Serine protease inhibitors in the upper and lower airways
Popular Abstract in Swedish Kliniska och experimentella studier har visat att proteaser och deras inhibitorer deltar i mycket hög grad i luftvägarnas fysiologi och sjukdomsutveckling. Inflammatoriska celler, såsom neutrofiler, monocyter/makrofager, epitel- och mastceller, friger olika proteaser. Det är allmänt känt att ökad produktion eller aktivitet av proteaser eller inaktivering och minskad proProteases and their inhibitors are implicated in the physiology and pathology of the airways. Protease inhibitors include those produced locally, such as secretory leukocyte protease inhibitor (SLPI), and those produced mainly by the liver that can reach the airways via passive diffusion, such as alpha1-antitrypsin (AAT). SLPI is a significant component of the anti-neutrophil elastase shield in th