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A mobile stroke unit (MSU) is a specialized ambulance, enabling to shorten the time to diagnosis and treatment for stroke patients. In the current paper, we present a simulation-based approach to study the potential impacts of collaborative use of regular ambulances and MSUs in prehospital transportation for stroke patients, denoted as co-dispatching. We integrated a co-dispatch policy in an exist
Background: In Europe, approximately 291,000 cardiac arrests occur annually. Despite critical care therapy, hospital mortality remains high. This systematic review assessed whether, in comatose survivors of cardiac arrest, any drug therapy, compared to placebo or usual care, improves outcomes. Methods: We searched Medline, EMBASE, the Cochrane Central Register of Controlled Trials, and The Interna
Extracellular vesicles (EVs) are membrane enclosed biological nanoparticles released by cells. In the past two decades, EVs have gained a lot of attention due to their role in numerous biological processes. However, their small nature complicates isolating them from biological fluids with cumbersome techniques, such as ultracentrifugation. Acoustic trapping is a technique that uses ultrasonic stan
Cancers reprogram macrophages (MΦs) to a tumor-growth-promoting TAM (tumor-associated MΦ) phenotype that is similar to the anti-inflammatory M2 phenotype. Poly(ADP-ribose) polymerase (PARP) enzymes regulate various aspects of MΦ biology, but their role in the development of TAM phenotype has not yet been investigated. Here, we show that the multispectral PARP inhibitor (PARPi) PJ34 and the PARP14
To use conventional ray tracing methods in Monte Carlo simulation of the collimator in a scintillation camera system can be time consuming. It is however necessary to take collimator interactions into account when simulating radionuclides emitting high-energy photons that can penetrate the septa in the collimator. In this work a statistical collimator algorithm, based on the Delta-Scattering metho
We have observed a feature at similar to2.5 eV binding energy (BE) in the valence band of La1-xSrxMnO3 single crystals not previously reported in the literature. The relative intensity of this feature decreases with increasing Sr concentration x and has a strong photon energy dependence. It also exhibits a complicated angle dependence. In this report we present a full set of angular-resolved photo
Popular Abstract in Swedish Avhandlingen handlar om litteraturläsning och litteraturundervisning i grundskolan. Syftet är att belysa den betydelse läsning av skönlitteratur ges i skolans mellanår i början av det tjugoförsta århundradet. Forskningsfrågorna berör de mål och föreställningar om litteratur och läsning som lärare ger uttryck för och hur dessa kommer till uttryck i konkret klassrumsarbetThis dissertation explores the teaching of literature in Swedish compulsory school. The aim of the study is to elucidate different approaches to literature instruction in upper elementary school (grades 4-6, pupils aged 10-13). The research questions focus on what goals and ideas about literature and reading guide teachers and how these are carried out in pedagogical practice and classroom activit
I present the status of the T(HE)PEG project for creating a common platform for implementing C++ event generators. I also describe briefly the status of the new versions of P-YTHIA, (HERWIG) and A(RIADNE) which are implemented using this framework. (c) 2005 Elsevier B.V. All rights reserved.
Introduction. There are few published guidelines for the management of sexual dysfunctions in men and women, despite the prevalence and lack of attention to these problems. Disorders of sexual function in men include erectile dysfunction, orgasm/ejaculation disorders, priapism, and Peyronie's disease. Aim. To provide evidence-based and expert-opinion consensus guidelines for the clinical managemen
In this paper, we introduce a novel framework for semi-parametric estimation of an unknown number of signals, each parametrized by a group of components. Via a reformulation of the covariance fitting criteria, we formulate a convex optimization problem over a grid of candidate representations, promoting solutions with only a few active groups. Utilizing the covariance fitting allows for a hyperpar
Complex product form generation methods have rarely been used within the field of industrial design. The difficulty in their use is mainly linked to constraints – such as functionality, production and cost – that apply to most products. By cou-pling a mathematically described morphology to an optimisation system, it may be possible to generate a complex product form, compliant with engineering and
The European Academy of Dermatology and Venereology (EADV) Task Forces (TFs) on Quality of Life (QoL) and Patient Oriented Outcomes, Melanoma and Non-Melanoma Skin Cancer (NMSC) present a review of the literature and position statement on health-related (HR) QoL assessment in skin cancer patients. A literature search was carried out to identify publications since 1980 that included information abo
Ethical and legal questions of robotic personalisation can be addressed in various ways. While seeking to theorise on ethical issues related to robotic personalisation, this paper proposes the concept of necrorobotics in order to target a particular space of personalisation, governed by a variety of norms: death, and the reuse of dead persons data to create robotic agency. Based on recent advancem
Conventional technical system is designed with all details in the product development phase. Conditions of operation and modes of behaviour are known and validated before the product is launched to the market. This deterministic way of thinking is built into regulations procedures and it is requested at validation when safety is an issue. The existing way of validation that is based on predictive
Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival or neurological outcome for patients randomised to 33 °C or 36 °C, and many hospitals have changed practice. The optimal utilization of TTM is still debated. This study aimed to
Background: Previous research has revealed a clear relationship between weight gain of persons and their metabolic diseases developing later. These studies have covered only short periods lasting 4–8 years. Our goal was to collect decades’ old and often life-long anthropometric data and correlate the figures with the presence of hypertension and diabetes or both. Methods: A retrospective internat
Background: Early restitution of electroencephalogram (EEG) slow wave activity (SWA) may be able to predict favorable functional outcome after cardiac arrest. SWA can be monitored using the C-Trend Index, a recently developed dynamic numerical index computed using commercially available medical device software. Methods: This is a pre-planned prospective substudy of the randomized controlled Sedati
Poor acoustic conditions in learning spaces have a detrimental effect on the speaker's health and constitute a risk factor for voice disorders. Previous research indicates that an acoustic refurbishment of the learning space has the potential to increase well-being and decrease voice-related health problems among teachers, but the research is scarce. In this study, we aim to investigate how differ
BACKGROUNDAmyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.METHODSN-terminal Aβ antibody 6E10 was injected via three di
