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Correlated dynamics of consecutive residues reveal transient and cooperative unfolding of secondary structure in proteins

Nuclear spin relaxation is a powerful method for studying molecular dynamics at atomic resolution. Recent methods development in biomolecular NMR spectroscopy has enabled detailed investigations of molecular dynamics that are critical for biological function, with prominent examples addressing allostery, enzyme catalysis, and protein folding. Dynamic processes with similar correlation times are of

Pressurized DNA state inside herpes capsids-A novel antiviral target

Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat all nine human herpesviruses and animal herpesviruses. The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pre

Making massive stars in the Galactic Centre via accretion on to low-mass stars within an accretion disc

The origin of the population of very massive stars observed within ∼0.4 pc of the supermassive black hole in the Galactic Centre is a mystery. Tidal forces from the black hole would likely inhibit in situ star formation whilst the youth of the massive stars would seem to exclude formation elsewhere followed by transportation (somehow) into the Galactic Centre. Here, we consider a third way to prod

Generation and control of light

This chapter describes various kinds of artificial light sources of interest to the photobiologist (natural light is described in separate chapters), starting with incandescent lamps and their properties, and continuing with gas discharge lamps, flashlamps and lasers. After a section on light filters the chapter concludes with a treatment of monochromators, in which the mode of action of a grating

Diversity and phylogeny of mitochondrial cytochrome b lineages from six morphological species of avian Haemoproteus

Species of Haemoproteus (Haemosporida: Haemoproteidae), avian haemosporidians, have traditionally been described based on morphology of their gametocytes and on limited experimental information on their vertebrate host specificity. We investigated to what extent the morphological species are represented by monophyletic groups based on DNA sequence data using 2 different fragment lengths of the cyt

Review Topography of Sound Art

Austrian artist and director of ZKM Center for Art and Media in Karlsruhe, Germany, Peter Weibel (Odessa, 1944), curates a book/catalogue of the mythical exhibition Sound Art, Sound as Medium of Art, that took place between March 2012 and February 2013 in Karlsruhe, with nearly one thousand images of sound art pieces. Along with a very detailed historical trace of sound as a form of art, the book

A Collective Picture of What Makes People Happy: Words Representing Social Relationships, not Money, are Recurrent with the Word ‘Happiness’

The Internet allows people to freely navigate through news and use that information to reinforce or support their own beliefs in, for example, different social networks. In this chapter we suggest that the representation of current predominant views in the news can be seen as collective expressions within a society. Seeing that the notion of what makes individuals happy has been of increasing inte

Activist Learning for Sustainability : A Pedagogy for Change

This chapter explores the concept of “activist learning for sustainability” and the role of activism and related pedagogies and the relationship to education for sustainable development (ESD). The chapter will reflect on a case study of student-led activism: the initiation of a “sustainable student house” devised and developed by students to allow them to “live what they are learning” and educate

Dersim 1937-38 : Shifts and continuities in the state discourse and reasoning under Kemalism and Erdoğanism

This chapter analyzes the changing accounts of Dersim from 1937 to 1938 in the dominant state discourse as well as subjugated narratives of the oppressed and argues that Erdoğan’s Dersim ‘apology’ instrumentalized the traumatic history of Dersim and the Dersim community not only to disgrace his rival party CHP and to discredit its Dersimli leader Kemal Kılıçdaroğlu, but also to challenge Kemalism