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Background: Life skills-based approaches are broadly used in HIV prevention programmes world-wide. However, evaluations of such programmes have found mixed evidence for their effects on indicators of safer sexual behaviour. Methods: Questionnaires of 4,381 participants of the Star for Life (SFL) life skills-based prevention programme in South African schools were analysed using binary logistic reg

Läkemedelstransportering med lipidnanopartiklar (LNP), särskilt svampfas lipidnanopartiklar, har varit intressanta på grund av dess möjlighet att inkapsla läkemedel och överföra läkemedlet genom cellmembranet. Svampfas LNP formuleringen kan påverkas av lipidens molekylära struktur, temperaturen, pH-värdet, utspädningen, bufferten och existerandet av en stabilisator. Projektets syfte var att ersättDrug delivery with lipid nanoparticles, especially sponge phase lipid nanoparticles (LNP), has been well studied because of its ability for drug encapsulation and transferring the drug through the cell membrane. The sponge phase LNP formulation could be affected by the molecular structure of the lipid, the temperature, pH, dilution, the buffer, and the addition of a stabiliser. This project aimed

The European Union implements the Environmental Noise Directive (END), which offers a framework for evaluating and assessing environmental noise. All EU members are required to create strategic noise maps to inform the public about noise pollution and its effects. This study followed these directives and guidelines to collect the required data and employed the NORD2000 model to simulate traffic no

- Kan man förutse en kräms hållbarhetstid utifrån dess tjocklek? I detta examensarbete har de reologiska- och texturegenskaper undersökts hos två typer av krämer, en med Cetostearylalkohol som förtjockare, och en med ett mer naturligare alternativ som Xanthan Gum, samtidigt som stabiliteten hos dessa två krämer har undersökts under längre tidsperiod. Att utveckla nya läkemedel är en tidskrävandeThe aim of this project was to develop analytical methods for characterizing rheological behavior of creams. The rheological methods of shear ramp, thixotropy, amplitude sweep, and frequency sweep, as well as texture analysis were initially developed at LTH and later transferred to Galenica. For this project two series of emulsions were formulated and used as test subjects for these methods. One u

Histopathological examination, crucial in diagnosing diseases such as cancer, traditionally relies on time- and resource-consuming, poorly standardized chemical staining for tissue visualization. This thesis presents a novel digital alternative using generative neural networks and a point light source (PLS) microscope to transform unstained skin tissue images into their stained counterparts. This

As CO2 builds up in the atmosphere causing global climate change (IPCC, 2022) trees have become an international symbol of combatting this, and for good reason. Trees take up CO2 which as a result combats these changes, and when these trees are cut down fewer individuals remain to take up the CO2 that we humans emit (Chapin et al., 2011). This means that clear-cut areas don’t act as the carbon sin

High-order harmonic generation (HHG) is a highly nonlinear optical process in which extreme ultraviolet (XUV) radiation is generated due to the interaction of an intense laser field with atoms. This process enables the production of high harmonics, which would not be achieved with standard nonlinear media. The utilization of two-color laser fields (formed by combining a fundamental field with one

Skogsskador och skogsdöd är ett växande problem i Europa. "Svarta Triangeln", som ligger i bergsområdet där Tysklands, Tjeckiens och Polens gränser möts, är en av de värst drabbade områdena. I dagsläget saknas kunskap för att kunna förklara skogsskadorna helt och hållet, men markförsurningen i området, som orsakas främst av förbränning av svavelrikt kol i de många kolkraftverken, är trolForest decline is an increasing problem in Europe. "The Black Triangle" area, situated in the mountainous region where the borders of Germany, the Czech Republic and Poland meet, is one of the worst damaged areas. The reasons for the forest dieback are not fully understood, but the soil acidification caused by the burning of sulphur rich coal in the region is considered a major cause. To

Den fotokemiska reaktorn vid Copenhagen Centre for Atmospheric Research, Köpenhamns universitet, har i denna studie används för att bestämma nya värden på hastighetskonstanterna k(i) för reaktionen: CH3Br + OH -> produkter (i) och k(ii) för reaktionen: CH3Br + O(1D) -> produkter. (ii) Radikalerna (O(1D) och OH) framställdes i studien genom att fotolysera ozonmolekyler med UV-C-ljus. OxidationsprocThe photochemical reactor in Copenhagen Centre for Atmospheric Research, University of Copenhagen, was used to determine new values for the rate constants k(i) and of the reaction: CH3Br + OH −> products (i) and k(ii) for the reaction: CH3Br + O(1D) −> products. (ii) The radicals (O(1D) and OH) were produced by photolysis of ozone molecules with UV-C light. The oxidation process was monitored by a

