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Purpose: The platelet-derived growth factor (PDGF) signalling pathway is often dysregulated in cancer and PDGF-receptor expression has been linked to unfavourable prognostic factors in breast cancer (e.g. ER negativity, high Ki67 and high grade). This study aimed to evaluate the expression of PDGFRα, PDGFRβ and ligand PDGF-CC in breast cancer in relation to molecular subtypes and prognosis. Method

Objectives: Asthma and allergic diseases are the most frequent chronic diseases in childhood worldwide, and considered a burden for the affected children and their families. The diseases impose an economic burden on society if not diagnosed and treated properly and management of and these diseases are challenging for healthcare professionals. The aim of the present investigation was to assess the

Motivation: Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human-induced environmental changes are compromising the long-term persistence of plant-pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant-pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant-

Background: Swimming ability among children in the city of Malmö, Sweden is strongly affected by socioeconomic differences. We investigated to what extent mediating health and lifestyle factors, such as children’s eating, sleeping and physical activity habits, as well as the characteristics of the social and working environment at both school and home, could explain the socioeconomic gradient in s

This paper proposes a wireless and stretchable sensor which uses an oscillator with an inductively coupled resonator. By delving into the malleable nature of these cutting-edge electronics, we determine the most effective circuit parameters to optimize signal behavior for specific applications. The findings showed that the simulated frequency shift sensitivity to variations in sensor resistance in

The number of degrees of freedom (NDoF) in a communication channel fundamentally limits the number of independent spatial modes available for transmitting and receiving information. Although the NDoF can be computed numerically for specific configurations using singular value decomposition (SVD) of the channel operator, this approach provides limited physical insight. In this paper, we introduce a

Efterfrågan på biologiska läkemedel blir allt större, i och med att det med tiden upptäckts fler användningsområden för till exempel antikroppar, enzymer och virus. Dessa har i många fall blivit standardläkemedel för att behandla till exempel diabetes, vissa neurologiska sjukdomar och HIV/AIDS. Biologiska läkemedel känneteckas av att produceras av celler som genetiskt har modifierats. Från dessa cThis thesis addresses a challenge in continuous high performance liquid chromatography (HPLC): ensuring reliable, timely supply of buffer solutions. As biopharmaceutical production increasingly moves toward continuous operation, buffer management becomes critical, since chromatography requires multiple buffer types with precise compositions for washing, elution, equilibration, and regeneration. In

Peak to average power (PAPR) reduction of OFDM signals is critical in order to improve power amplifier (PA) efficiency in base stations. For massive MIMO, the complexity of these methods can become a real bottleneck in implementing low power digital signal processing chains. In this work, we consider an antenna reservation technique, which uses a low complexity clipping method to reduce signal pea

This paper presents measurement and analysis results for millimeter-wave (mmWave) massive multiple-input multiple-output (MIMO) performance in different real-life scenarios with moderate user equipment (UE) mobility. For the measurement campaign, the developed massive MIMO testbed operating at 28GHz called LuMaMi28GHz is employed. In this testbed, the base station has 16 transceiver chains with a

We derive the expression of the loop gain in a circuit containing one or more feedback loops, where the transfer functions building the expression are found by means of a few AC analyses on the circuit. No approximations or assumptions on the nature of the loop or of the impedances therein contained are necessary. While hand calculations are certainly possible in the case of simpler circuits, the

Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous proble

Aim: Children born extremely preterm frequently have developmental coordination disorder (DCD). We aimed to evaluate perinatal risk factors for DCD. Methods: Swedish national cohort study including 226 children born before 27 gestational weeks without major neurodevelopmental disabilities at 6.5 years. Outcome was DCD, defined as ≤5th percentile on the Movement Assessment Battery for Children-Seco

Body: Background: Estrogen receptor (ER) positive HER2-negative breast cancer comprises 75–80% of all breast cancer. Thisfraction is even higher (>90%) in invasive lobular carcinoma (ILC). According to the St Gallen surrogate definitions of the intrinsicsubtypes, Ki67 and progesterone receptor (PgR) are used to classify these tumors as luminal A- and luminal B-like(HER2-negative). These guidelines

AIMS/HYPOTHESIS: Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiometabolic outcomes, which may not be the case. In this study, we investigated the shapes of the causal relationships between BMI and cardiometabolic dis

This guide presents a joint effort of projects funded under the European Research Area for Climate Services (ERA4CS) (http://www.jpi-climate.eu/ERA4CS), a co- funded action initiated by JPI Climate with co-funding by the European Union (Grant 690462), 15 national public Research Funding Organisations (RFOs), and 30 Research Performing Organisations (RPOs) from 18 European countries. This guide set

On the 18th of December 2014, the Court of Justice of the European Union delivered the historic Opinion 2/13, where it ruled that the draft agreement on the accession of the European Union to the European Convention for the Protection of Human Rights and Fundamental Freedoms is not compatible with Article 6(2) of the Treaty on European Union or with Protocol (No 8) relating to Article 6(2) TEU.In

Hardware distortion in large intelligent surfaces (LISs) may limit their performance when scaling up such systems. It is of great importance to model the non-ideal effects in their transceivers to study the hardware distortions that can affect their performance. Therefore, we have focused on modeling and studying the effects of nonlinear RX-chains in LISs. We first derive expressions for SNDR of a

This paper presents the exploration of GPU-accelerated block-wise decompositions for zero-forcing (ZF) based QR and Cholesky methods applied to massive multiple-input multiple-output (MIMO) uplink detection algorithms. Three algorithms are evaluated: ZF with block Cholesky decomposition, ZF with block QR decomposition (QRD), and minimum mean square error (MMSE) with block Cholesky decomposition. T