The ERBB2 gene encodes a receptor tyrosine kinase also known as HER2. The gene is amplified and overexpressed in one-fifth of breast carcinomas; patients with such tumors benefit from targeted treatment with trastuzumab or other drugs blocking the receptor. In addition, ERBB2 has been shown to be amplified and/or overexpressed in a variety of other malignancies. Notably, both alveolar and embryona

In the green bond market, bond issuers can obtain various types of external reviews to validate their green claims. This paper examines the impact of external reviews in the form of verification, second party opinion (SPO), and green bond rating on the yield spread between a green bond and a paired conventional bond in the secondary green bond market. We perform coarsened exact matching, followed

Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. DNA methylation profiling has emerged as a useful tool for robust tumor classification, providing new insights into these hetero

This article seeks to provide a new analytical framework based on factor endowments to understand growth in rural economies without structural transformation. More concretely, it explores the variation in farmers’ ability to respond to new commercial opportunities. To complement the extensive literature on the economic and institutional effects of factor endowments, this paper revisits two influen

Background and purpose: Inter-modality image registration between computed tomography (CT) and magnetic resonance (MR) images is associated with systematic uncertainties and the magnitude of these uncertainties is not well documented. The purpose of this study was to investigate the potential uncertainty of gold fiducial marker (GFM) registration for localized prostate cancer and to estimate the i

The progression of keratoconus is commonly determined by comparing the results of corneal tomographic measurements on different occasions. However, investigations on the repeatability of measurements are commonly performed within the same day, thus not taking the inter-day variation into account. The effect of keratoconus disease severity on the measurement error is also seldom considered. In this

This paper demonstrates how a strain energy transition approach can be used to remove artificial buckling modes that often occur in stability constrained topology optimization problems. To simulate the structural response, a nonlinear large deformation hyperelastic simulation is performed, wherein the fundamental load path is traversed using Newton’s method and the critical buckling load levels ar

Austrian artist and director of ZKM Center for Art and Media in Karlsruhe, Germany, Peter Weibel (Odessa, 1944), curates a book/catalogue of the mythical exhibition Sound Art, Sound as Medium of Art, that took place between March 2012 and February 2013 in Karlsruhe, with nearly one thousand images of sound art pieces. Along with a very detailed historical trace of sound as a form of art, the book

Background We aimed to document international practices in small-bowel capsule endoscopy (SBCE), measuring adherence to European Society of Gastrointestinal Endoscopy (ESGE) technical and clinical recommendations. Methods Participants reached through the ESGE contact list completed a 52-item web-based survey. Results 217 responded from 47 countries (176 and 41, respectively, from countries

Svenskt bokindustrimuseum initierades av Waldemar Zachrisson vid sekelskiftet 1900 och var kopplat till Svenska Boktryckareföreningen. Artikeln är den andra i en serie som behandlar museets historia.

The Jurassic sandstones around Höör and Vittseröd in central Skåne, southern-most Sweden are almost unique for Sweden and have been subjected to quarrying for at least 1000 years to produce millstones and building blocks for major buildings including the Lund cathedral. In the present study, the bryophyte flora of 17 such old or ancient sandstone quarries is investigated and described. A total of

Svenskt bokindustrimuseum initierades av Waldemar Zachrisson vid sekelskiftet 1900 och var kopplat till Svenska Boktryckareföreningen. Artikeln är den tredje i en serie som behandlar museets historia. Artikeln täcker tiden cirka 1920–1990 och behandlar bl a skapandet av boktryckerimuseet Officina Typographica på Skansen.

Background: In egg-laying animals, mothers can influence the developmental environment and thus the phenotype of their offspring by secreting various substances into the egg yolk. In birds, recent studies have demonstrated that different yolk substances can interactively affect offspring phenotype, but the implications of such effects for offspring fitness and phenotype in natural populations have

This chapters shed light on mobile socialities via a focus on bicycling food couriers, a group of workers who holds a peripheral position in the power geometry of mobility. The absence of proper workplace justifies a particular focus on the mobile phone. Hence, the chapter is a theoretical enquiry in order to elaborate the all-encompassing role of the mobile phone for this kind of work; how it is

Avhandlingen består av fyra artiklar som alla kretsar kring hur ett effektivt nyttjande av infrastruktur kan uppnås. Tre av artiklarna berör externaliteter i transportsektorn medan den fjärde artikeln rör bostadsmarknaden och hur en skattereform påverkade äldre småhusägares flyttbeteende. Externaliteter uppstår när de beslut som en person (eller företag) tar har effekter även för andra och detta iAll four papers in the thesis share a common theme: how to achieve an efficient use of infrastructure and the built environment. In the presence of externalities, pricing according to the (short-run) marginal cost is one answer on how this can be achieved and the first two papers estimates parts of the marginal cost of traffic. Paper I examines the effect of road and railway noise on property pric