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The skin barrier is a responding membrane that separates environments with profoundly different water contents. This implies a substantial water gradient across the skin membrane, which controls transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as the activity of water in the outermost layer of skin. By applying an occluding film composed of a pharmaceutic
Current treatments that are efficient in controlling effector T cells responses to allografts have limited efficacy on the accelerated rejection mediated by memory T cells. Effective targeting of alloreactive memory T cells may therefore be explored to improve therapeutic approaches towards solving this problem. In this study, we investigated the synergistic effect of CD44/CD70 blockade and anti-C
Atypical hemolytic uremic syndrome has been associated with dysregulation of the alternative complement pathway. In this study, a novel heterozygous C3 mutation was identified in a factor B-binding region in exon 41, V1636A (4973 T > C). The mutation was found in three family members affected with late-onset atypical hemolytic uremic syndrome and symptoms of glomerulonephritis. All three patients
Popular Abstract in Swedish Cancer är ett samlingsnamn på sjukdomar som kännetecknas av okontrollerad celltillväxt. I friskt tillstånd växer kroppens celler kontrollerat. Cancertillståndet startar när någon av dessa celler förändras så att tillväxten ökar. När tillväxten ökar så tilltar också celldelningen. Om ingen åtgärd vidtas kommer cancern till slut att slå ut funktionen hos det organ som denCancer is the collective name for diseases that have one thing in common ? uncontrolled cell growth. The increase in cancer cell proliferation eventually results in tumor formation and, in the worst case, metastatic spread to other organs. Common treatment modalities of cancer include chemotherapy and radiation therapy. However, these methods are associated with severe side effects as well as indu
In this paper, a feature extraction method based on principal component analysis was developed for classification of the vascular access’s condition in hemodialysis patients. The assessment of the method was carried out by discriminating between before and after angioplasty sound recordings as well as before angioplasty and reference recordings. The results showed that when before and after angiop
Popular Abstract in Swedish Antikroppar är viktiga beståndsdelar av det naturliga immunförsvaret som skyddar oss mot smittämnen, såsom bakterier och virus. Utvecklingen av olika genetiska och biokemiska teknologier har dessutom möjliggjort användningen av antikroppar för en mängd ändmål, bl a för diagnostik och behandling av infektionssjukdomar och cancer. I denna avhandling, som bygger på fem vetAntibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. Despite tremendous advances in all fields
Background--Family history of coronary heart disease (CHD) as well as genetic predisposition to CHD assessed by a genetic risk score (GRS) are predictors of CHD risk. It is, however, uncertain to what extent these risk predictors are mediated by major metabolic pathways. Methods and Results--Total effects of self-reported family history and a 50-variant GRS (GRS50), as well as effects mediated by
The interplay of verbal and visual prominence cues has attracted recent attention, but previous findings are inconclusive as to whether and how the two modalities are integrated in the production and perception of prominence. In particular, we do not know whether the phonetic realization of pitch accents is influenced by co-speech beat gestures, and previous findings seem to generate different pre
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear. To obtain insight into this question, a panel of mouse monoclonal antibodies was generated against a major triple helical collagen type II (CII) epitope (position 359-369; ARGLTGRPGDA) with or without arginines modified by cit
Premature prelabor rupture of the fetal membranes affects about 3% of pregnancies. The cause is usually infection, especially at earlier gestations. The prognosis and the risks of delivery are both much worse at earlier gestations. Before viable pregnancy, termination may be offered. Once the fetus is viable, steroids to mature the fetal lungs and antibiotics to reduce infection are the mainstays
A high non-specific binding of immunoglobulins to plastic surfaces was noted with a number of rat sera, when tested in an indirect 125I-labeled protein-A assay for detection of cell-surface-bound rat immunoglobulins of various classes and IgG subclasses. This type of non-specific binding was found with all types of Ig. The degree of binding varied with the type of test plate used and fluctuated wi
Neurotensin regulates both satiety and breast cancer growth in the experimental setting, but little is known about its role in the development of breast cancer or cardiometabolic disease in humans.
The αE integrin chain CD103 identifies a subset of migratory dendritic cells (DCs) in the gut, lung, and skin. To gain further understanding of the function of CD103(+) DCs in regulating adaptive immunity in vivo, we coupled ovalbumin (OVA) to the CD103 antibody M290 (M290.OVA). Intraperitoneal injection of M290.OVA induced OVA-specific CD8(+) and CD4(+) T-cell proliferation in lymph nodes (LNs) o
Abstract Regnell, Astrid: Att se stjärnor på ljusa dagen. Förvandling och försoning i August Strindbergs En blå bok. Seeing stars in broad daylight. Transformation and Reconciliation in August Strindberg’s Zones of the Spirit. In this thesis a pattern of coherence is explored in August Strindberg’s Zones of the Spirit (En blå bok) – a literary work consisting of a collection of short and quite div
Popular Abstract in Swedish Ärftliga orsaker till ledgångsreumatism och Sjögrens syndrom Ett välfungerande immunförsvar är nödvändigt för att kroppen ska kunna mostå angrepp från virus, bakterier och andra mikroorganismer. Vid en autoimmun sjukdom tror man att immunförsvaret av misstag börjar angripa kroppens egna vävnader, vilket leder till att de förstörs. Hur dessa sjukdomar uppkommer känner mTo understand the pathogenesis of autoimmune diseases we have to consider the problem from different angles. Animal models provide a tool to further understand these complex diseases, as the influence of genetic and environmental factors could be limited. Moreover, modern transgenic techniques have made it possible to study the role of certain genes and gene products in the development of diseases
This paper presents a study of the main advantages of inverted decoupling in 2×2 processes. Two simulation examples and an experimental process are used to show these advantages in comparison with simplified decoupling. The study focuses on the following practical advantages: the apparent process is the same as that obtained if one loop changes to manual; bumpless transfer and anti-windup are achi
The current rapid development within work-environment research has created a considerable demand among industrial hygienists for suitable analytical methods. PIXE (particle-induced X-ray emission analysis), which was introduced in Lund in 1970, has been shown to be a feasible method for use in studying the elemental composition of aerosols. However, in some work environments, fluorine, an element
As emphasized by Jeremy Bentham and the analytical school, logical consistency is a requirement for rational legislation. For understanding consistency between norms, a logical scrutiny of normative conflicts is needed. In our paper, a framework for the fine structure of such conflicts is introduced and explained. “Normative conflict” is defined relative the framework and different types of confli
