Popular Abstract in Swedish Neutrofiler försvarar oss mot sjukdomsframkallande mikroorganismer. Deras primära funktion är att känna igen, fagocytera och avdöda de invaderande mikroorganismerna. I denna avhandling studeras membrantrafik i neutrofiler och neutrofil-lika celler. Här visas att icke-opsoniserade S. pyogenes bakterier inducerar ett snabbt och lokaliserat pinocytossvar hos neutrofiler. PThe neutrophil constitutes the first line of defence against invading organisms and its primary function is to recognize, phagocytose and kill intruding microorganisms. In this thesis, the membrane traffic in neutrophils and neutrophil-like cells was studied. Non-opsonised S. pyogenes bacteria was shown to induce a rapid and localised pinosome formation in neutrophils. The pinocytosis was not an i

We have analysed an extracted RNase sensitive fraction containing telomeric repeat sequences in the telomerase negative dipteran Chironomus tentans. It shows a slow and well-defined electophoretic migration corresponding to > 20 kb and is sensitive not only to RNase, but also to DNase. It hybridizes to both strands of the telomeric repeat with about equal intensities. DNA is probably the dominant

Dimethylaminopurine (DMAP) has previously been used as an inhibitor of phosphorylation in studies of meiotic events, and more recently to investigate TNFα signaling, because of its potential to inhibit activation of c-jun N-terminal kinase (JNK). Here we have addressed the effects of DMAP on metabolic insulin responses in adipocytes and on intracellular insulin signaling molecules. At 100 μmol/L,

The Eae2 locus on mouse chromosome 15 controls the development of experimental autoimmune encephalomyelitis (EAE); however, in this study we show that it also controls collagen-induced arthritis (CIA). To find the smallest disease-controlling locus/loci within Eae2, we have studied development of CIA in 676 mice from a partially advanced intercross. Eae2 congenic mice were bred with mice congenic

The European hummingbird hawkmoth, Macroglossum stellatarum (Linnaeus 1758), drinks nectar while hovering in front of flowers of all colours, odours, sizes and shapes. Naive moths orient predominantly towards visual stimuli and prefer blue flowers with a radial pattern and a central contrasting spot. Hummingbird hawkmoths have trichromatic colour vision and can learn any colour and different patte

Background: Smoking in pregnancy is a well-documented risk factor for fetal growth impairment and poor perinatal outcomes. Less is known about the long-term effects of maternal smoking on offspring mortality. Methods: A follow-up study in national registers on total mortality and cancer based on a birth cohort from Helsingborg, Sweden, including data on 2,010 sons and 1,982 daughters born to mothe

Background: The role of glycemic index (GI) in appetite and body-weight regulation is still not clear. Objective: The objective of the study was to investigate the long-term effects of a low-fat, high-carbohydrate diet with either low glycemic index (LGI) or high glycemic index (HGI) on ad libitum energy intake, body weight, and composition, as well as on risk factors for type 2 diabetes and isc

A new type of triangular phase diagram has been developed in which both the volume fractions and the shrinkage modes can be visualised and compared for the consolidation process in the paper dryer. The triangular phase diagrams show the development of the solid, the liquid and the gas volume fractions as well as the shrinkage relative to either ideal or no shrinkage of the sheets. Analysis showed

Ancient Italic terracottas were painted before or after firing depending on their function, as suggested by previous analyses. However, concerning the votive terracottas, there seems to have been no anlayses carried out, suggesting either a fired or non fired paint. Methods and problems associated with an ongoing research on some votive terracottas from Tessennano in Southern Etruria are considere

Rare-earth-doped crystals can be attractive materials for quantum information processing, because of the long coherence times that can be expected, in particular, from non-Kramers ions. In this paper, Ho3+-doped yttrium and lutetium vanadate single crystals have been investigated using linear and coherent optical spectroscopy. For Ho3+:YVO4, the crystal-field levels of the I-5(8), F-5, F-5(4) and

Popular Abstract in Swedish Kambrium är ett tidsavsnitt av jordens historia som spänner från ca 542 till 488 miljoner år sedan. Under denna tid utvecklades livet, främst djur, i en rasande takt genom något som brukar kallas den kambriska explosionen, en ekologisk förändring utan dess like. Bland de nya livsformer som fick de kambriska haven att koka av liv märks skalbärande djur som små armfotingaThis thesis is based on studies of Cambrian successions in Sweden, with particular focus on the middle Cambrian biostratigraphy and its correlative relationship to the proposed global agnostoid zonation. The investigated material, mainly trilobites, was collected from both outcrops and drill cores from five provinces in Sweden: Skåne (Scania), Öland, Västergötland, Jämtland and Lapland. The Almba

We consider the problem of covering arbitrary polygons with rectangles. The rectangles must lie entirely within the polygon. (This requires that the interior angles of the polygon are all greater than or equal to 90 degrees.) We want to cover the polygon with as few rectangles as possible. This problem has an application in fabricating masks for integrated circuits. In this paper we will describe