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Solar mean magnetic field (SMMF) measurements from the Wilcox SolarObservatory and with SOHO/MDI are analyzed using continuous wavelettransforms, SMMF variability is found at a number of temporal scales.Detected SMMF variations with a 1-2 year period is considered to belinked to long-term variations in the internal rotation of the Sun.Intermediate SMMF oscillations with a period of 80-200 days are
För att vara patenterbar, måste varje uppfinning uppvisa ”utility” (användbarhet), som det kallas i USA, eller ”industrial application” (industriell tillämpbarhet), som det heter i Europa. Utöver ”nyhet”, ”uppfinningshöjd”, och kravet på en ”tillräcklig beskrivning av uppfinningen” i patentansökan utgör denna förutsättning både i USA och i Europa ett av de fyra grundläggande patenterbarhetskriteri
OBJECTIVE: We have evaluated a new technique of cardiac de-airing that is aimed at a) minimizing air from entering into the pulmonary veins by opening both pleurae and allowing lungs to collapse and b) flushing out residual air from the lungs by staged cardiac filling and lung ventilation. These air emboli are usually trapped in the pulmonary veins and may lead to ventricular dysfunction, life-thr
The authors present in this paper how the extended Mie theory can be used to translate not only end-point data but also temporal variations of extinction peak-position changes, peak(t), into absolute mass uptake, (t), upon biomacromolecule binding to localized surface plasmon resonance (SPR) active nanoparticles (NPs). The theoretical analysis is applied on a novel sensor template composed of a th
Interfacial electron transfer is one of the key processes in the novel type of photovoltaic cells-dye sensitized solar cells (DSSC). By means of transient absorption spectroscopy we have studied the dynamics of the initial photo-induced processes in dye-sensitized nano-porous thin films of wide-band gap semiconductor microcrystallines, which represent the main photoactive part of DSSC. In the most
Inflammatory leiomyosarcoma (ILMS), defined as “a malignant neoplasm showing smooth muscle differentiation, a prominent inflammatory infiltrate, and near-haploidization”, is a very rare soft tissue tumor with a generally favorable prognosis. The morphologic features of “histiocyte-rich rhabdomyoblastic tumor” (HRRMT) are similar to those of ILMS, although this lesion shows by definition a skeletal
In vehicular communications systems the channel estimation filter suppresses the additive noise in channel estimates obtained from pilot symbols. Vehicular channels show local stationarity for a finite region in time and frequency, only. Such a process can be divided into consecutive stationarity regions, allowing to calculate a Wiener filter. We analyze the increase of the mean square error (MSE)
Non-responders to checkpoint inhibitors generally have low tumor T cell infiltration and could benefit from immunotherapy that activates dendritic cells, with priming of tumor-reactive T cells as a result. Such therapies may be augmented by providing tumor antigen in the form of cancer vaccines. Our aim was to study the effects of mitazalimab (ADC-1013; JNJ-64457107), a human anti-CD40 agonist IgG
Although CD8+ T cell tolerance to tissue-specific antigen (TSA) is essential for host homeostasis, the mechanisms underlying peripheral cross-tolerance and whether they may differ between tissue sites remain to be fully elucidated. Here, we demonstrate that peripheral cross-tolerance to intestinal epithelial cell (IEC)–derived antigen involves the generation and suppressive function of FoxP3+CD8+
I discuss the dilution of responsibility of action and the idea of a symmetrical relationship between artefacts and humans. In doing so, I argue that meaning making is an activity unilaterally performed by agents, leading to an asymmetrical relationship between agents and artefacts. Therefore, the study of the one who is responsible for the action, the meaning-maker (with the capability to act) is
Background: Mohs micrographic surgery (MMS) is a precise, tissue-sparing surgical technique that offers superior cure rates compared to traditional surgical excision. However, the degree of difficulty of MMS depends on many variables, and consequently, the number of surgical stages required for each case is quite unpredictable.Objectives: To identify risk factors for complicated MMS, defined as MM
A frequency domain, weighted least squares, sensitivity function shaping procedure is presented. Pole placement is used as the basic servo design procedure. Controller overparametrization gives the degree of freedom for shaping the sensitivity function. A benchmark design example shows the capabilities of the method. The computation is simple making the design suitable for adaptive control.
CONTEXT: Vitamin D (Vit-D), parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23) are the major calciotropic hormones involved in the regulation of blood calcium levels from the intestine, kidney, and bone through a tight endocrine feedback loop system. Altered levels of calcium itself or through the effect of its regulatory hormones could affect blood pressure (BP), but the exact mec
Mesenchymal stromal cells (MSCs) were identified more than 50 years ago, and research advances have promoted the translation of pre-clinical studies into clinical settings in several diseases. However, we are only starting to uncover the local factors that regulate cell phenotype, cell function, and cell viability across tissues following administration in different diseases. Advances in pre-clini
The overall aim of this prospective study was to delineate the role of monocytic myeloid-derived suppressor cells (Mo-MDSCs) in patients with metastatic breast cancer (MBC). MDSCs are a heterogeneous group of immunosuppressive cells often enriched in different malignancies which hold prognostic and predictive value for clinical outcomes. Here, we assessed the clinical significance of Mo-MDSCs in 5
The problem of adversarial CNN attacks is considered, with an emphasis on attacks that are trivial to perform but difficult to defend. A framework for the study of such attacks is proposed, using real world object manipulations. Unlike most works in the past, this framework supports the design of attacks based on both small and large image perturbations, implemented by camera shake and pose variat
Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a specific loss of hypocretin-producing neurons. The incidence of NT1 increased in Sweden, Finland and Norway following Pandemrix®-vaccination, initiated to prevent the 2009 influenza pandemic. The pathogenesis of NT1 is poorly understood, and causal links to vaccination are yet to be clarified. The strong association with Human leukocy
Article 5 of the Council of Europe Convention on Preventing and Combating Violence against Women and Domestic Violence (the Istanbul Convention) enshrines the standard of due diligence to frame states’ obligations. In the existing literature in the area of violence against women, the standard of due diligence has been uncritically endorsed; the reason being that it has played a crucial role in the
Background: The members of the Task Force on Contact Dermatitis and the Task Force on Occupational Dermatoses of the European Academy of Dermatology and Venereology (EADV), of the European Dermatology Forum (EDF), and the members of the UEMS Section of Dermatology-Venereology (UEMS-EBDV) we want to vindicate the fundamental role that the specialist in Dermatology has in the diagnosis and managemen