Populärvetenskaplig sammanfattning: De kvartära landskapsformerna i södra Sverige skapades till stor del under och i samband med avsmältningen av den senaste inlandesisen. Skåne blev isfritt för ca 13 000 år sedan med en isavsmältning i nordvästar Skåne mot NO. I samband med denna avsmältning skapades ett småkuperat moränlandskap, plana slätter, mindre kullar och åsar. Åsarna har bildats av materiThe purpose with this study is to identify and examine heterogeneities within the ground, which is important for the groundwater flow on a more local scale. Investigation of the geology within an area is normally done through observations in field, combined with studies of geological maps and documented drillings. Depending on drilling methods, varying results are obtained but often with a good re

Under vissa typer av operationer, till exempel då kärlen kring hjärtat opereras, använder sig läkare av en speciell typ av röntgenmaskin för att orientera sig inuti kroppen, så kallad genomlysning. För att undgå att öppna upp bröstkorgen på patienten går läkarna in med små verktyg i kärlen via ljumskarna och upp till hjärtat. Eftersom läkarna står så nära patienten träffar en del av strålningen de

Nynas Petroleum is one of the world´s largest producers of naphthenic specialty oils. They have refineries in several parts of the world and their largest production facility is situated in Nynäshamn, Sweden. They also have oil depots in all continents and their largest depot is located in Antwerp, Belgium. In the beginning of 2007 Nynas introduced a new type of transformer oils, called Nova grade

BACKGROUND: Cerebrospinal fluid (CSF) clearance via the olfactory pathway is well-documented in animal models. However, results from in vivo human studies appear inconsistent. Studies using intrathecal (IT) Gadolinium-based contrast agents (GBCA) enhanced MRI showed minimal tracer pass-through from intracranial to extracranial olfactory regions such as the nasal mucosa. Conversely, human imaging s

Importance: General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They involve risks for patients, but to estimate these, more data are needed. Objective: To develop a more precise overview of the rate at which

Introduction: Prenatal exposure to inflammatory states has been suggested to influence offspring neurodevelopment. The aim was to investigate if offspring exposure to maternal Inflammatory bowel disorder (IBD), or specifically the IBD disorder Crohn's disease, during gestation is associated with neurodevelopmental or psychiatric disorders in childhood. Material and Methods: We conducted a populati

BACKGROUND: Prognostic stratification is essential for guiding treatment and follow-up in cutaneous melanoma. Previous international studies suggest that patients with localized stage IIB and IIC melanoma have poorer survival rates than those with lymph node involvement in stage IIIA. Nevertheless, Swedish guidelines still recommend less frequent follow-up for stage II than for stage III melanoma

Plast är ett av våra vanligaste material i vardagen. Som helhet är det ett billigt, slitstarkt och lätt material. Det finns olika typer av plast med olika egenskaper. Gemensamt för alla plaster är dock att de består av (oftast en typ av) molekyler som sitter ihop i långa, repeterande kedjor. Dessa kedjor kallas polymerer. När plast slängs i naturen eller hanteras fel som avfall finns det en risk aAs plastic pollution in aquatic environments persists, gaining a deeper understanding of nanoparticles has become increasingly important. Yet, the question remains: what happens to plastic as it breaks down into smaller components, and ultimately, what end products are formed? Current plastic degradation methods are limited in their environmental applicability and efficiency. This study aims to pr

ImportanceThe management of complications following oral cavity squamous cell carcinoma (OCSCC) surgery can be challenging. Previous studies show conflicting results on complication risks after preoperative radiotherapy (RT), necessitating a randomized controlled trial (RCT).ObjectiveTo compare early complications during hospitalization for OCSCC surgery between patients receiving preoperative acc

Background: Obstetrical anal sphincter injuries are complications of vaginal birth that have the potential to cause substantial maternal morbidity. Predicting these injuries might help to improve maternal care as well as antenatal counseling and patient education. Previous attempts to create prediction models have in many cases involved variables only known postpartum, which limits their use in an

INTRODUCTION: There are few recent studies on trends over time in functional outcome and mortality after stroke, with results separately presented for ischaemic stroke (IS) or ICH. We aimed to determine temporal changes in functional outcome and case-fatality 90 days after IS and ICH in Sweden between 2010 and 2019. PATIENTS AND METHODS: We included patients (≥18 years) with first-ever IS or ICH r