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B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis. DUX4 fusions have been challenging to identify. We aimed to determine wheth

Introduction: Depression and anxiety disorders affect individuals' everyday lives, and treatments that can help them to perform everyday occupations are needed. Occupational therapy for this group has been evaluated from a short-term perspective but not from a long-term perspective; further research is thus warranted. The aim of the study was to investigate the longitudinal outcomes of the Tree Th

Objective: The indication of surgery in primary hyperparathyroidism has been controversial, as many patients experience mild disease. The primary aim was to evaluate fracture incidence in a contemporary population-based cohort of patients having surgery for primary hyperparathyroidism. The secondary aim was to investigate whether preoperative serum calcium, adenoma weight or multiglandular disease

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) are high-risk factors of diabetes development and may be caused by defective insulin secretion in pancreatic beta-cells. Glucose-stimulated insulin secretion is mediated by voltage-gated Ca2+ (CaV) channels in which the gamma-4 subunit (CaVγ4) is required for the beta-cell to maintain its differentiated state. We here aim to explo

The Covid-19 pandemic pushed consumers' reliance on digital services to a whole new level. Today consumers accomplish most of their daily tasks - shopping, working,maintaining personal relationships - over the Internet. It goeswithout saying, such online interactions require collection ofa large amount of data, which might put consumers at unease.In this survey, our objective is to uncover what "d

Background: the ageing global population is living longer with complex health conditions addressed by multiple medications. Little is known about how older people manage these medications and associated packaging at home. Objectives: to explore how older people manage the use of multiple medication and associated packaging in their process of self-care. Methods: fifteen older, home-dwelling partic

Very few countries have managed to decouple economic growth from greenhouse gas emissions in absolute terms and where this was achieved at rates too slow to meet the climate targets of the Paris agreement. To do so, technological solutions would need to be combined with sufficiency-oriented policies in a post growth context. Contributing to such a policy strategy, this paper explores the potential

BACKGROUND: Self-management programs are recognized as a valuable approach to supporting people with long-term conditions, such as stroke, in managing their daily lives. Bridges Self-Management (Bridges) focuses on how practitioners interact and support patients' confidence, skills, and knowledge, and it is an example of a complex intervention. Bridges has been developed and used across multiple h

There is a clear and urgent need to accelerate the implementation of sustainability solutions. We must move beyond simple conceptual understanding of solutions, instead experimenting with collaborators in contexts in order to improve effectiveness, share learnings with others, and avoid future mistakes that waste time.In this episode, we discuss nature-based solutions as a holistic approach addres

BackgroundThere is a need for a measure that can be used across countries and cultures to advance cross-cultural research about internalizing mental health symptoms in children and adolescents. The Revised Children's Anxiety and Depression Scale (RCADS) is a potential candidate, but no study has examined whether its scales are measured similarly in youth populations from different countries.Method

In the past decade, driven by the demand for materials with high performance for next-generation semiconductor devices (e.g., for quantum computing), the exploration of III-V semiconductor materials and the design of improved devices based on these materials has extended to the nanometer scale, with several highlights in the studies of quantum wells, quantum dots, and nanowires (NW) in recent year

I proposition 2021/22:153 Genomförandet av elmarknadsdirektivet fastslår regeringen att det i nuläget inte krävs någon ny lagstiftning för att reglera energigemenskaper. Energimarknadsinspektionen, som hade ansvaret att utreda frågan, föreslog att energigemenskaper skulle vara ekonomiska föreningar med ett skyddat namn där det framgår att de är just energigemenskaper. I propositionen bedömer reger

The book identifies the key analytical issues that need to be considered in determining whether a State is responsible under the ECHR for omissions. The focal question is whether and how omissions by the State can be conceptualised into failures to fulfil positive obligations. In addition to this technical analytical question, the book also reflects upon what is at stake for the political communit

Interactions between colloidal particles can be modelled by particles grafted with polymers. In this work, structural and physical properties of colloids are investigated under variation of parameters such as pH, ionic strength, and temperature, where aggregation and cluster formation can be monitored in aqueous solution. Being the subject of our work, in particular, we show that linear or polymer

The normally functioning heart delivers a steady supply of oxygen and nutrients to the body over a broad range of physiological states and loading conditions. Efficient cardiac performance at rest and during exercise is therefore a primary evolutionary directive for survival. The four-chambered heart is primarily a volume pump. It couples systolic and diastolic properties because of simultaneous r

Proton-emission branches of the 10+ isomer in the Tz=−1 nucleus 54Ni have been imaged with the active target and time projection chamber (ACTAR TPC) in an experiment conducted at the Grand Accélérateur National d'Ions Lourds (GANIL). The completed decay scheme allows derivation of the reduced transition strengths, B(E2;10+→8+) and B(E4;10+→6+), for the two competing γ-ray transitions. By means of

This book presents an invaluable collection of essays by eminent scholars from a wide variety of disciplines on the main issues currently confronting legal professions across the world.It does this through comparative analyses of the data provided by the reports on 46 countries in its companion volume: Lawyers in 21st-Century Societies: Vol. 1: National Reports, published in 2020. Together these v