PACAP in adult sensory neurons - implications in injury and pain
Popular Abstract in Swedish I denna avhandling undersöktes förekomsten och regleringen av neuropeptiden PACAP (pituitary adenylate cyclase-activating polypeptide) i det sensoriska nervsystemet hos råtta och mus och hur de normala nivåerna av PACAP ändrades vid olika betingelser som t.ex. nervavskärning och lokal inflammation. Dessutom undersöktes PACAPs roll vid smärta genom att studera om smärtsvThe data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. PACAP is one of the excitatory neuropeptides expressed in small sized DRG ne