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Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. Those with PRKN mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of tau. Yet all three mutation types are i

Purpose: The sugar industry is always pressured to be suitable and enhance its operational effectiveness. Digital Twin (DT) has the potential to transform this industry. However, the lack of industry-specific Key Performance Indicator (KPI) frameworks makes it challenging to implement them. This study provides a hierarchical KPI model for DT adoption in the sugar sector, interconnecting the United

BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predispose to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.METHODS: This

BackgroundWorkplace sexual harassment remains a persistent issue in Sweden. Research about organisational antecedents has been criticised for being limited in scope, possibly overlooking contextual factors relevant for the occurrence of sexual harassment. This study examined two factors capturing aspects of organisational climate, perceived relational justice and authoritarian treatment, and their

Therapeutic proteins are essential in modern medicine but are often susceptible to chemical degradation during production, transportation, and storage, which can compromise functionality and even lead to immunogenicity in patients. This study investigates how the structure of the affibody GA-Z affects its chemical stability and how glycerol stabilizes the protein against deamidation and isomerizat

Reasonably correct phylogenies are fundamental to the testing of evolutionary hypotheses. Here, we present phylogenetic findings based on analyses of 67 complete mammalian mitochondrial (mt) genomes. The analyses, irrespective of whether they were performed at the amino acid (aa) level or on nucleotides (nt) of first and second codon positions, placed Erinaceomorpha (hedgehogs and their kin) as th

Objectives: In this study, we investigated whether polymorphisms of the HIF-1 alpha gene may account for the patterns of HIF-1 alpha protein expression in non-small cell lung carcinomas (NSCLC) and the expression of HIF-1 alpha down-stream proteins. Methods: Specific HIF-1 alpha polymorphisms were assessed in a series of patients with NSCLC: (a) the C to T transition at nucleotide 1744 (position 2

Supernumerary ring chromosomes (SRC) account for approximately 10% of prenatal marker chromosomes and 60% of these SRCs are associated with an abnormal phenotype of the patient carrying them. SRCs have, with few exceptions, not been characterized at the molecular genetic level. Here, we present the first case of a SRC 12 thoroughly investigated with tiling resolution array-based comparative genomi

Background: Sleep disturbance is common in intensive care patients. Aside from its unpleasantness, there is a correlation with intensive care unit (ICU) syndrome/delirium. Reasons for sleep deprivation appear to be multifactorial, including the underlying illness, an acute superimposed disturbance, medications, and the ICU environment itself. There are reasons to believe that alterations of the 'b

Gas phase reactions at elevated temperatures are versatile tools for material manufacturing and energy conversion. They are of great commercial interest, but they often entail hazardous impacts on the environment. There is consequently a pronounced need for the further develpment of processes utilising these types of reactions. Spectroscopic methods, especially when combined with lasers, are idea

The extremely small feature size and total sample volume of semiconductor nanowire materials has meant that advanced techniques have been required for even the most routine sample characterization since the structures were first reported. Electron microscopy has been the technique of choice for fast and reliable determination of nanowire morphology, structure, and composition since the earliest re

Aim: To study the influence of specific factors and events during pregnancy and the perinatal period on the risk of children developing inflammatory bowel disease. Methods: Population-based national register study. Linkage between the Swedish Medical Birth Register and the Swedish Hospital Discharge Register during the period 1987 to 2000 identified 455 singleton infants who later developed inflam

Knee kinematics after anterior cruciate ligament (ACL) reconstruction is of interest in studies evaluating the effect of training programs. Many studies have addressed knee flexion/extension but not valgus/varus movements. Considering that joint stability is a major concern in ACL reconstruction surgery, movements occurring in the frontal plane of the knee also deserve attention. Knee extensor tor

Nondisplaced or minimally displaced femoral neck fractures are commonly treated with internal fixation, because of its less invasive and less time-consuming nature, as well its retention of the biological properties of the hip. Internal fixation with screws or pins is the current clinical routine in Sweden. However, the authors of some recent studies in elderly patients have suggested that the use

”All min strävan under denna skoldag – som ett jordeliv utgör – har varit att så mycket som möjligt främja det mänskliga broderskapets förverkligande på vår lilla jord.”Med dessa ord sammanfattade Nelly Thüring (1875–1972) sin livsfilosofi när hon vid 94 års ålder blev intervjuad av Socialdemokratiska kvinnoförbundets tidskrift Morgonbris. Som resetalare hade hon varit med och byggt upp det nystar”All I have strived for during this school day – that an earthly life amounts to – has been to do my utmost to promote the realization of human brotherhood on our little Earth.”This is how Nelly Thüring (1875–1972), at the age of 94, summarized her philosophy of life in an interview with Morgonbris, a journal published by the Swedish Social Democratic Women’s Federation. During the 1920s, she had

Mount Fuji, the iconic mountain of Japan, remains a young and frequently active volcano. However, despite these dangers, people have continuously lived in the landscapes surrounding Mount Fuji since the peopling of the Japanese Archipelago, approximately 38ka. In this paper we explore the geological history of Mount Fuji and use a landscape archaeology approach to reconstruct how Jomon communities

For researchers studying wildlife distributions of the past, the assignment of faunal depictions and remains to species can often present considerable challenges. Regrettably, many studies do not systematically consider all options and sources of evidence and, as a result, questionable identifications are widespread in the literature, which compromises the trustworthiness of meta-analyses of human

In this study, we investigated the prevalence of mental disorders and the use of psychopharmacologic drugs among individuals with cerebral palsy (CP). We studied how the association between CP and mental illness develops over the life course (between ages 5 and 65 years), and how it varies across disability specific factors (intellectual disability, gross motor function and communicative ability).

Generating electricity from solar photovoltaics (PVs) has massive potential, but realising this potential will require a genuine understanding of transaction costs associated with the adopters' acquisition of the technology. The objective of this study is thus to empirically assess the transaction costs that solar PV adopters carry when proceeding with an acquisition process. Data on transaction c

BACKGROUND: Preventing infection in primary sutured perineal tears after childbirth is crucial to avoid systemic antibiotic use and potential complications from poor healing. This study aimed to investigate the efficacy of an antibacterial, triclosan-coated suture (VicrylPlus ®) in reducing infection in primary sutured childbirth-related perineal tears. METHODS: The PLUS study was a single-center,