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Surrendering to Anesthesia - An Interpersonal Construct in the Caring Encounter within the Context of Anesthesia Care
Developing a framework for studying brain networks in neonatal hypoxic-ischemic encephalopathy
Newborns with hypoxic-ischemic encephalopathy (HIE) are at high risk of brain injury, with subsequent developmental problems including severe neuromotor, cognitive and behavioral impairment. Neural correlates of cognitive and behavioral impairment in neonatal HIE, in particular in infants who survive without severe neuromotor impairment, are poorly understood. It is reasonable to hypothesize that
Den ofärdiga vetenskapen : Om krisen i svensk litteraturforskning och litteraturtolkningens villkor
Denna avhandling undersöker en brist på konsensus inom den svenska litteraturvetenskapliga forskningen gällande såväl dess objekts grundläggande egenskaper, som vilka teorier och metoder för att studera detta objekt som är mest giltiga. Från perspektivet av denna brist, föreställd som en epistemologisk ”kris”, utforskas här möjligheterna för att betrakta detta sakförhållande som produktivt av kuns
Selected biomarkers correlate with the origin and severity of sepsis
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1β), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56
It's time to talk about mobility disability and overweight : Quality of life and need of preventive measures from the perspective of people with mobility disability and public health nurses
AbstractOverweight and obesity are more common among adult people with mobility disability (MD). Epidemiological studies are sparse in Sweden when it comes to the prevalence of MD and weight, differences between people with MD compared to those without MD, as well as the association to HRQoL. In addition, general guidelines in obesity prevention and treatment adapted to people with MD are lacking
The Sirius Passet Lagerstätte of North Greenland—A geochemical window on early Cambrian low-oxygen environments and ecosystems
The early Cambrian Sirius Passet fauna of northernmost Greenland (Cambrian Series 2, Stage 3) contains exceptionally preserved soft tissues that provide an important window to early animal evolution, while the surrounding sediment holds critical data on the palaeodepositional water-column chemistry. The present study combines palaeontological data with a multiproxy geochemical approach based on sa
Global pentapeptide statistics are far away from expected distributions
The relationships between polypeptide composition, sequence, structure and function have been puzzling biologists ever since first protein sequences were determined. Here, we study the statistics of occurrence of all possible pentapeptide sequences in known proteins. To compensate for the non-uniform distribution of individual amino acid residues in protein sequences, we investigate separately all
From climates multiple to climate singular : Maintaining policy-relevance in the IPCC synthesis report
The Intergovernmental Panel on Climate Change (IPCC) has provided periodic assessments of the state of knowledge on climate change for 30 years. While these assessments have been central to the making of international climate policy, their relevance has been questioned in the post-Paris era. Can the IPCC's global kinds of knowledge match the demands of an increasingly decentralized and polycentric
RIFM fragrance ingredient safety assessment, acetal, CAS Registry Number 105-57-7
Petition to replace current OGTT criteria for diagnosing prediabetes with the 1-hour post-load plasma glucose ≥ 155 mg/dl (8.6 mmol/L)
Many individuals with prediabetes, as presently defined, will progress to diabetes (T2D) despite the considerable benefit of lifestyle modification. Therefore, it is paramount to screen individuals at increased risk with a more sensitive method capable of identifying prediabetes at an even earlier time point in the lengthy trajectory to T2D. This petition reviews findings demonstrating that the 1-
RIFM fragrance ingredient safety assessment, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-5-yl pivalate, CAS Registry Number 68039-45-2
Glucose homeostasis dependency on acini–islet–acinar (AIA) axis communication : a new possible pathophysiological hypothesis regarding diabetes mellitus
Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion
Computational Methods in Conceptual Structural Design
Conceptual design is the first phase in the design process in which all the requirements and design objectives are synthesized into conceptual alternatives. In practice today, major decisions regarding the buildings function, massing, and overall form are usually made during the first phase. Considering structural performance requirements during conceptual design enhances interdisciplinary interac
RIFM fragrance ingredient safety assessment, benzyl methyl ether, CAS Registry Number 538-86-3
Generating initial reinforcement layouts using graphic statics
A key step to the strut-and-tie method is the selection of an appropriate truss model, due to the static indeterminacy of reinforced concrete there are often several suitable models possible. A method for automatically generating a suitable truss model by using graphic statics is presented. Optimal layouts are found by minimizing the total load path. A formulation of constraints suitable for gener
Unravelling protein stability and aggregation
Proteiner är fascinerande makromolekyler som är fundamentala för alla levandeorganismer. De utgör byggstenar i våra celler, ansvarar för transport och signalering både inom och mellan våra celler, utgör en del av vårt immunförsvar och katalyserar bildningen av andra molekyler. Proteiner består av flexibla kedjor uppbyggda av olika aminosyror. Varje aminosyra har olika egenskaper och den specifika Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. At high concentrations proteins are susceptible to self-association, which may lead to amyloid fibril formation – a process linked to many diseases, such as Alzheimer’s disease, Park
RIFM fragrance ingredient safety assessment, β-caryophyllene alcohol, CAS Registry Number 472-97-9
RIFM fragrance ingredient safety assessment, 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-inden-5-yl isobutyrate, CAS registry number 67634-20-2
Cost-effectiveness of optimized adherence to prevention guidelines in European patients with coronary heart disease : Results from the EUROASPIRE IV survey
Background: This study aims to assess the cost-effectiveness of optimized guideline adherence in patients with a history of coronary heart disease. Methods: An individual-based decision tree model was developed using the SMART risk score tool which estimates the 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease (CVD). Analyses were based on the EUROASPIRE
