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BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)

Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined i

With an ever increasing need for assessment of neurophysiological activity in connection with injury and basic research, the demand for an efficient and reliable data acquisition system rises. Brain-machine interfaces is one class of such systems that targets the central nervous system. A necessary step in the development of a brain-machine interface is to design and implement a reliable and effic

We investigating the role of anticipation and attention in a dynamic environment in a number of large scale simulations of an agent that tries to negotiate a number of gates that continuously open and close. In particular we have looked at learning mechanisms that can predict the future positions of the gates and control strategies that will allow the agent to pass through the gates unharmed. The

The present dissertation delineates how the fairy tale character, Little Red Riding Hood, has appeared in different screen versions. It is a thematic and historical analysis of the development of film versions and other traces of the story 1901 to 2001, focussing particulary on the representation of Red Riding Hood herself. The story of this little girl, mostly dressed in different red garments, i

This article deals with the early development of the Jesus prayer in Early Christian monasticism of the 4th to the 7th century. It proceeds in two steps. First, a quite uniform matrix of practices and aims related to three early monastic authors (John Cassian, Diadochus of Photike, and John Climacus) is discerned. It is evident that the practice is not clearly defined in this period. It is also ap

The Sound Area, located between Sweden and Denmark, is one of the most intensely trafficked waters in the world with complex traffic patterns and a bridge/tunnel under construction, which will link the two countries. This high level of complexity increases the probability of both maritime accidents and very negative consequences of them. This paper presents the ergonomic part of an ongoing multidi

Popular Abstract in Swedish Denna avhandling är en studie av en grupp cypriska stenskulpturer som ställdes upp som votivgåvor i öns tempel och helgedomar under 500-talet f.Kr. Det som utmärker gruppen är att de bär cypriska versioner av karakteristisk egyptisk klädedräkt och smycken. För att kunna svara på frågor som varför denna egyptiserande votivtyp dedicerades på ön, varifrån impulserna kom ocThis thesis is a study of a particular limestone votive statuary type which was dedicated in the sanctuaries on Cyprus during the entire 6th century B.C. Common to the group of figures is that they are wearing a Cypriote version of an Egyptian-type outfit, including characteristic Egyptian royal headgear and jewelry. In order to be able to answer questions on the origin of the Egyptianizing iconog

The risk for type 1 diabetes is strongly associated with HLA-DQ and the appearance of beta cell autoantibodies against either insulin, glutamate decarboxylase (GAD65), insulinoma-associated protein-2 (IA-2), or zinc transporter 8 (ZnT8). Prolonged exposure to autoantibodies may be related to T cell exhaustion known to occur in chronic infections or autoimmune disorders. It was hypothesized that au

We initiate a proof complexity theoretic study of subsystems of cutting planes (CP) modelling proof search in conflict-driven pseudo-Boolean (PB) solvers. These algorithms combine restrictions such as that addition of constraints should always cancel a variable and/or that so-called saturation is used instead of division. It is known that on CNF inputs cutting planes with cancelling addition and s

Background: Namibia has made significant gains in the fight against malaria, with a target of elimination by 2023. We examined the genotype and allele frequencies of glucose-6-phosphate dehydrogenase (G6PD) deficiency to inform decisions on primaquine use, as we recently detected clusters of Plasmodium ovale curtisi in Kavango. Methods: A multistaged cross-sectional sampling method was used to enr

Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2–PRDM10 or a MED12–PRDM10 gene fusion. Preliminary data suggest that these so-called PRDM10-rearranged tumors (PRT) are clinically more indolent than classical high-grade UPS, and hence important to recognize. Here, we assessed the spectrum of accompanying mutations and

Background--Exposure to cadmium has been associated with carotid plaques, inflammation in carotid plaques, and increased risk of ischemic stroke. This study examined the separate and interacting effects of blood cadmium levels and carotid plaques on the risk of incident ischemic stroke. Methods and Results--Cadmium levels were measured in 4156 subjects (39.2% men; mean ± SD age 57.3 ± 5.9 years) w

Emerging technologies are paving the way for future revolutionary advances in science that may open the possibility to change the very anthropological definition of human being. This mere possibility has lead to ethical interrogations concerning the nature and boundaries of human nature and our relationship with science and technology. Meanwhile the Law has faced the challenge of reflecting on the

We examine the use of in-cylinder measurements for engine control, with emphasis on emissions control during cold start. First, the cold start emissions control problem is described. An overview of previous research in the area of in-cylinder measurements for control is presented, including sensors for pressure and other quantities. Next, analysis of cylinder pressure is described. Lastly, a cold-

The ESS linac will deliver an unprecedented 5 MW of average beam power when completed. Beyond the 90 MeV normal conducting front-end, the acceleration is performed using superconducting structures up to the design energy of 2 GeV. As the ESS will send the beam to a fixed tungsten target, the emittance is not as important a factor as in injectors. However, the losses have to be studied in detail, i

The ESS linac is currently under construction in Lund, Sweden, and once completed it will deliver an unprecedented 5 MW of average power. The ion source and LEBT commissioning starts in 2018 and will continue with the RFQ, MEBT and the frst DTL tank next year and up to the end of the fourth DTL tank in 2020. This paper will summarize the commissioning plans for the normal conducting linac with foc