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Background/Objectives: Intraoperative frozen biopsies are essential during surgery for Hirschsprung’s disease (HD). However, this method has several limitations with the need for a faster and real-time diagnostic alternative. For this, consistent histoanatomical and morphometric differences between aganglionic and ganglionic bowel must be established. The primary objective was to compare dimension

In this paper, we investigate how adaptive time-integration strategies can be effectively combined with parallel-in-time numerical methods for solving systems of ordinary differential equations. Our focus is particularly on their influence on tolerance proportionality. We examine various grid-refinement strategies within the multigrid reduction-in-time (MGRIT) framework. Our results show that a si

The Kunming-Montréal Global Biodiversity Framework, adopted at COP15, establishes a clear mandate to mobilize funding from diverse sources to address the escalating biodiversity crisis. Despite growing awareness and commitment to biodiversity conservation, a substantial financing gap persists, hindering efforts to protect and restore ecosystems effectively. This chapter provides an in-depth examin

Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA. This study investigates CAC scores in patients with r-axSpA compared to controls without rheumatic disease and factors associated with CAC scores in r

Background: Treatment with antihypertensives in patients with advanced cancer is often continued until very late in the disease trajectory, despite a considerable risk of hypotension. Objectives: The aim of this study was to investigate the time of deprescribing of antihypertensive agents in patients with cancer receiving palliative care during their last year of life. The monitoring of blood pres

Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis

Alzheimer's disease (AD) is a neurodegenerative disease that often occurs in the elderly and is often accompanied by cognitive loss. Its main pathological features are the formation of amyloid-beta (Aβ) plaques and Tau tangles in the brain. Here, we used single-cell RNA sequencing (scRNA-seq) combined with computational cell–cell communication (CCC) analysis to systematically investigate trans

Papain-like protease (PLpro) of SARS-CoV-2 is a vital enzyme involved in viral polyprotein processing and in the suppression of host immune response. Due to its strategic role in viral replication and pathogenesis, PLpro represents a valid yet challenging target for drug development. Fragment-based drug discovery (FBDD) is a powerful strategy employed by the FragMAX facility at MAX IV to identify

Landskronas öppna verkstad undersöker hur ett mindre tillägg i en urban kontext kan bidra till en ökad aktivering av närområdet och samtidigt ge utrymme för ökad rörelse från resten av staden. Projektet tar sin utgångspunkt i ambitionen att skapa ett genomarbetat förslag som förhåller sig till de funktionella krav som ställs, samtidigt som det är starkt förankrat i sin kontext. Projektet prövar id

Consistent behavioural differences among individuals can have significant ecological and evolutionary consequences, yet their origins and persistence within populations have proven challenging to determine. In newly established populations at expanding range margins, behavioural variation may result from natural selection and spatial sorting, with behavioural types that promote dispersal being mor

Två flugarter: mer alkohol, mer sex? Artbildning är en av de viktigaste processerna inom evolutionsbiologi. För att en art ska bli två krävs det att arten formar två grupper som inte reproducerar sig med varandra. Om en sådan reproduktiv isolering, som det kan kallas, fortgår i flera generation kan så pass många genetiska skillnader åsamlas mellan grupperna att hybrider (avkommor från två olika tSexually reproducing species tend to have reproductive barriers between them that prevent hybrid offspring from being formed. Drosophila melanogaster and D. simulans are two closely related species that can form sterile hybrids. In addition to their post-zygotic barriers, which cause the hybrid sterility, some behavioral pre-zygotic barriers also exist. These include different preferences for cour

Rare divergent RNAs in disease In human cells, genes are transcribed into an RNA before being translated into a protein, but first its structure under strict regulation undergoes changes called RNA splicing. Premature RNAs are organized in exon and intron units, where the latter are removed, to join exons together in the mature RNA. However, a variation of exon/intron combination can occur via a

Praematurum – mutanterna som snabbar på blomningen i korn Hordeum vulgare (känt som ”korn” i vardagligt språk) är idag världens fjärde mest odlade sädesslag och används framför allt som djurfoder och till ölbryggning. På grund av den globalt ökande populationen och ett nyligen återfunnet intresse i nationell självförsörjning så blir vikten av forskning inom växtförädling bara större och större. EWhen cultivating barley (Hordeum vulgare), access to cultivars with shorter flowering time can be helpful in various agricultural settings, such as the effort of expanding agricultural capabilities into colder regions with shorter growing seasons. The recently identified gene Praematurum-b (Mat-b) is known to cause the plants to flower 7 days early on average. This thesis aimed to analyze the effe

Evolutionen som livboj för en krympande slända Många organismer påverkas negativt av mänsklig miljöpåverkan, och riskerar att dö ut. Evolutionära processer kan dock fungera som en livboj och bromsa den negativa utvecklingen från miljöförändringar. Global uppvärmning driver en insektsart till en mindre kroppsstorlek. Men när naturlig selektion istället verkar för en stor kroppsstorlek kommer de neDue to human-induced environmental changes, many natural populations are undergoing extensive fitness declines. Natural or sexual selection could potentially shift the phenotypic mean of critical traits towards new phenotypic optima, promoting evolutionary rescue. However, this process has rarely been studied in natural populations. Furthermore, the population fitness can also be increased by gene

Spinosad: en pollinatörs mardröm Bekämpningsmedel är vanliga i jordbruket för att säkra skördar, men kan ha negativa effekter på nyttiga insekter. Spinosad, ett biologiskt bekämpningsmedel framställt ur bakterier och godkänt inom ekologiskt jordbruk i EU, angriper insekters nervsystem och orsakar muskelsammandragningar, förlamning och död. Mitt experiment visar att spinosad i fältrealistiska koncThe extensive use of pesticides within the agricultural landscape is essential for maintaining sufficient yields and sustaining our growing population, however, their widespread use is not without costs. Increasing evidence shows that pesticides harm many non-target organisms, including those providing vital ecosystem services. Pollinators, for instance, are critical for the fruiting of nearly 75%

Background: A Swedish version of the Patient-Rated Ulnar Nerve Evaluation (PRUNE-S), a patient-reported outcome measure for ulnar nerve entrapment, was created, according to cross-cultural adaptation guidelines, and reliability, validity, and responsiveness were evaluated. Methods: In total, 43 patients (mean [SD] age, 49 [16] y; 54% men) were consecutively examined, including the PRUNE-S (retest: