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Stages in the development of perceptual intersubjectivity

We offer an analysis of perceptual intersubjectivity (PI) in terms of two types (symmetric and asymmetric) and three levels: synchronous (SPI), coordinated (CPI) and reciprocal (RPI), defined on the basis of the observable behavior of the participants in a study of (non-verbal) social interaction. We hypothesize that the three levels constitute stages in the development and possibly evolution of h

Autoimmune (type 1) diabetes

Autoimmune (type 1) diabetes (AI-DM) is a multistage disorder. Children are born genetically predisposed to putative environmental exposures. These trigger an aggressive, selective and chronic autoimmune response against the pancreatic islet beta cells. This stage is marked by autoantibodies against insulin, glutamic acid decarboxylase (GAD65), IA-2 and the ZnT8 transporter. Progression to clinica

Ethane thermometry using rotational coherent anti-Stokes Raman scattering (CARS)

The complete rotational CARS (coherent anti-Stokes Raman scattering) spectrum of ethane (C2H6) has for the first time been recorded instantaneously under high spectral resolution, and the potential for thermometry has been investigated. Experiments were performed in the temperature range 292-650K in pure ethane and in binary mixtures with nitrogen. A polarization technique was used to suppress the

Integration of particle-gas systems with stiff mutual drag interaction

Numerical simulation of numerous mm/cm-sized particles embedded in a gaseous disk has become an important tool in the study of planet formation and in understanding the dust distribution in observed protoplanetary disks. However, the mutual drag force between the gas and the particles can become so stiff - particularly because of small particles and/or strong local solid concentration - that an ex

CD8αβ+ γδ T cells : A novel T cell subset with a potential role in inflammatory bowel disease

γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology of γδ T cells it is crucial to define the constituting subpopulations. γδ T cells have previously been categorized into two subpopulations: CD8aa+ and CD8- cells. In this study we have defined and characterized a novel subset of human γδ T-cells e

The Evolving Heritagescape: Actors and Narratives in Xinye village

The threat to the rural heritage has since the 1990s become a concern for Chinesescholars and heritage experts. Today many individual buildings and whole villageshave been listed as protected sites at different levels. But long before experts began totake an interest, villagers were themselves actively involved in protecting their owntraditions and the buildings of importance to the community (in

Identifying stellar streams in Gaia DR2 with data mining techniques

Streams of stars from captured dwarf galaxies and dissolved globular clusters are identifiable through the similarity of their orbital parameters, a fact that remains true long after the streams have dispersed spatially. We calculate the integrals of motion for 31 234 stars, to a distance of 4 kpc from the Sun, which have full and accurate 6D phase space positions in the Gaia DR2 catalogue. We the

Purine Metabolites and Carnitine Biosynthesis Intermediates Are Biomarkers for Incident Type 2 Diabetes

CONTEXT: Metabolomics has the potential to generate biomarkers that can facilitate understanding relevant pathways in the pathophysiology of type 2 diabetes (T2DM). METHODS: Nontargeted metabolomics was performed, via liquid chromatography-mass spectrometry, in a discovery case-cohort study from the Malmö Preventive Project (MPP), which consisted of 698 metabolically healthy participants, of whom

Observer Backstepping and Control Design of Linear Systems

We show that the observer-backstepping technique applied to linear control object and combined with linear control system design gives rise to a non-standard composition of control object, observer and controller. The resultant system is characterized by a full-order observer and a reduced-order control system design which in its complexity does not go beyond the `relative degree' of the control o

Relative and absolute lung function change in a general population aged 60-102 years

Data on longitudinal lung function change in the elderly are scarce. Uncertainty remains about whether to use absolute or relative change and how it relates to subject demographics.We studied absolute and relative forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) change in a population-based geriatric sample using a repeated measurements model adjusted for age, sex, smoking ha

Stability Analysis of Adaptive Output Feedback Systems

This paper presents stability theory of adaptive systems using an extension of the Yakubovich-Kalman-Popov (YKP) lemma. Adaptive stability analysis is relevant for observer-based feedback control systems. Relaxation of the controllability and observability conditions imposed in the YKP lemma can be made for a class of adaptive systems described by a linear time-invariant system (LTI) with adaptive

The Fragility of Religious Freedom

One implication of freedom of religion is that the State must accept a variety of religious beliefs and practices. Yet, not everything can be accepted. One way of dealing with such a conflict is to state that freedom of religion is absolute in so far that it does not infringe upon some other more important value. Another way is to limit what is considered ‘religious.’ Both these ways are insuffici