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Introduction: For fast and effective antibiotic therapy of serious infections like sepsis, it is crucial with rapid information about antibiotic susceptibility, especially in a time when the number of infections caused by multi resistant bacteria has escalated in the world. Methods: Here, we have used a semi-quantitative MALDI-TOF-MS based method for antibiotic resistance detection, MBT-ASTRA™, wh

The paper studies the local solvability and subellipticity for square systems of principal type. These are the systems for which the principal symbol vanishes of first order on its kernel. For systems of principal type having constant characteristics, local solvability is equivalent to condition (Ψ) on the eigenvalues. This is a condition on the sign changes of the imaginary part along the oriente

This chapter presents three interviews with three influential voices in the field of social movement and civil society studies, namely, those of Doug McAdam, Jeffrey Alexander, and Nina Eliasoph. They all share their perspectives on social movements’ role in society’s moral development, the role of morality internally in social movements, and the role of morality for social science as a practice.

Ball-rolling dung beetles are known to integrate multiple cues in order to facilitate their straight-line orientation behaviour. Recent work has suggested that orientation cues are integrated according to a vector sum, that is, compass cues are represented by vectors and summed to give a combined orientation estimate. Further, cue weight (vector magnitude) appears to be set according to cue reliab

The agile methodology is gaining attention among practitioners and researchers in hardware development. As a new methodology, it is a source of misunderstandings and misinterpretations. This is problematic at the managers' levels as they may hinder its adoption or lead to its impractical implementation and use. This study, therefore, aims to explore the manager's level of understanding of the agil

Inflammasomes are large multiprotein complexes that assemble mainly in innate immune cells after detection of microbial or sterile insults. Activation of inflammasomes is a key proinflammatory event during infection, and many pathogens have evolved specific evasion mechanisms to evade or inhibit inflammasome activation. One such pathogen is the common bacterium group A Streptococcus (GAS), which c

It has been suggested that the occurrence rate of hot Jupiters (HJs) in open clusters might reach several per cent, significantly higher than that of the field (~a per cent). In a stellar cluster, when a planetary system scatters with a stellar binary, it may acquire a companion star, which may excite large-amplitude von Zeipel-Lidov-Kozai oscillations in the planet's orbital eccentricity, trigger

Object shift (OS) is a word order phenomenon in Scandinavian languages where under some circumstances the object appears before a sentential adverb. Despite the frequent assumptions that word order is determined in syntax, and despite the link of OS and syntactic phenomena like V2, there is no consensus that OS is a syntactic phenomenon. Particularly, it has been observed that OS targets specifica

Chronic glomerular and tubular nephrotoxicity has been reported in up to 50% and 25%, respectively, of children and adolescents treated with ifosfamide and up to 60% and 30% of those given cisplatin. Up to 35% of children have proteinuria and microalbuminuria, implying chronic glomerular damage, after unilateral nephrectomy for a renal tumour. We are still learning about nephrotoxicity due to the

Bdellovibrio and like organisms (BALOs) are obligate predatory bacteria that selectively prey on a broad range of Gram-negative bacteria, including multidrug-resistant human pathogens. Due to their unique lifestyle, they have been long recognized as a potential therapeutic and biocontrol agent. Research on BALOs has rapidly grown over the recent decade, resulting in many publications concerning mo

Does a teachable agent influence the uptake or neglect of ‘critical constructive feedback’ and learning within a digital environment? 285 middle-school students engaged with a history learning game in a 2x2 study design. One dimension was inclusion of a teachable agent. Orthogonal was whether critical constructive feedback was presented automatically or only when students chose. Analyses showed th

Context.-The diagnostic distinction of pulmonary neuroendocrine (NE) tumors from non-small cell lung carcinomas (NSCLCs) is clinically relevant for prognostication and treatment. Diagnosis is based on morphology and immunohistochemical staining. Objective.-To determine the diagnostic value of insulinoma-associated protein 1 (INSM1), in comparison with established NE markers, in pulmonary tumors. D

In 2010, Spence and Van Gelder presented a family of CNF formulas based on combinatorial block designs. They showed empirically that this construction yielded small instances that were orders of magnitude harder for state-of-the-art SAT solvers than other benchmarks of comparable size, but left open the problem of proving theoretical lower bounds. We establish that these formulas are exponentially

Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus. Combined with an unhindered spread of multi drug-resistant strains, this has triggered research into novel anti virulence (i.e. anti α-hemolysin) drugs. Their func

To date, few studies have investigated the simultaneous effects of macro-scale parameters (MSPs) such as land use, population density, geology, and erosion layers on micro-scale water quality variables (MSWQVs). This research focused on an evaluation of the relationship between MSPs and MSWQVs in the Siminehrood River Basin, Iran. In addition, we investigated the importance of water particle trave

Small cell lung cancer (SCLC) is characterized by rapid growth and high metastatic capacity. It has strong epidemiologic and biologic links to tobacco carcinogens. Although the majority of SCLCs exhibit neuroendocrine features, an important subset of tumors lacks these properties. Genomic profiling of SCLC reveals genetic instability, almost universal inactivation of the tumor suppressor genes TP5

Background and aims: Several different scoring systems for early risk stratification after out-of-hospital cardiac arrest have been developed, but few have been validated in large datasets. The aim of the present study was to compare the well-validated Out-of-hospital Cardiac Arrest (OHCA) and Cardiac Arrest Hospital Prognosis (CAHP)-scores to the less complex MIRACLE2- and Target Temperature Mana

To investigate aging effect on the passive film of Ni23Cr15Mo and Ni22Cr9Mo3Nb, synchrotron-based X-ray photoelectron spectroscopy (XPS) was used to analyze the structure and composition of the air-formed passive film on the alloys. The corrosion resistance of the two Ni alloys in 1 M NaCl solution was evaluated with electrochemical cyclic polarization measurement. The synchrotron XPS measurement

Production of fish meal and plant-based feed proteins continues to increase to meet the growing demand for seafood, leading to impacts on marine and terrestrial ecosystems. Microbial proteins such as single-cell proteins (SCPs) have been introduced as feed alternatives since they can replace current fish feed ingredients, e.g., soybean, which are associated with negative environmental impacts. Mic

BACKGROUND: Studies of obesity with or without metabolic aberrations, commonly termed metabolically unhealthy or healthy obesity, in relation to cancer risk are scarce.METHODS: We investigated body mass index (BMI, normal weight/overweight/obesity) jointly and in interaction with metabolic health status in relation to obesity-related cancer risk (n = 23,630) among 797,193 European individuals. A m