Degradation of extracellular matrix, is a prerequisite for processes like tumor invasion and angiogenesis. Numerous studies indicate that plasminogen activation, initiated by u-PA, is a key process in malignant tumor growth. The expression of u-PA as well as its receptor is increased in malignant ovarian tumors. Additionally, u-PA stimulates signal transduction leading to cell proliferation and mi

15 filmade samtal mellan lärarstuderande, handledare och besökande vfu-lärare

Oxidative stress is defined as an imbalance between oxidants and antioxidants. The reasons behind the condition are diverse, and can result in, or contribute to, the severity of many diseases. The body has different protective mechanisms to reduce the oxidative burden, among them a protein called α1-microglobulin (A1M). A1M possesses a unique set of molecular properties enabling it to act as aradi

Multiple missiles were fired at Erbil on February 15, killing at least one civil contractor and injuring at least one American national. It is likely that the attack was conducted by an Iranian proxy in order to put pressure on President Biden to lift the sanctions against the country and return to the 2015 nuclear deal.

A number of virtual reality head-mounted displays (HMDs) with integrated eye trackers have recently become commercially available. If their eye tracking latency is low and reliable enough for gaze-contingent rendering, this may open up many interesting opportunities for researchers. We measured eye tracking latencies for the Fove-0, the Varjo VR-1, and the High Tech Computer Corporation (HTC) Vive

Transfusion-related acute lung injury (TRALI) is a hazardous transfusion complication with an associated mortality of 5% to 15%. We previously showed that stored (5 days) but not fresh platelets (1 day) cause TRALI via ceramide-mediated endothelial barrier dysfunction. As biological ceramides are hydrophobic, extracellular vesicles (EVs) may be required to shuttle these sphingolipids from platelet

Research on sustainability transitions has expanded rapidly in the last ten years, diversified in terms of topics and geographical applications, and deepened with respect to theories and methods. This article provides an extensive review and an updated research agenda for the field, classified into nine main themes: understanding transitions; power, agency and politics; governing transitions; civi

Treatment of depression is hampered by the failure to identify distinct symptom profiles with distinct pathophysiologies that differentially respond to distinct treatments. We posit that inflammatory depression is a meaningful depression subtype associated with specific symptoms and biological abnormalities. We review several upstream, potentially causative, mechanisms driving low-grade inflammati

Background and objective To study the cumulative incidence and surgical treatment of midline incisional hernia (MIH) after cystectomy for bladder cancer. Methods In the nationwide Bladder Cancer Data Base Sweden (BladderBaSe), cystectomy was performed in 5646 individuals. Cumulative incidence MIH and surgery for MIH were investigated in relation to age, gender, comorbidity, previous laparotomy and

This chapter introduces an institutional perspective on sustainability transitions. Sustainability transitions entail the destabilization and de-institutionalization of existing socio-technical regimes in various industries and the creation and diffusion, hence institutionalization, of new, potentially more sustainable socio-technical configurations. Institutional theory thus provides excellent in

We witness rising tensions between online gig-economy platforms, incumbent firms, regulators, and labor unions. In this chapter, we use the framework of institutional logics as an analytical lens and scheme to understand the fundamental institutional challenges prompted by the advent of the online gig economy. We view gig-economy platforms as corporations that organize and self-regulate markets. I

Rather than viewing online platforms as digital marketplaces, we analyze platforms as corporations and platform participants as a workforce. Online platforms perform very similar functions as any other corporation, but in different ways (applying terms and conditions as a legal framework and data, reviews, and algorithms for decentralized control) and mostly in different contexts (informal labor m

The main goal of this article is to evaluate the relationship between the spatial distribution of the population of the city of Belo Horizonte, one of the largest cities in South America, and its public transport network, seeking to ascertain whether the current bus network is able to meet the needs of the population. The methodology was based on data processing and vector information from differe

The inclusive production of the J/ψ and ψ(2S) charmonium states is studied as a function of centrality in p-Pb collisions at a centre-of-mass energy per nucleon pair sNN = 8.16 TeV at the LHC. The measurement is performed in the dimuon decay channel with the ALICE apparatus in the centre-of-mass rapidity intervals −4.46 < ycms< −2.96 (Pb-going direction) and 2.03 < ycms< 3.53 (p-going direction),