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Brevmall STRATEGI 27 Nov 2014 Dnr SAMV 2014/176 Postal address: Box 117, 221 00 Lund Visiting address Stora Algatan 4, Telephone +46 46 222 77 42, +46 46 222 00 00 Fax +46 46 222 41 11 E- mail par.svensson@er.lu.se Website www.lu.se Rektor Lunds universitets strategi för samarbete med Afrika Fastställd av rektor 2014-11-27 A. Sammanfattning Lunds universitet vill stärka sina samarbeten med afrikan
Permanent exposure to pathogens requires decisions toward tolerance or immunity as a prime task of dendritic cells. The molecular mechanisms preventing uncontrolled immune responses are not completely clear. We investigated the regulatory function of Ncf1, an organizing protein of NADPH oxidase, in the signaling cascade of Toll-like receptors. TLR9-stimulated spleen cells from both Ncf1-deficient
Plasmodium falciparum infected red blood cells (iRBC) express variant surface antigens (VSA) of which VAR2CSA is involved in placental sequestration and causes pregnancy-associated malaria (PAM). Primigravidae are most susceptible to PAM whereas antibodies associated with protection are often present at higher levels in multigravid women. However, HIV co-infection with malaria has been shown to al
Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in the general population. It is defined as a serum IgA level below or equal to 0.07 g/l with normal IgM and IgG levels in children over the age of 4. However, a few cases of reversal of IgAD at later ages have been observed previously, especially in pediatric patients. This study aimed at investigating the frequency of
OBJECTIVE - Impaired muscular mitochondrial function is related to common insulin resistance in type 2 diabetes. Mitochondrial diseases frequently lead to diabetes, which is mostly attributed to defective beta-cell mitochondria and secretion. RESEARCH DESIGN AND METHODS - We assessed muscular mitochondrial function and lipid deposition in liver (hepatocellular lipids [HCLs]) and muscle (intramyoce
Popular Abstract in Swedish Immunförsvaret har till uppgift att skydda kroppen mot främmande mikroorganismer såsom bakterier och virus. En rad olika celler, vävnader samt organ samarbetar för att utforma ett väl fungerande immunförsvar. Det är ytterst viktigt att immunförsvaret känner igen kroppsfrämmande ämnen (antigen), som till exempel bakterieceller, men också att det skiljer dessa från kroppsGeneration of long-lived plasma cells and memory B cells of high affinity takes place in germinal centers and depends on help from a specialized CD4+ T cell subset termed T follicular helper (Tfh) cells. These processes are crucial for long-term protection upon natural infection or in settings of vaccination, however they are also responsible for development of antibody-mediated autoimmune disease
Chronic granulomatous disease (CGD) is an inherited disorder characterized by recurrent life-threatening bacterial and fungal infections. CGD results from defective production of reactive oxygen species by phagocytes caused by mutations in genes encoding the NADPH oxidase 2 (NOX2) complex subunits. Mice with a spontaneous mutation in Ncf1, which encodes the NCF1 (p47(Phox)) subunit of NOX2, have d
Characteristics of nanoscale materials are often different from the corresponding bulk properties providing new, sometimes unexpected, opportunities for applications. Here we investigate the properties of 8 nm colloidal nanoparticles of MAPbBr3 perovskites and contrast them to the ones of large microcrystallites representing a bulk. X-ray spectroscopies provide an exciton binding energy of 0.32 ±
Alternative macrophage activation is implicated in diverse disease pathologies such as asthma, organ fibrosis, and granulomatous diseases, but the mechanisms underlying macrophage programming are not fully understood. Galectin-3 is a carbohydrate-binding lectin present on macrophages. We show that disruption of the galectin-3 gene in 129sv mice specifically restrains IL-4/IL-13-induced alternative
This thesis covers aspects of the mature human B cell and its different guises on its way to become a fully differentiated antibody forming plasma cell (AFC), the key player in the humoral immune system. The understanding of the complex molecular mechanisms taking place in the B cell, as it first encounters antigen, enters the germinal center (GC) reaction, giving rise to memory cells and plasma c
It is shown that the high-resolution laser photoelectron microscope withsubwavelength-spatial resolution can be used for an absolute values ofthe two-photon external photoelectric effect measurements with high (afew nm-scale) localization. The spatial distribution of light intensityin the near field is studied by observing the photoelectron projectionimages of a subwavelength nanoaperture. The ima
Denna bok handlar om de franska S:t josefsystrarna och deras missionsverksamhet i Skandinavien från mitten av 1800-talet och fram till 1950-talet med fokus på deras skol- och sjukvårdsverksamhet samt den specifika kvinnokultur som de representerade.Female Counter-Culture and Catholic Mission. The St Joseph Sisters in Denmark and Sweden 1856-1936 In May 1856, four Catholic sisters arrived in Denmark and established a community in a small basement of a building close to the Catholic parish church in Copenhagen. These Catholic sisters belonged to a French religious congregation named "La Congregation des Sœurs de Saint-Joseph de Chambéry", whi
Platelet activating factor (PAF) has been reported to produce a variety of airway effects including epithelial damage and increased airway-lung absorption of hydrophilic tracers. The present study examines effects of PAF on the guinea-pig tracheobronchial mucosa in vivo. Vehicle with and without PAF (4.0 and 8.0 nmol) was superfused onto the tracheobronchial mucosa. The levels of 125I-albumin, pre
After infection with Borrelia burgdorferi, humans and mice under certain conditions develop arthritis. Initiation of inflammation is dependent on the migration of innate immune cells to the site of infection, controlled by interactions of a variety of adhesion molecules. In this study, we used the newly synthesized compound S18407, which is a prodrug of the active drug S16197, to analyze the funct
The ERP market has been changing since the implementation peaks observed around Y2K, when most of the high-end adopters take their chance of substituting legacy systems while implementing integrated management. This adoption movement from bigger companies created a reaction on the Small and Medium-sized Enterprises (SMEs) ERP market: on the vendor side, it was necessary to find new market segments
We present characterizations of the attosecond pulse train produced in the high harmonic generation (HHG) from SF6 molecules irradiated by a strong pulsed laser field at 800 nm. At harmonic order 17, we observe a minimum in the amplitude of the emitted spectrum and a corresponding distortion in the phase. Our experimental results are compared to two models: a multicenter interference model focused
