal har stor inverkan på det praktiska företagslivet. Aktieägare kan här på ett hemligt och flexibelt sätt skräddarsy begränsningar för hur aktierna ska kunna överlåtas. För minoritetens del handlar det ofta om att stärka sin ställning gentemot röststarka aktieägare. Ofta föreskrivs det överlåtelsebindningar i aktieägaravtal som begränsar aktiernas överlåtbarhet i syfte att förhindra oöShareholders’ agreements have a major impact on the practical business life. Here, shareholders can in a clandestine and flexible way make tailor-made restrictions on how and when the shares can be transferred to third parties. As for the minority, entering a shareholders’ agreement is often about strengthening its position towards shareholders holding stronger voting power. More often than not, S
En gärningsperson som begår ett brott under påverkan av en allvarlig psykisk störning och även vid domstillfället lider av en sådan störning, ska i första hand dömas till rättspsykiatrisk vård istället för fängelse. Vid misstanke om att en allvarlig psykisk störning föreligger får gärningspersonen genomgå en rättspsykiatrisk undersökning. Undersökningen resulterar i att de sakkunniga läkarna och pA perpetrator who commits a crime affected of a severe mental disorder, and also by the time for the verdict is affected by such a disorder, shall primarily be sentenced to care instead of prison. If a severe mental disorder is suspected to be present, the perpetrator may undergo a forensic psychiatric examination. The examination results in a report of expertise, where the doctors and psychiatris
Digital technologies and their significance to society have caused their existence and impact to be referred to as entailing a digital revolution. For businesses, digitalization is the use of digital technologies to create new business models and value-adding activities. The use of digital technologies can in turn result in possible improvements in several areas e.g., productivity. The possible ou
En social och ekologisk hållbar trafikplanering innebär inte enbart att utveckla hållbara färdmedel, utan även att optimera alla typer av färdmedel för att minimera dess miljöpåverkan. I dagens samhälle utvecklas ständigt nya åtgärder som främjar den hållbara trafikplaneringen. En nyutvecklad teknik, så kallad fordonsdata återfinns i ett urval nyare bilmärken, där RSI (Road Surface Information) ärSustainable traffic planning means to not only developing sustainable means of conveyance, but also to optimize all types of means of transport to minimize their environmental impact. New and innovative ideas are constantly being developed where the measures are to promote sustainable traffic planning. Two newly developed technologies vehicle data and RSI (Road Surface Information) are used in a s
Granular Activated Carbon (GAC) is nowadays suggested as a fourth (quaternary) treatment step at municipal wastewater treatment plants to remove certain chemicals and particularly organic micropollutants (OMPs). This work investigated the different factors that affect the performance of the GAC filter for the removal of micropollutants in a municipal wastewater treatment plant. This study is purel
