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Hur kan cancerbehandling öka risken för hjärt- och kärlsjukdomar? PD1-inhibitorer är en revolutionerande, ny typ av cancerbehandling som gör immunförsvaret starkare och ihärdigare i kampen mot tumörer. Tyvärr kan denna behandling leda till immunaktivering mot kroppens egna organ, till exempel hjärtat och kärlväggen. PD1-inhibitorer har visat sig öka risken för dessa sjukdomar markant, bland annatAtherosclerosis, the formation of inflammatory plaques in the arterial walls, is the most common underlying cause behind cardiovascular disease (CVD). The risk of atherosclerosis has been shown to increase following immune checkpoint inhibitor therapies such as anti-PD1. Anti-PD1 therapy has revolutionized cancer treatment as it blocks the immune checkpoint receptor PD1, preventing T cell exhausti

Deciphering where genes are expressed within the complex architecture of cells and tissues requires advanced spatial transcriptomics techniques. This study focuses on Multiplexed Error-Robust Fluorescence In Situ Hybridization (MERFISH), a technique for spatial transcriptomic. The MERFISH experiment involves probes binding to specific RNA-targeted sequences within fixed cells and tissues. I develo

GPS tracking technologies are essential to follow long-distance migratory species throughout their annual cycle and identify the threats they encounter at large geographical scales. Information on the “lost” years of juvenile individuals of many species is lacking and it is vital to uncover their movements during these critical early stages. The Baltic Lesser Black-backed Gull (L. f. fuscus), a lo

This thesis views Sankt Lars begravningsplats (cemetery) as a deathscape where histories of institutionalization, social exclusion, and neoliberal expansion are spatially materialized in the cemetery’s ecology. Tied to the former Sankt Lars asylum on the margins of Lund, Sweden, the cemetery embodies the intersections of human and nonhuman forces where ecological transformations intertwine with cu

Lon Fuller famously argued that polycentric issues are not readily amenable to binary and adversarial forms of adjudication. When it comes to resource allocations involving various interested parties, binary polemical forms of decision making may fail to capture the polycentric nature of the dispute, namely the fact that an advantage conferred to one party invariably involves (detrimentally) affec

Understanding the drivers of diversity and change in regional Neolithization trajectories has emerged as a major theme in World Prehistory with new insights appearing in many parts of the globe. In Northeast Asia, research on Neolithic transition over the past two decades has focused primarily on millet and rice domestication and their role in the rise of farming, social complexity, and early Chin

Patients with chronic lymphocytic leukemia (CLL) have an impaired response to vaccination, which calls for improved vaccination strategies. This study aimed to evaluate antibody persistence 5 years after pneumococcal vaccination and response to revaccination. Seventy-four CLL patients and 31 controls, all primary immunized with 13-valent conjugated pneumococcal vaccine (PCV13) or 23-valent polysac

This thesis examines how parody and satire are used in contemporary Americananimated television series. Through critical textual analysis, five television shows are examined. These are Archer, BoJack Horseman, My Little Pony: Friendship is Magic, Rick and Morty, and South Park. The study offers theoretical background and discussion on key concepts like parody, satire, comedy, animation, television

In an era where online interactions increasingly shape social dynamics, the pervasive issue of cyberbullying poses a significant threat to the well-being of individuals, particularly among vulnerable groups. Despite extensive research on text-based cyberbullying detection, the rise of visual content on social media platforms necessitates new approaches to address cyberbullying using images. This d

Vilken roll spelar beprövad erfarenhet i socialtjänstens beslutsfattande? I det här kapitlet undersöks hur socialsekreterare inom områdena barn och unga samt vuxna med beroendeproblematik använder och delar kunskap i en komplex vardag präglad av krav på rättssäkerhet, evidens och effektivitet. Genom fokusgruppsintervjuer synliggörs det kollegiala lärandets betydelse och hur erfarenhetsbaserad kuns

Background: Ex-vivo perfusion of donor hearts is gaining importance in minimizing ischemia-reperfusion injury during heart transplantation. The Non-Ischemic Heart Preservation (NIHP) device, developed in 2016, has shown promising results in pilot studies. This study aims to compare the mid-term follow-up outcomes of NIHP with traditional Static Cold Storage (SCS) in heart transplantation. Methods:

We study the first-order phase transitions and the emerging stochastic gravitational wave spectrum in a minimal leptoquark extension of the Standard Model that explains active neutrino oscillation data, while satisfying current flavor physics constraints. This model exhibits diverse phase transition patterns, including color symmetry-breaking scenarios in the early Universe. Strong correlations be

Large-scale genomic resources can place genetic variation into an ecologically informed context. To advance our understanding of the population genetics of the fruit fly Drosophila melanogaster, we present an expanded release of the community-generated population genomics resource Drosophila Evolution over Space and Time (DEST 2.0; https://dest.bio/). This release includes 530 high-quality pooled

Artiklen analyserer, hvordan danske efterretningstjenester kan opretholde offentlig tillid i en tid præget af hybride trusler, øgede beføjelser og faldende autoritetstro. Tillid er afgørende for demokratisk legitimitet, men hemmeligholdelse og skandaler udfordrer den. Behovet for begrundet tillid baseret på indsigt frem for blind tillid fremhæves som centralt, og to væsentlige pointer diskuteres:

This article examines the fire and rescue services sector in Sweden in the period 1986–2021, and explains the timing of bureaucratic reforms using the Multiple Streams Framework (MSF). In this study, we insert institutions in MSF by employing a two-level analysis; we highlight the interactions among experts acting as policy entrepreneurs over time and during a large window of opportunity, and we s

Context. Globular clusters exhibit star-to-star chemical variations that are traceable through both photometric and spectroscopic data. While UV photometry and light-elements such as Na and O are commonly used for this purpose, the optical V versus (V-I) color magnitude diagram (CMD) is often assumed to be relatively unaffected by such inhomogeneities and is used to derive basic cluster parameters