Sökresultat

Background: alpha1-antitrypsin (AAT) is one of the major serine proteinase inhibitors controlling proteinases in many biological pathways. There is increasing evidence that AAT is able to exert other than antiproteolytic effects. To further examine this question we compared how various doses of the native (inhibitory) and the polymerised (non- inhibitory) molecular form of AAT affect pro-inflammat

A survey of reservation-based CPU scheduling, developed as a part of the VINNOVA project FISS2 and of the EU project ACTORS The field of Reservation-based scheduling is presented. A brief history is given together with an in-depth look at the main classes of reservation-based scheduling algorithms. An overview of important publicly available implementations of reservation-based schedulers is prov

Object. The authors investigated whether cyclosporin A (CsA), a cyclophilin ligand with mitochondrial permeability transition pore-blocking and calcineurin-inhibiting properties, affects motor function, neuronal death, and life span in the G93A transgenic mouse model of familial amyotrophic lateral sclerosis (FALS). Methods. The G93A mice received weekly intracerebroventricular injections of CsA (

A clinical case of human granulocytic ehrlichiosis in Scandinavia is presented. The patient developed high fever, myalgia, headache and dyspnoea. Doxycycline treatment resulted in a dramatic improvement. Laboratory confirmation Included a fourfold change in anti-Ehrlichia equi IFA titre and a positive PCR confirmed by gene sequence analysis.

Macroscopic phase separation in covalent sodium polyacrylate (PA) networks following the absorption of cetyltrimethylammonium bromide/chloride (CTAB/C) from aqueous solutions is studied experimentally and theoretically. The gels are shown to consist of a solvent-swollen polyelectrolyte network (core), surrounded by a dense surface phase (skin) of polyion/surfactant complexes. The effect of core sw

Papaya proteinase IV (PPIV) is not inhibited by chicken cystatin, or human cystatins A or C, unlike most other proteinases of the papain superfamily. The enzyme inactivates chicken cystatin and human cystatin C by limited proteolysis of the glycyl bond previously shown to be involved in the inhibitory inactivity of the cystatins, but has no action on cystatin A. Contamination of commercial crystal

Sixty-four adult patients operated on for isolated cleft palate were evaluated with regard to facial skeletal morphology using conventional radio-cephalometry. Dental occlusion was assessed clinically. Forty-two had had a von Langenbeck repair at the age of 7 months and 22 a Wardill repair at 18 months. The mean error of the method was 0.7 degree for angular, and 0.9 mm for linear, measurements. T

This study highlights school nurses' view of schoolchildren's health and their attitude to document it in the school health records. A strategic sample of 12 school nurses was interviewed. The interviews were semistructured and analysed with qualitative content analysis. The findings showed that the school nurses' viewed schoolchildren as physical healthy although they called attention to growing

Software process improvement involves evaluation of process change proposals, and it is important to evaluate changes as early as possible. A process impact analysis method for interview based evaluation of change proposals is presented. It is based on the subjective opinions of people in the organisation, and it is carried out in three steps. In the first step, the impact on sub-processes is est

The mechanism of templated synthesis of ordered mesoporous alumina according to the recipe proposed by Yada et al. (Yada, M.; Machida, M.; Kijima, T. Chem. Commun. 1996, 769) using sodium dodecyl sulfate (SDS) as template, has been investigated by NMR self-diffusion and spin and fluorescence probe techniques. In the precursor solutions urea was found to produce a substantial shortening of the long

The enzymatic depolymerization of the pectic substance polygalacturonic acid (PGA) is studied in batch reactor. The number-average molecular weight of native substrate is estimated, using a simple and quick technique, to be approximately 11.1 kDa, the polymeric chains consisting on average of 63 galacturonic acid units. The effect of enzyme concentration was studied varying biocatalyst loading fro

Greyerz varnar för dogmatism (att kalla förfädernas religionsutövning irrationell eller vidskeplig) och reduktionism (Marx, Durkheim). Kulturella förlopp är förbundna med sociala, men kan inte reduceras till sådana. Boken behandlar äktenskap och familj, folkreligiositet som kollektiv ritual och förhållandet till de utstötta (judar, häxor), samt även vederdöpare, baptister, kväkare och radikalpieti

A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of insulin secretion. In the present study we combined electron microscopy, insulin secretion measurements and recordings of cell capacitance in an attempt to define this pool ultrastructurally. Mouse pancreatic B-cells contain approximately 9,000 granules, of which 7% are docked below the plasma membrane. Th

The functional role of aerobic lactate production in the rat portal vein was investigated. Changing substrate from glucose (11.5 mM) to pyruvate (11.5 mM) or beta-hydroxybutyrate (3 mM) had virtually no effect on spontaneous mechanical activity. Lactate production (FLA) was smaller with pyruvate than with glucose (0.05 +/- 0.01 vs. 0.14 +/- 0.03 mumol g-1 min-1, n = 4). Addition of 0.5 mM iodoacet